TWiN explains how anti-DNA antibodies present in lupus patients bind to GluN2A-containing NMDA receptors, act as positive allosteric modulators, and impair spatial memory.

Hosts: Vincent Racaniello, Ori Lieberman, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

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• Lupus autoantibodies bind GluN2A-containing NMDA receptors (Nat Commun)
• Timestamps by Jolene. Thanks!

Music is by Ronald Jenkees

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TWiN explores a study of hallucination-like perception in mice which supports the idea that hallucinations arise as faulty perceptual inferences due to elevated dopamine in the striatum.

Hosts: Vincent Racaniello, Ori Lieberman, and Timothy Cheung

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• Listener poll - please take it
• Striatal dopamine and hallucination in mice (Science)
• Timestamps by Jolene. Thanks!

Music is by Ronald Jenkees

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While perceptual constancy requires the brain to maintain a stable representation of sensory input, TWiN explores a study showing that odor-evoked responses in the olfactory cortex drift over periods of days to weeks.

Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

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• Representational drift in olfactory cortex (Nature) (open preprint)
• Ed Yong on representational drift (Atlantic)
• Letters read on TWiN 20
• Timestamps by Jolene. Thanks!

Music is by Ronald Jenkees

Send your neuroscience questions and comments to [email protected]

On this episode, Vivianne gives a primer on glial cells, with the goal of thinking about the central nervous system holistically and appreciating the different cell types that contribute to its function.

Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

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Music is by Ronald Jenkees

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Mauro Costa-Mattioli joins TWiN to discuss how his laboratory dissects the contribution of host genetics and the microbiome in complex neurodevelopment disorders such as autism spectrum disorders.

Hosts: Vincent Racaniello, Ori Lieberman, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

Guest: Mauro Costa-Mattioli

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• Mauro’s work on TWiM 131 and 193
• Separating genetics and microbiome in autism (Cell)
• Please take our listener poll
• Timestamps by Jolene. Thanks!

Music is by Ronald Jenkees

Send your neuroscience questions and comments to [email protected]

Michael Nitabach joins TWiN to discuss the finding that the nematode C. elegans, which do not have eyes, can discriminate between colors to guide foraging decisions and move them away from harmful bacteria that produce a blue-pigment toxin.

Hosts: Vincent Racaniello, Ori Lieberman, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

Guest: Michael Nitabach

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• C. elegans discriminates colors (Science)
• Timestamps by Jolene. Thanks!

Music is by Ronald Jenkees

Send your neuroscience questions and comments to [email protected]

Stefano joins TWiN to discuss his work on understanding genomic decoding of neuronal depolarization by stimulus-specific transcriptional regulators.

Hosts: Ori Lieberman, Jason Shepherd, and Timothy Cheung

Guest: Stefano Brigidi

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• Genomic decoding of neuronal depolarization (Cell)
• Timestamps by Jolene. Thanks!

Music is by Ronald Jenkees

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Helen joins TWiN to discuss her work on understanding how the maternal microbiome modulates fetal neurodevelopment in mice.

Hosts: Ori Lieberman, Andres Bendesky, Jason Shepherd, and Vincent Racaniello

Guest: Helen Vuong

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• Maternal microbiome influences fetal neurodevelopment (Nature)
• Timestamps by Jolene. Thanks!

Music is by Ronald Jenkees

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Ori, Jason, and Vincent discuss the use of antibodies to neutralize amyloid-β seeds before their deposition becomes detectable in transgenic mice, and the finding that the preclinical phase of Alzheimer‘s disease may be a late manifestation of earlier pathogenic seed formation.

Hosts: Ori Lieberman, Jason Shepherd, and Vincent Racaniello

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• Reducing Alzheimer-like pathology in mice (Nat Neurosci)
• Letters read on TWiN 13
• Timestamps by Jolene. Thanks!

Music is by Ronald Jenkees

Send your neuroscience questions and comments to [email protected]

Ori, Jason, Erin, and Vincent dissect a study that utilizes single-cell RNA sequencing to reveal the genes that underlie remote memory storage in the medial prefrontal cortex of the mouse.

Hosts: Ori Lieberman, Erin Calipari, Jason Shepherd, and Vincent Racaniello

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• Transcriptional programs associated with long-term memory (Nature)
• Timestamps by Jolene. Thanks!

Music is by Ronald Jenkees

Send your neuroscience questions and comments to [email protected]