In this episode of Tox Talk on Bovine Science, Dr. Brad White and Dr. Scott Fritz discuss a case where multiple two-month-old calves in a dry lot died with minimal clinical signs. Initial differentials included infectious disease, nutritional issues, and ryegrass staggers, but necropsy and testing were largely unrewarding. Ultimately, elevated tissue lead levels confirmed lead poisoning, even though no clear source was identified. The case highlights the importance of considering lead toxicity in young calves with neurologic signs, especially when they have access to areas outside their normal environment.