Dr. Daisy Robinton, co-founder and CEO of Oviva Therapeutics, discusses the company's innovative approach to improving women's healthspan by targeting the biology of ovarian aging. Motivated by her personal experiences and the realization that female physiology is underserved by research and medicine, Daisy outlines how menopause is a key inflection point in the acceleration of aging in women. She explains the central role of anti-Mullerian hormone (AMH) in regulating ovarian function and fertility. Oviva's lead program, a recombinant enhanced AMH protein, aims to improve IVF outcomes by synchronizing follicle growth. Excitingly, this approach could also preserve ovarian reserve to delay menopause onset, thereby extending female healthspan.

Key Topics Covered:

• Pivoting from developmental biology to found a women's health startup
• Ovaries as central regulators of female healthspan beyond reproduction
• AMH as a brake on follicle activation and loss of ovarian reserve
• Using enhanced AMH to improve egg yield in poor-responding IVF patients
• Potential of AMH-based therapy to delay menopause and slow aging
• Menopause as the single greatest known accelerator of aging
• Economic and societal impact of extending female healthspan
• Distinguishing reproductive longevity from overall women's health
• Viewing fertility as a marker of overall health and wellbeing

Dr. Noah Davidsohn, co-founder and CSO of Rejuvenate Bio, discusses the company's innovative work using gene therapies to treat age-related diseases in dogs and humans. In his conversation with host Chris Patil, he explains his recent groundbreaking study showing that partial cellular reprogramming with Yamanaka factors extended lifespan and healthspan in very old mice. Noah then outlines Rejuvenate's clinical pipeline, including targeting longevity pathways like FGF-21 for heart disease and combining TGF-beta inhibition with klotho for osteoarthritis. By choosing secreted factors deliverable with liver-targeted gene therapy, Rejuvenate hopes to circumvent delivery challenges. Noah conveys an inspiring vision of adding healthy years to dogs' and humans' lives.

Key Topics Covered:

• Rejuvenate Bio's mission to reverse aging and age-related disease
• Lifespan doubling in old mice with cyclic Yamanaka factor induction
• Controllable gene therapy system for in vivo partial reprogramming
• Choice of FGF-21 for pleiotropic effects deliverable from liver
• Lead programs for arrhythmogenic cardiomyopathy and mitral valve disease
• Advantages of treating age-related diseases first in dogs
• Combination gene therapy for osteoarthritis: TGF-beta and klotho
• Secreted proteins enable broad effects without broad delivery
• Vision of expanding healthspan by "squaring the curve"
• Potential to keep people healthy, active and productive to 100+

30 Years of Aging Biology: A Pioneer’s Perspective (Cynthia Kenyon - VP Aging Biology, Calico Labs)

Dr. Cynthia Kenyon reflects on the evolution of the longevity field over the 30 years since the publication of her groundbreaking paper, “A C. elegans mutant that lives twice as long as wild type,” a genetic analysis of one of the first single-gene mutations to extend lifespan in the worm. She recounts the initial excitement and skepticism around the idea of a pathway that regulates aging, and subsequent validation of this and related ideas in a wide range of model organisms. She also discusses her longstanding belief in the translational potential to improve human healthspan, and her experience as a co-founder of one of the first longevity biotech startups, Elixir Pharmaceuticals, in 1999. Based on her unique historical perspective—and with undiminished enthusiasm—she looks ahead to the unsolved mysteries that will propel the next generation of breakthroughs.

Key ideas:

• Origins of looking at aging regulation in C. elegans in the 1990s
• age-1 and daf-2 as the first aging genes
• Early resistance to the idea of studying aging at the molecular level
• Cloning of genes to reveal conserved longevity pathways (IIS/mTOR)
• Extending lifespan in invertebrates, and then mice
• The connection between stress resistance to evolutionary theory
• Dr. Kenyon's initial belief in the translatability of aging science
• Co-founding Elixir Pharmaceuticals in 1999 to target aging
• Current optimism about interventions against aging
• Need for public funding of large trials of natural compounds
• Excitement about newest mechanisms like reprogramming
• The enduring promise of targeting core nutrient-sensing networks
• Developmental origins of aging rates and resilience

Links: 

Email questions, comments, and feedback to [email protected]

Translating Aging on Twitter: @bioagepodcast

BioAge Labs Website bioagelabs.com

BioAge Labs Twitter @bioagelabs

BioAge Labs LinkedIn

Dr. Jamie Justice is Executive Director of the newly launched XPRIZE Healthspan, a $101 M international competition to accelerate therapeutics targeting aging biology. In conversation with host Chris Patil, Dr. Justice outlines the motivation, structure, and timeline of the prize, as well as how teams can get involved. She also explains unique aspects of this prize, including the public commentary period, how existing trials can be adapted for competition, functional endpoints, and judging criteria. She also conveys why coordination is needed to overcome barriers and drive investment in longevity R&D. Listeners will gain key insights into this ambitious initiative to catalyze progress translating research into treatments for aging.

Key ideas:

• Why aging solutions need acceleration despite increased attention
• The role and track record of incentive competitions like XPRIZE
• Motivation and sponsors enabling XPRIZE Healthspan ($101M purse)
• Timeline from conceptualization to upcoming 7-year active competition
• Expert endpoint committee setting measurable functional criteria
• Initial public commentary period for radical collaboration with teams
• Phases: Intent to compete, qualifying submissions, finalist selection
• Existing prevention trials can add program assessments
• Common data and protocols to validate findings across teams
• Goal of demonstrating restoration of function across domains
• Secondary judging criteria around accessibility, biomarkers
• Driving global coordination, investment, and innovation

Links: 

XPRIZE Healthspan

Email questions, comments, and feedback to [email protected]

Translating Aging on Twitter: @bioagepodcast

BioAge Labs Website bioagelabs.com

BioAge Labs Twitter @bioagelabs

BioAge Labs LinkedIn

Dr. Coleen Murphy is a prominent aging researcher and author of the upcoming book “How We Age: The Science of Longevity” from Princeton University Press. In this wide-ranging discussion, Coleen provides insights into her motivation for writing this book, key topics covered, and her unique perspective on the field. 

Key ideas:

• Addressing ethical concerns about studying aging and longevity
• Defining aging conceptually and how metrics like lifespan vs. healthspan are measured
• Using genetics, transcriptomics and other tools to understand molecular changes in aging
• The prominent role of reproduction and sex differences in aging
• Theories on tradeoffs between reproduction and longevity
• Genetics of aging pathways including insulin/IGF-1, mTOR, and sirtuins
• Cellular processes involved in aging such as mitochondrial dysfunction, epigenetic changes, senescence
• The importance of models like C. elegans and Drosophila in aging research
• Ongoing research and future potential for interventions to increase healthspan
• The challenge of complex science without excessive jargon
• Highlighting critical contributions by women scientists in the field
• Omitting personal lifestyle advice and focusing on evidence-based science
• The rapid pace of advancement in biotech applications of longevity science

Links: 

Email questions, comments, and feedback to [email protected]

Translating Aging on Twitter: @bioagepodcast

BioAge Labs Website bioagelabs.com

BioAge Labs Twitter @bioagelabs

BioAge Labs LinkedIn

Dr. Nicholas Hertz is the co-founder and former CSO of Mitokinin, a biotech company developing therapies targeting damaged mitochondria in neurodegenerative disease. Mitokinin was recently acquired by pharmaceutical giant AbbVie. In this episode, Nick recounts the journey from academic research on PINK1 biology to founding a startup and advancing a clinical candidate. He provides insights into the drug discovery process, optimizing lead compounds, translating basic findings into therapies, and partnering with big pharma. Nick also shares lessons learned along the way about focusing on robust science, being adaptable, and maintaining ambition to help patients.

Key topics covered:

• Background on Mitokinin’s approach of activating PINK1 to clear damaged mitochondria
• Founding a company based on academic research and discoveries
• Navigating from tool compounds to optimizing in vivo activity and drug properties
• Using mitochondrial biomarkers like phospho-ubiquitin to track target engagement
• Partnering with AbbVie: alignment on science, IP transfer after acquisition
• Importance of reproducibility, following the science to clinic-ready agents
• Planning the next neurodegeneration startup based on past experience
• Advice for startups: pick projects wisely, focus on robust science over hype

Notable Quotes: (edited slightly for clarity and length)

"What PINK1 does is signal when mitochondria have gone bad and need to be cleared away."

"Seeing PINK1 mutations lead to early Parkinson's cemented the link between mitochondrial health and neurodegeneration."

"The biggest challenge was getting enough brain exposure and potency for in vivo efficacy."

"We developed assays to measure phospho-ubiquitin levels in patient samples and use it as a pharmacodynamic marker."

"With AbbVie, we were aligned on making a safe drug you'd feel comfortable giving to your own family."

"I enjoyed the journey more than the destination. Now I want to get back in the lab and do more science."

"Focus on projects you believe in and doing the most robust, reproducible science."

"I consider failing to help patients in Phase 3 trials a failure, even if you already exited successfully."

Links: 

Mitokinin website (this link may become obsolete as Mitokinin becomes part of AbbVie)

Email questions, comments, and feedback to [email protected]

Translating Aging on Twitter: @bioagepodcast

BioAge Labs Website bioagelabs.com

BioAge Labs Twitter @bioagelabs

BioAge Labs LinkedIn

Dr. Alex Colville is the co-founder and General Partner of Age1 Ventures, a recently launched VC firm focused on funding contrarian, founder-led biotech companies aiming to extend healthy human lifespan. In this episode, Alex outlines Age1's thesis of identifying and empowering talented founders with ambitious visions for the longevity field. He shares his own journey to VC, including early interests in aging science and entrepreneurship. Alex provides an inside look at Age1's approach to community building, sourcing high-potential founders, investing at the pre-seed/seed stage, and supporting companies technologically and strategically. He also discusses Age1's very first investment in Aperture Therapeutics. Listeners will gain insights into how Age1 aims to catalyze change in the longevity biotech ecosystem.

Key topics covered:

• Origins of Age1 in the pioneering Longevity Fund and Laura Deming's vision
• Alex's path from aging researcher to VC investor and community builder
• How VCs raise funds from different types of investors (LPs)
• Age1's focus on early-stage companies and contrarian, ambitious founders
• Sourcing and identifying high-potential founders through networks and events
• The importance of founder motivation and pragmatism in Age1's investments
• Age1's first investment in Aperture Therapeutics targeting neuroinflammation
• Unique value-add Age1 provides with specialized aging expertise
• Empowering founders by showing people "like them" can build startups
• Age1's moonshot goal of enabling agency over healthspan and lifespan

Notable Quotes:

(quotes have been lightly edited for clarity)

"A fund is a vehicle of money devoted to making investments to return capital with more money than you started with."

"Once you have the money, your focus becomes finding the best founders and supporting them to increase the odds of success."

"The best founders don't necessarily realize they could be a founder. We can help show people they can just dive in."

"What matters most to us is not the idea, but the founder and their potential."

"We want somebody with a very strong mission motivation towards aging. This core focus ends up being a huge strength of the company."

"We look for a combination of pragmatism and moonshot mentality."

"Our goal is to give people agency over how long they live in good health.”

“Age1 needs to exist in order to convince some of the raw, ambitious talent that they can do things they don't yet know that they can do—in order to pull off moonshots.”

Links: 

Age1

Alex’s recent paper

Email questions, comments, and feedback to [email protected]

Translating Aging on Twitter: @bioagepodcast

BioAge Labs Website bioagelabs.com

BioAge Labs Twitter @bioagelabs

BioAge Labs LinkedIn

Dr. Carolina Reis Oliveira and Dr. Alessandra Zonari are the co-founders of OneSkin, a company developing science-backed skincare products to reverse skin aging at the cellular level. In this episode, Carolina and Alessandra tell host Dr. Chris Patil how OneSkin is leveraging recent advances in longevity science to create novel peptides that target senescent cells and inflammation in aged skin. Their lead ingredient, OS-1, is a peptide capable of reducing biological age and senescence burden in human skin models.They explain their rigorous discovery process, including screening peptide libraries in cellular models of skin aging, which were described in a recent paper in Nature Aging. Next, they share how they translated this scientific research into an effective, consumer-friendly skincare product line and brand. Listeners will gain insights into OneSkin's unique approach bridging cosmetics and cutting-edge geroscience.

Key topics:

• Why skin health and appearance are important markers of overall aging
• The cellular and molecular changes underlying skin aging
• How most skincare products focus on temporary effects vs. targeting root causes
• Screening peptide libraries in cellular models to discover senolytic/senomorphic candidates
• Discovery and testing of lead peptide OS-1 in 3D skin models and human trials
• Validating safety and efficacy to meet cosmetics regulatory requirements
• Launching a science-backed skincare brand and resonating with educated consumers
• Ongoing R&D to expand into new anti-aging applications and delivery methods

Quotes:

Quotes have been lightly edited for clarity.

"Obviously, we look at our skin from the lens of aesthetics or of beauty. But our skin is our largest organ, and its main function is to protect our whole body against pathogens and different types of environmental stressors. As the skin ages and deteriorates, the function also gets compromised."

“That's one of the things that we're interested in and exploring at OneSkin: not only how to improve your appearance, but also how to improve your skin function so it can aid in your overall health.”

"We realized none of the products out there were developed with the rationale of targeting aging itself."

"When we treat dermal fibroblasts with this peptide, we could decrease the amount of senescent cells by 40–50%."

"More and more, the population is getting educated. They don't want just marketing claims, they want to understand and trust brands that can really bring proof."

"People are more open to say, okay, if I need to put something on my skin, I should use a company that's actually doing real science."

"Our primary goal is to continue to be the most innovative company when it comes to skin aging, and to continue to be at the forefront of aging research applied to skin."

Links: 

Email questions, comments, and feedback to [email protected]

Translating Aging on Twitter: @bioagepodcast

BioAge Labs Website bioagelabs.com

BioAge Labs Twitter @bioagelabs

BioAge Labs LinkedIn

OneSkin company page

Nature Aging paper

Dr. Felix Wong is a co-founder of Integrated Biosciences, an early-stage biotech company developing next-generation therapeutics for cellular rejuvenation. He is also a postdoc at MIT and the Broad Institute and was a lead author on a recent Nature Aging paper describing the use of graph neural networks to discover new senolytic compounds.

In this episode, Felix and host Chris Patil have an in-depth discussion about using machine learning to accelerate drug discovery, specifically to target cellular senescence. They explore how graph neural networks were trained on screening data to evaluate large chemical spaces and identify new senolytic molecules with medicinal properties superior to those of previously known compounds.

Key topics:

• What cellular senescence is and why selectively eliminating senescent cells may have therapeutic benefits for aging and age-related diseases
• Limitations of traditional high-throughput screening approaches and the vastness of chemical space
• How graph neural networks work and how Felix’s team trained them on senolytic screening data
• Applying the models to search much larger chemical libraries and identify promising new senolytic scaffolds
• Experimental validation and characterization of hits from the AI screening
• The potential to use this machine learning approach more broadly for phenotypic drug discovery
• Felix’s new company Integrated Biosciences and their mission to control cellular stress responses using synthetic biology and AI

Quotes:

Quotes have been lightly edited for clarity.

"We found that machine learning models might allow us to more productively search chemical space and increase our working hit rates."

"What was fascinating to us about senescence cells is that, unlike other pathologies or diseases, these cells are not really characterized by a single target."

"The quality of any machine learning model is limited by the quality of the training data. And that in turn is limited by how good your screens are, and how good your understanding of the biology is."

“That's really what machine learning is doing, trying to think about things in a very high dimensional manner. And then trying to build models that help to separate what is positive and what is negative.”

“So what ideally we would want is for any model to be able to generalize, to be able to predict chemical scaffolds that the model has not previously seen, and positively identify those scaffolds as new senolytics.”

"Ideally, we would like to treat aging and age-related diseases, just like how antibiotics treat bacterial infections."

“At Integrated, we're trying to kind of look at these stress responses holistically. We think that senescence is only a piece of the bigger puzzle.”

Links: 

Email questions, comments, and feedback to [email protected]

Translating Aging on Twitter: @bioagepodcast

BioAge Labs Website bioagelabs.com

BioAge Labs Twitter @bioagelabs

BioAge Labs LinkedIn

Integrated Biosciences

Joan Mannick, CEO and co-Founder of Tornado Therapeutics, joins the podcast to discuss her company’s exciting mission of developing a new generation of rapalog compounds specifically targeting the TORC1 complex. Rapalogs are analogs of the natural compound rapamycin, which has been shown to extend lifespan and healthspan in animal models by inhibiting the TOR pathway. However, rapamycin has limitations that have prevented its widespread clinical use for aging-related conditions.

Tornado aims to overcome these limitations by developing a portfolio of novel rapalogs licensed from Novartis, which were specifically designed to be more selective TORC1 inhibitors with improved drug-like properties relative to rapamycin. Early data suggests these compounds may have an improved safety profile and remain effective at treating diseases like cancer.

In her conversation with host Chris Patil, Dr. Mannick provides an accessible overview of TOR signaling biology and shares insights from her extensive experience developing rapalogs. The discussion covers Tornado’s strategic approach to indications like oncology and viral infections, the process of characterizing their licensed compounds, and notable milestones on the horizon.

Dr. Mannick provides an insider perspective on a compelling longevity biotech company striving to translate the promise of rapalogs into effective medicines for age-related diseases.

Key topics:

• An overview of the TOR signaling pathway, the TORC1 and TORC2 complexes, and how the natural compound rapamycin inhibits TOR function.
• The benefits and limitations of using rapamycin/rapalogs clinically, and the need for more selective TORC1 inhibitors with improved drug properties.
• Tornado’s licensing of novel TORC1-specific rapalogs from Novartis, including early safety data.
• Indications that Tornado is initially pursuing, including oncology and viral infection, applying lessons learned about rapalogs over the past decade.
• The experience of being a “pipeline company” within the Cambrian Biopharma family, and the synergies available to companies operating within this model.
• The maturation of the longevity biotech field
• Promising milestones on Tornado’s horizon.

Quotes:

Quotes have been lightly edited for clarity.

"Rapamycin is a very specific inhibitor of this critical protein mTOR that regulates lifespan and healthspan."

“An ideal rapalog to treat aging-related conditions and extend lifespan is predicted to be a rapalog that specifically inhibits TORC1, but leaves TORC2 alone.”

"The problem with rapamycin is that it has no remaining patent life. And we really have to do the studies to see if the benefit outweighs the risks."

“[Cambrian] enabled me to go very fast in terms of execution - you get a team, which is very rare when you start a startup.”

"Longevity medicine is white space ready to be explored. It's an untapped area that could transform the practice of medicine."

“We are picking indications where there's not just preclinical validation, but a lot of clinical validation.”

“We're going to use these lessons learned to see if with a better clinical development plan, we can now develop our next generation rapalogs to enhance antiviral immunity and decrease severity of viral respiratory tract infections.”

Links: 

Email questions, comments, and feedback to [email protected]

Translating Aging on Twitter: @bioagepodcast

BioAge Labs Website bioagelabs.com

BioAge Labs Twitter @bioagelabs

BioAge Labs LinkedIn

Tornado Therapeutics