This Week in Neuroscience

Helen joins TWiN to discuss her work on understanding how the maternal microbiome modulates fetal neurodevelopment in mice.

Hosts: Ori Lieberman, Andres Bendesky, Jason Shepherd, and Vincent Racaniello

Guest: Helen Vuong

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Links for this episode

• Maternal microbiome influences fetal neurodevelopment (Nature)
• Timestamps by Jolene. Thanks!

Music is by Ronald Jenkees

Send your neuroscience questions and comments to [email protected]

Ori, Jason, and Vincent discuss the use of antibodies to neutralize amyloid-β seeds before their deposition becomes detectable in transgenic mice, and the finding that the preclinical phase of Alzheimer's disease may be a late manifestation of earlier pathogenic seed formation.

Hosts: Ori Lieberman, Jason Shepherd, and Vincent Racaniello

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Links for this episode

• Reducing Alzheimer-like pathology in mice (Nat Neurosci)
• Letters read on TWiN 13
• Timestamps by Jolene. Thanks!

Music is by Ronald Jenkees

Send your neuroscience questions and comments to [email protected]

Ori, Jason, Erin, and Vincent dissect a study that utilizes single-cell RNA sequencing to reveal the genes that underlie remote memory storage in the medial prefrontal cortex of the mouse.

Hosts: Ori Lieberman, Erin Calipari, Jason Shepherd, and Vincent Racaniello

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Links for this episode

• Transcriptional programs associated with long-term memory (Nature)
• Timestamps by Jolene. Thanks!

Music is by Ronald Jenkees

Send your neuroscience questions and comments to [email protected]

Ori, Jason, and Vincent reveal identification of an orphan receptor that modifies short-term memory in mice, and a mouse model of COVID-19 that includes anosmia or loss of smell.

Hosts: Ori Lieberman, Vincent Racaniello, and Jason Shepherd Subscribe (free): iTunes, Google Podcasts, RSS, email

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Links for this episode

• Thalamic orphan receptor in short term memory (Cell)
• Anosmia in SARS-CoV-2 infected mice (Nature)
• Letters read on TWiN 12
• Timestamps by Jolene. Thanks!

Music is by Ronald Jenkees

Send your neuroscience questions and comments to [email protected]

Maria joins TWiN to explain how single-cell transcriptomics is being used to reveal the evolution of the brain, at a cost of about $1 per neuron.

Hosts: Ori Lieberman, Andres Bendesky, and Vincent Racaniello

Guest: Maria Tosches

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Links for this episode

• Single-cell transcriptomics of reptile cortex (Science)
• Innovations in primate interneurons (Nature)
• Human versus mouse cortex (Nature)
• Letters read on TWiN 11
• Timestamps by Jolene. Thanks!

Music is by Ronald Jenkees

Send your neuroscience questions and comments to [email protected]

TWiN explains how a cytokine produced by neurons activates microglia which modify the extracellular matrix and remodel synapses, leading to memory consolidation.

Hosts: Ori Lieberman, Andres Bendesky, Erin Calipari, Jason Shepherd and Vincent Racaniello

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Links for this episode

• IL-33 promotes synaptic plasticity (Cell)
• Timestamps by Jolene. Thanks!

Music is by Ronald Jenkees

Send your neuroscience questions and comments to [email protected]

Columbia University Chief Neurology Resident Genna Waldman joins TWiN to explains how her department prepared for COVID-19, and the neurological symptoms associated with the disease.

Hosts: Ori Lieberman, Andres Bendesky, Jason Shepherd and Vincent Racaniello

Guest: Genna Waldman

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Links for this episode

• Preparing a neurology department for COVID-19 (Neurology)
• Managing comatose COVID-19 patients (Ann Neurol)
• Neuropathology of COVID-19 (NEJM)
• Letters read on TWiN 9
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your neuroscience questions and comments to [email protected]

TWiN explains how neurological disease in mice can be repaired by using CRISPR/Cas to knock down levels of a single cell protein, which converts astrocytes to neurons.

Hosts: Ori Lieberman, Erin Calipari, Jason Shepherd and Vincent Racaniello

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Links for this episode

• Converting glia to neurons (Cell)
• Reversing Parkinson's disease (Nature)
• Letters read on TWiN 8
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your neuroscience questions and comments to [email protected]

The TWiN team reveals how the nervous system controls hair graying in mice subjected to stress, and adaptive immune responses.

Hosts: Ori Lieberman, Jason Shepherd, Erin Calipari and Vincent Racaniello

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Links for the episode

• The hair cycle (J Cell Sci)
• Hyperactivation of sympathetic nerves drives hair greying (Nature)
• Brain control of humoral immune responses (Nature)
• Letters read on TWiN 7
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your neuroscience questions and comments to [email protected]

Nirao Shah joins TWiN to discuss the work of his laboratory on how our brains generate social interactions that differ between the sexes.

Hosts: Ori Lieberman, Andres Bendesky, andJason Shepherd

Guest: Nirao Shah

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Links for this episode

• Nirao Shah laboratory
• Neural circuit remodeling and sexual behavior (Cell)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your neuroscience questions and comments to [email protected]