This Week in Startups

This Week in Startups

By Jason CalacanisTechnology
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This Week in Startups episodes

  • David Friedberg on AI-First Startups & the Future of Biology, Business & Creativity | AI Basics with Google Cloud

    In this episode, Jason chats with David Friedberg—CEO of Ohalo Genetics and co-host of the All-In Podcast—about how AI is transforming agriculture and startups. David introduces Ohalo's "Boosted Breeding" technology, which enables plants to inherit 100% of genes from both parents, potentially doubling crop yields. They also discuss building AI-first companies, genome language models, and the future of creativity in an AI-driven world.

    *

    Timestamps:

    (0:00) David Friedberg joins Jason to discuss AI Basics.

    (1:44) How AI leveled up hiring and operations at startups

    (5:46) AI and economic opportunities, complex problem-solving, and leadership's role

    (11:48) How to build an AI-first company culture

    (16:48) AI's transformative impact on biology and DNA sequencing

    (21:36) The "GLM" - GPT for DNA Is already in production

    (23:17) Biology meets AI: designing perfect plants with CRISPR and genome models

    (32:08) Is the "Age of Abundance" around the corner?

    (35:56) Democratization of creativity through AI: personalized Star Wars musicals & the future of media

    *

    Uncover more valuable insights from AI leaders in Google Cloud's 'Future of AI: Perspectives for Startups' report. Discover what 23 AI industry leaders think about the future of AI—and how it impacts your business. Read their perspectives here: https://goo.gle/futureofai

    *

    Check out all of the Startup Basics episodes here: https://thisweekinstartups.com/basics

    Check out Google Cloud: https://cloud.google.com/

    Check out Ohalo: https://www.ohalo.com/

    *

    Follow David:

    X: https://x.com/friedberg

    LinkedIn: https://www.linkedin.com/in/davidfriedberg/

    *

    Follow Jason:

    X: https://twitter.com/Jason

    LinkedIn: https://www.linkedin.com/in/jasoncalacanis

    *

    Follow TWiST:

    Twitter: https://twitter.com/TWiStartups

    YouTube: https://www.youtube.com/thisweekin

    Instagram: https://www.instagram.com/thisweekinstartups

    TikTok: https://www.tiktok.com/@thisweekinstartups

    Substack: https://twistartups.substack.com

    42 min
  • Jony Ive Joins OpenAI, Waymo Hits 10M Rides, and How to Launch a Marketplace from Scratch | E2129

    Today's show: Jason and Alex dicsuss Jony Ive's $6.5B deal with OpenAI and what it means for the future of AI hardware, Tesla's push into robotaxis vs. Waymo's 10M paid rides, and Microsoft's latest move partnering with xAI. We dive into the GENIUS Act and what it means for stablecoin regulation, explore practical, gritty tactics for launching and scaling a marketplace from scratch, and debate the ethics of AI-powered smart glasses and always-on recording. Plus, Jason reflects on the legacy of Scott Adams and the power of systems thinking.


    Timestamps:

    (0:00) Episode Teaser(2:00) A broadcaster-to-broadcaster moment for Scott Adams(5:18) OpenAI teams with Jony Ive, and why wearables are banned from the J-Ranch(10:16) Vanta - Get $1000 off your SOC 2 at https://www.vanta.com/twist(16:11) From Partnership to Purchase: The M&A Story(20:09) Squarespace - Use offer code TWIST to save 10% off your first purchase of a website or domain at https://www.Squarespace.com/TWIST(25:42) Robotaxis EVERYWHERE, and thoughts on the continuing self-driving car rollout(30:12) Brex. Get the business account trusted by 1 in 3 US startups at ⁠https://www.brex.com/banking-solutions(34:41) Should we trust stablecoins now? And who is actually monitoring this?(42:54) Polymarkets: Checking in with some of our favorite market(49:58) REDDIT QUESTION: How do I build a marketplace?(58:53) Customer feedback's role in product iteration(58:55) Every piece of SaaS advice EVER


    Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com

    Check out the TWIST500: https://www.twist500.com

    Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp


    Links from episode:

    Polymarket: https://polymarket.com/

    Polymarket for AI Leaderes: https://polymarket.com/event/which-company-has-best-ai-model-on-june-30

    LMArena: https://www.lmarena.ai

    Real Coffee with Scott Adams: https://www.youtube.com/RealCoffeeWithScottAdams

    Follow Lon:

    X: https://x.com/lons


    Follow Alex:

    X: https://x.com/alex

    LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm


    Follow Jason:

    X: https://twitter.com/Jason

    LinkedIn: https://www.linkedin.com/in/jasoncalacanis


    Thank you to our partners:

    (10:16) Vanta - Get $1000 off your SOC 2 at https://www.vanta.com/twist

    (20:09) Squarespace - Use offer code TWIST to save 10% off your first purchase of a website or domain at https://www.Squarespace.com/TWIST

    (30:12) Brex. Get the business account trusted by 1 in 3 US startups at ⁠https://www.brex.com/banking-solutions


    Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland


    Check out Jason's suite of newsletters: https://substack.com/@calacanis


    Follow TWiST:

    Twitter: https://twitter.com/TWiStartups

    YouTube: https://www.youtube.com/thisweekin

    Instagram: https://www.instagram.com/thisweekinstartups

    TikTok: https://www.tiktok.com/@thisweekinstartups

    Substack: https://twistartups.substack.com


    Subscribe to the Founder University Podcast: https://www.youtube.com/@founderuniversity1916

    1 hr 6 min
  • Drones, Design, and Digital Espionage | E2128

    Today's show: Jason and Lon explore the wild edges of tech innovation and regulation — from a student-built acoustic weapon that takes down drones (without harming humans) to the legal gray areas of drone defense over private property. They also unpack the escalating espionage drama between Rippling and Deel, and dive into FireCrawl's viral move to hire AI agents as employees. Plus, a deep look at how world-class design and systems thinking can set startups apart. Packed with insights, laughs, and cutting-edge ideas across defense tech, AI, and startup strategy.


    Timestamps:

    (0:00) Episode Teaser(1:39) Intro and Jason and Lon share their love of Andor(6:52) How to spot "World Class Design" and why it matters(10:27) NetSuite - Download the CFO's Guide to AI and Machine Learning for free at https://www.netsuite.com/twist(15:50) Athena, Hillstone, and creating the right system(20:00) Northwest Registered Agent - Form your entire business identity in just 10 clicks and 10 minutes. Get more privacy, more options, and more done—visit northwestregisteredagent.com/twist today!(23:21) So... corporate espionage is BAD? is what you're saying?(30:14) Gemini Canvas - It uses AI to help you write, code, and create in one interactive space. Try it at gemini.google.com/canvas.(32:11) Why Firecrawl is hiring AI agents for staff positions(38:28) Bluesky might not be falling after all?(44:39) How Prandtl Dynamics is shooting drones out of the sky


    Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com

    Check out the TWIST500: https://www.twist500.com

    Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp


    Links from episode:

    Prandtl: https://prandtldynamics.com/


    Follow Lon:

    X: https://x.com/lons


    Follow Alex:

    X: https://x.com/alex

    LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm


    Follow Jason:

    X: https://twitter.com/Jason

    LinkedIn: https://www.linkedin.com/in/jasoncalacanis


    Thank you to our partners:

    (10:27) NetSuite - Download the CFO's Guide to AI and Machine Learning for free at https://www.netsuite.com/twist

    (20:00) Northwest Registered Agent - Form your entire business identity in just 10 clicks and 10 minutes. Get more privacy, more options, and more done—visit northwestregisteredagent.com/twist today!

    (30:14) Gemini Canvas - It uses AI to help you write, code, and create in one interactive space. Try it at gemini.google.com/canvas.


    Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland


    Check out Jason's suite of newsletters: https://substack.com/@calacanis


    Follow TWiST:

    Twitter: https://twitter.com/TWiStartups

    YouTube: https://www.youtube.com/thisweekin

    Instagram: https://www.instagram.com/thisweekinstartups

    TikTok: https://www.tiktok.com/@thisweekinstartups

    Substack: https://twistartups.substack.com


    Subscribe to the Founder University Podcast: https://www.youtube.com/@founderuniversity1916

    1 hr 4 min
  • Microsoft Layoffs, Immigration Blunders, & Office Hours with Jeremy Redman of Airfive | E2127

    Today's show: Microsoft lays off 6,000 employees despite record profits, signaling a ruthless new phase in big tech. Jason, Lon, and Alex discuss what it means for the talent market, why tightening U.S. immigration could cripple startup innovation, and whether AI startup Windsurf is selling too early as OpenAI circles. Plus, Klarna's AI customer service backfires, IPO momentum returns, and Office Hours with airfive founder Jeremy Redman pitches a bold new prepaid SaaS model.


    Timestamps:

    (0:00) Episode Teaser(2:40) Why ex-Microsoft staffers are talking smack on Blind(10:08) Atlassian - Head to https://www.atlassian.com/startups/twist to see if you qualify for 50 free seats for 12 months.(15:58) Checking out ElevenLabs' wild new AI soundboard(20:28) Fidelity Private Shares℠ - Visit ⁠https://fidelityprivateshares.com⁠! Mention our podcast and receive 20% off your first-year paid subscription.(24:02) What is Bottom Up TAM and why it isn't dirty like it sounds(30:10) Google Gemini - It uses AI to help you write, code, and create in one interactive space. Try it at gemini.google.com/canvas.(33:52) Cohere missed revenue estimates but things aren't THAT bleak!(37:01) Why America NEEDS highly skilled immigrants(43:12) Working the "I Have a Secret" strategy with Jeremy from Airfive

    Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com

    Check out the TWIST500: https://www.twist500.com

    Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp


    Links from episode:

    EleveLabs Sound Board: https://elevenlabs.io/sound-effects/soundboardLikable: https://likeable.co/airfive: https://airfive.com/


    Follow Jeremy:X: https://x.com/thejeremyredmanLinkedIn: https://www.linkedin.com/in/thejeremyredman/

    Follow Lon:

    X: https://x.com/lons


    Follow Alex:

    X: https://x.com/alex

    LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm


    Follow Jason:

    X: https://twitter.com/Jason

    LinkedIn: https://www.linkedin.com/in/jasoncalacanis


    Thank you to our partners:

    (10:08) Atlassian - Head to https://www.atlassian.com/startups/twist to see if you qualify for 50 free seats for 12 months.

    (20:28) Fidelity Private Shares℠ - Visit ⁠https://fidelityprivateshares.com⁠! Mention our podcast and receive 20% off your first-year paid subscription.

    (30:10) Google Gemini - It uses AI to help you write, code, and create in one interactive space. Try it at gemini.google.com/canvas.


    Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland


    Check out Jason's suite of newsletters: https://substack.com/@calacanis


    Follow TWiST:

    Twitter: https://twitter.com/TWiStartups

    YouTube: https://www.youtube.com/thisweekin

    Instagram: https://www.instagram.com/thisweekinstartups

    TikTok: https://www.tiktok.com/@thisweekinstartups

    Substack: https://twistartups.substack.com


    Subscribe to the Founder University Podcast: https://www.youtube.com/@founderuniversity1916

    1 hr 5 min
  • Chime's IPO, Databricks' $1B Acquisition & Dave Rubin's Media Empire | E2126

    Today's show: Chime is finally going public with strong financials and a shot at matching its $25B 2021 valuation, signaling real momentum in the IPO market. Databricks just made a $1B bet on agentic AI by acquiring Neon, a Postgres-as-a-service startup riding the new database wave. Then, Dave Rubin joins to share how he built and sold Locals, his uncancellable creator platform, all while navigating the intense media landscape.


    Timestamps:

    (0:00) Episode Teaser(1:14) Jason and Alex open the show(1:42) Why Chime's IPO is such a promising sign(7:22) Chime's financials and valuation(10:12) Squarespace - Use offer code TWIST to save 10% off your first purchase of a website or domain at https://www.Squarespace.com/TWIST(12:17) So why did Databricks buy Neon?(13:22) Where is the AI Integration Desktop App?(17:29) Jason's plan to bring Americans back to the movies(20:10) Northwest Registered Agent. Form your entire business identity in just 10 clicks and 10 minutes. Get more privacy, more options, and more done—visit northwestregisteredagent.com/twist today!(21:58) Make movies All-you-can-eat!(26:26) Special Guest: Dave Rubin(30:39) Lemon.io - Get 15% off your first 4 weeks of developer time at https://Lemon.io/twist(31:41) Why Dave Rubin goes phone free for weeks at a time(45:24) Why Identity politics is killing business and sports(49:23) Can Locals reinvent subscription models?


    Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com

    Check out the TWIST500: https://www.twist500.com

    Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp


    Links from episode:

    Rubin Report on Locals: https://rubinreport.locals.com/


    Follow Dave:

    X: https://x.com/RubinReport

    YouTube: https://www.youtube.com/channel/UCJdKr0Bgd_5saZYqLCa9mng

    Follow Lon:

    X: https://x.com/lons


    Follow Alex:

    X: https://x.com/alex

    LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm


    Follow Jason:

    X: https://twitter.com/Jason

    LinkedIn: https://www.linkedin.com/in/jasoncalacanis


    Thank you to our partners:

    (10:12) Squarespace - Use offer code TWIST to save 10% off your first purchase of a website or domain at https://www.Squarespace.com/TWIST

    (20:10) Northwest Registered Agent. Form your entire business identity in just 10 clicks and 10 minutes. Get more privacy, more options, and more done—visit northwestregisteredagent.com/twist today!

    (30:39) Lemon.io - Get 15% off your first 4 weeks of developer time at https://Lemon.io/twist


    Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland


    Check out Jason's suite of newsletters: https://substack.com/@calacanis


    Follow TWiST:

    Twitter: https://twitter.com/TWiStartups

    YouTube: https://www.youtube.com/thisweekin

    Instagram: https://www.instagram.com/thisweekinstartups

    TikTok: https://www.tiktok.com/@thisweekinstartups

    Substack: https://twistartups.substack.com


    Subscribe to the Founder University Podcast: https://www.youtube.com/@founderuniversity1916

    1 hr 7 min
  • Agentic AI Meets Cybersecurity + Solar Robots in the Desert | E2125

    Today's show: Alex interviews founders from two frontier technologies reshaping our world. First, ZioSec is tackling the cybersecurity risks of AI agents with continuous adversarial testing before real attacks happen. Then, Terabase shows how mobile robotic factories are transforming solar energy deployment, assembling massive solar farms directly in the desert. With AI scaling across enterprises and clean energy demand surging, these startups are building critical infrastructure for our future.


    Timestamps:

    (0:00) Introduction to the episode(0:53) Show Kickoff with Alex(1:15) ZioSec is Putting Agentic AI in Charge of Cybersecurity(9:41) Pilot - Visit https://www.pilot.com/twist and get $1,200 off your first year.(11:07)How Complex is ZioZec's Testing?(19:48) Superpower - The best founders know: better health = better business. Visit http://superpower.com/twist to skip the waitlist.(21:01) ZioSec's Vision for the Future(26:55) Terabase Wants to Transform How Solar is Built(30:00) Hubspot for Startups - Visit hubspot.com/startups and join the founders who are turning growth challenges into opportunities.(31:30) Is Solar Our AI Power Problem Savior?


    Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com

    Check out the TWIST500: https://www.twist500.com

    Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp


    Links from episode:

    Check out ZioSec: https://ziosec.com/

    Check out Terabase: http://www.terabase.energy


    Follow Aaron:

    LinkedIn: https://www.linkedin.com/in/aaron-walls/

    X: https://x.com/aaron0walls


    Follow Andruis:

    LinkedIn: https://www.linkedin.com/in/auseckas/


    Follow Terabase:X: https://x.com/terabaseenergy?lang=en


    Follow Lon:

    X: https://x.com/lons


    Follow Alex:

    X: https://x.com/alex

    LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm


    Follow Jason:

    X: https://twitter.com/Jason

    LinkedIn: https://www.linkedin.com/in/jasoncalacanis


    Thank you to our partners:

    (9:41) Pilot - Visit https://www.pilot.com/twist and get $1,200 off your first year.

    (19:48) Superpower - The best founders know: better health = better business. Visit http://superpower.com/twist to skip the waitlist.

    (30:00) Hubspot for Startups - Visit hubspot.com/startups and join the founders who are turning growth challenges into opportunities.


    Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland


    Check out Jason's suite of newsletters: https://substack.com/@calacanis


    Follow TWiST:

    Twitter: https://twitter.com/TWiStartups

    YouTube: https://www.youtube.com/thisweekin

    Instagram: https://www.instagram.com/thisweekinstartups

    TikTok: https://www.tiktok.com/@thisweekinstartups

    Substack: https://twistartups.substack.com


    Subscribe to the Founder University Podcast: https://www.youtube.com/@founderuniversity1916

    52 min
  • Anti-Work Uprising, Copyright Wars & the StreamFog Solution | E2124

    Today's show: Jason, Lon & Alex are back with a spicy Monday episode of This Week in Startups. Jason goes off on unions vs capitalism, we dig into why fewer seed startups are making it to Series A, and look at OpenAI's quiet copyright land grab. Plus: YC says Google should be broken up (then kind of walks it back), Perplexity's wild $14B valuation, and Saudi Arabia wants its own national AI. We wrap with an Office Hours chat with Kevin Bondzio from Streamfog on the future of AR ads in livestreaming.

    *

    Timestamps:

    (2:38) Why Jason's obsessed with Reddit's anti-work community

    (10:30) Coda - Get started for free at https://coda.io/twist

    (12:21) Seed Stage Graduation rates

    (20:43) LinkedIn Jobs - Post your first job for free at https://www.linkedin.com/twist

    (26:11) What's going on with Tech M&A?

    (30:04) Northwest Registered Agent. Form your entire business identity in just 10 clicks and 10 minutes. Get more privacy, more options, and more done—visit https://www.northwestregisteredagent.com/twist

    (33:50) What's going on with the Copyright Office?

    (37:24) Licensing and competitive advantage in the AI era

    (48:28) AI and the future of subscription-based content(56:42) StreamFog wants to change the way creators advertise

    (1:14:13) Perplexity's mega-valuation gets even mega-er

    (1:19:13) How Saudi Arabia just became an AI startup

    (1:22:05) Y Combinator pokes it's nose in the Google antitrust case

    *

    Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com

    Check out the TWIST500: https://www.twist500.com

    Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp

    *

    Links from episode:

    Check out Streamfog: https://streamfog.com/

    Check out Peter Walkers post on "Graduating from Seed to Series A" https://x.com/PeterJ_Walker/status/1921288778192200087

    Learn about the HUMAIN here: https://www.spa.gov.sa/en/N2316474

    *

    Follow Kev:

    X: https://x.com/kevbondzio

    LinkedIn: https://www.linkedin.com/in/kevin-bondzio/

    *

    Follow Lon:

    X: https://x.com/lons

    *

    Follow Alex:

    X: https://x.com/alex

    LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm

    *

    Follow Jason:

    X: https://twitter.com/Jason

    LinkedIn: https://www.linkedin.com/in/jasoncalacanis

    *

    Thank you to our partners:

    (10:30) Coda - Get started for free at https://coda.io/twist

    (20:43) LinkedIn Jobs - Post your first job for free at https://www.linkedin.com/twist

    (30:04) Northwest Registered Agent. Form your entire business identity in just 10 clicks and 10 minutes. Get more privacy, more options, and more done—visit https://www.northwestregisteredagent.com/twist

    *

    Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland

    *

    Check out Jason's suite of newsletters: https://substack.com/@calacanis

    *

    Follow TWiST:

    Twitter: https://twitter.com/TWiStartups

    YouTube: https://www.youtube.com/thisweekin

    Instagram: https://www.instagram.com/thisweekinstartups

    TikTok: https://www.tiktok.com/@thisweekinstartups

    Substack: https://twistartups.substack.com

    *

    Subscribe to the Founder University Podcast: https://www.youtube.com/@founderuniversity1916

    1 hr 31 min
  • OpenAI Scoops Instacart's CEO, AI in the Courtroom & Off-Road Startups | E2123

    Today's show: Jason, Alex, and Lon break down OpenAI's latest power move: hiring Instacart CEO Fidji Simo to lead its consumer apps. They also dive into the ethical storm brewing around an AI-generated victim statement used in court — is this the future of legal testimony? Plus, they explore how late-stage funding rounds like a "Series G" don't automatically spell trouble anymore, and what The Checklist Manifesto can teach startup founders. Stick around for another Office Hours, where WhereToWheel gets a shot at the spotlight.

    *

    Timestamps:

    (0:00) We kick off the show!

    (2:28) Intro: It's all about having a system...

    (8:52) Wait, OpenAI STOLE Instacart's CEO?

    (10:00) Brex. Get the business account trusted by 1 in 3 US startups at ⁠https://www.brex.com/banking-solutions

    (18:03) Why Adam Curry is the Podfather

    (20:08) LinkedIn Jobs - Post your first job for free at https://www.linkedin.com/twist

    (22:53) Would you want to be represented in court by an AI Avatar?

    (30:44) Vanta - Get $1000 off your SOC 2 at https://www.vanta.com/twist

    (35:38) What the heck is "Minor M&A"?

    (48:10) When are we all getting humanoid robots?

    (53:30) Where2Wheel wants to help you off-road

    Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com

    Check out the TWIST500: https://www.twist500.com

    Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp

    *

    Links from episode:

    Check out Wheel2Wheel: https://dev.where2wheel.com/

    *

    Follow Where2Wheel:

    X: https://x.com/Where2Wheel

    Linkedin: https://www.linkedin.com/company/where2wheel-llc/

    *

    Follow Lon:

    X: https://x.com/lons

    *

    Follow Alex:

    X: https://x.com/alex

    LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm

    *

    Follow Jason:

    X: https://twitter.com/Jason

    LinkedIn: https://www.linkedin.com/in/jasoncalacanis

    *

    Thank you to our partners:

    (10:00) Brex. Get the business account trusted by 1 in 3 US startups at ⁠https://www.brex.com/banking-solutions

    (20:08) LinkedIn Jobs - Post your first job for free at https://www.linkedin.com/twist

    (30:44) Vanta - Get $1000 off your SOC 2 at https://www.vanta.com/twist

    *

    Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland

    *

    Check out Jason's suite of newsletters: https://substack.com/@calacanis

    *

    Follow TWiST:

    Twitter: https://twitter.com/TWiStartups

    YouTube: https://www.youtube.com/thisweekin

    Instagram: https://www.instagram.com/thisweekinstartups

    TikTok: https://www.tiktok.com/@thisweekinstartups

    Substack: https://twistartups.substack.com

    *

    Subscribe to the Founder University Podcast: https://www.youtube.com/@founderuniversity1916

    1 hr 14 min
  • Zoox Crash Fallout, COATUE's $1B Open Fund, and Office Hours with FusionAds | E2122

    Today's show: Jason, Lon & Alex discuss the day's hottest tech and startup news. Zoox's robotaxi crash and voluntary recall, COATUE's innovative open-ended venture fund that could democratize private tech investing, the NSO Group's massive $167M fine for spyware abuse, Uber's record-setting earnings and in-person work push, and a candid AI wake-up call from Fiverr's CEO urging employees to embrace automation or fall behind. From regulatory shakeups to funding innovation and the rise of AI productivity, this episode captures the chaos and opportunity of tech in 2025.


    Timestamps:

    (1:09) Show Intro

    (2:43) Will Coatue's new low buy-in fund replace or supplement traditional VC investments?

    (9:55) OpenPhone - Streamline and scale your customer communications with OpenPhone. Get 20% off your first 6 months at www.openphone.com/⁠twist

    (13:38) Zoox issues recall: why this might be the best case scenario for self-driving cars.

    (20:18) Squarespace - Use offer code TWIST to save 10% off your first purchase of a website or domain at https://www.Squarespace.com/TWIST

    (22:39) Meta wins settlement against NSO: do spyware companies even need to exist?

    (25:45) Uber bests expectations in Q1! Why their future is looking bright.

    (29:48) Notion - Try it for free today at https://notion.com/twist

    (33:10) How scared should we be of AI replacing us? Fiverr's CEO says VERY.

    (40:57) In Office Hours, Evan from FusionAds wants to know: how to make clients feel more confident in with AI-generated marketing?

    (50:03) The Founder Friday Tournament's Final Four is now... a FINAL FIVE?!


    Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com

    Check out the TWIST500: https://www.twist500.com

    Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp


    Links from episode:

    Do Things That Don't Scale: https://paulgraham.com/ds.html

    FusionAds: https://www.fusionos.ai/ai-generative-advertising


    Follow Evan:X: https://x.com/EG_Fusion

    LinkedIn: https://www.linkedin.com/in/evangraj/

    Follow Lon:

    X: https://x.com/lons


    Follow Alex:

    X: https://x.com/alex

    LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm


    Follow Jason:

    X: https://twitter.com/Jason

    LinkedIn: https://www.linkedin.com/in/jasoncalacanis


    Thank you to our partners:

    (9:55) OpenPhone - Streamline and scale your customer communications with OpenPhone. Get 20% off your first 6 months at www.openphone.co

    (20:18) Squarespace - Use offer code TWIST to save 10% off your first purchase of a website or domain at https://www.Squarespace.com/TWIST

    (29:48) Notion - Try it for free today at https://notion.com/twist


    Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland


    Check out Jason's suite of newsletters: https://substack.com/@calacanis


    Follow TWiST:

    Twitter: https://twitter.com/TWiStartups

    YouTube: https://www.youtube.com/thisweekin

    Instagram: https://www.instagram.com/thisweekinstartups

    TikTok: https://www.tiktok.com/@thisweekinstartups

    Substack: https://twistartups.substack.com


    Subscribe to the Founder University Podcast: https://www.youtube.com/@founderuniversity1916

    1 hr 7 min
  • Cursor's $9B Round, AI-Powered Toys & CloudNuro's SaaS Fix | E2121

    Today's show: Cursor's explosive growth, hitting $200M in ARR and a massive $9B valuation. They also explore the buzz around Magical Toys' new AI-powered dinosaur, where LLMs meet playtime. The conversation turns to "vibe coding" and how AI dev tools are changing the way product teams build. Plus, Jason shares stories from his Formula 1 poker table, Uber's latest autonomous vehicle partnerships get analyzed, and we bring you highlights from our Founder Fridays pitch showdown, featuring Kippy from Sydney and MomSub from Chicago. Stick around to hear how Cloud Neuro is tackling SaaS sprawl.

    *

    Timestamps:

    (0:00) Jason kicks off the show!

    (3:52) Rise in popularity of F1 and Netflix's impact

    (10:23) Uber stock, partnerships, and self-driving technology

    (10:47) Northwest Registered Agent. Form your entire business identity in just 10 clicks and 10 minutes. Get more privacy, more options, and more done—visit https://www.northwestregisteredagent.com/twist

    today!

    (13:50) Aurora Innovation's SPAC and Cursor's valuation discussion

    (19:07) Revenue quality concerns for startups

    (20:17) Lemon.io - Get 15% off your first 4 weeks of developer time at https://Lemon.io/twist

    (21:37) User engagement versus churn in startups

    (23:06) AnySphere's ARR and impact of faster development on tech

    (30:29) Fidelity Private Shares℠ - Visit ⁠https://www.fidelityprivateshares.com! Mention our podcast and receive 20% off your first-year paid subscription.

    (32:11) Anker's portable solar solutions and off-grid living innovations

    (37:41) Jason's investment insights on Warner Brothers and Disney

    (38:27) Skype's decline and the rise of Zoom and Microsoft Teams

    (42:04) Founder Friday bracket final matchup and pitches

    (51:08) Interview with Fateen Anam Raffid from Magical Toys

    (59:24) Dino AI toy demonstration and future plans

    (1:04:20) Interview on CloudNuro's SaaS spend management

    (1:10:01) SaaS compliance, vendor-customer relationships, and AI spend management

    (1:16:09) CloudNuro's data-driven foundation and AI governance

    (1:18:46) Company growth, competitive landscape, and Chicago's entrepreneurial ecosystem*

    Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com

    Check out the TWIST500: https://www.twist500.com

    Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp

    *

    Links from episode:

    Magical Toys: https://www.magicaltoys.com

    CloudNuro: https://www.cloudnuro.ai/

    *

    Follow Fateen:

    X: https://x.com/Fateen_Anam

    *

    Follow Shyam:

    LinkedIn: https://www.linkedin.com/in/shyam-kumar-7b18524/:*

    Follow Lon:

    X: https://x.com/lons

    *

    Follow Alex:

    X: https://x.com/alex

    LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm

    *

    Follow Jason:

    X: https://twitter.com/Jason

    LinkedIn: https://www.linkedin.com/in/jasoncalacanis

    *

    Thank you to our partners:

    (10:47) Northwest Registered Agent. Form your entire business identity in just 10 clicks and 10 minutes. Get more privacy, more options, and more done—visit https://www.northwestregisteredagent.com/twist

    today!

    (20:17) Lemon.io - Get 15% off your first 4 weeks of developer time at https://Lemon.io/twist

    (30:29) Fidelity Private Shares℠ - Visit ⁠https://www.fidelityprivateshares.com/ Mention our podcast and receive 20% off your first-year paid subscription.

    *

    Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland

    *

    Check out Jason's suite of newsletters: https://substack.com/@calacanis

    *

    Follow TWiST:

    Twitter: https://twitter.com/TWiStartups

    YouTube: https://www.youtube.com/thisweekin

    Instagram: https://www.instagram.com/thisweekinstartups

    TikTok: https://www.tiktok.com/@thisweekinstartups

    Substack: https://twistartups.substack.com

    *

    Subscribe to the Founder University Podcast: https://www.youtube.com/@founderuniversity1916

    1 hr 26 min

About This Week in Startups

From the publisher's feed

Jason Calacanis covers startups, tech, markets, media, and all the hottest topics in business and technology. He also interviews the world's greatest founders, operators, investors, and innovators.

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