Hosts: Vincent Racaniello, Michael Schmidt, Elio Schaechter and Jo Handelsman.  

The TWiM team celebrates 100 episodes with a Talmudic question, and discussion of how a single mutation alters bacterial host tropism.

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Image: Yellow colonies of S. aureus on a blood agar plate, note regions of clearing around colonies caused by lysis of red cells in the agar By: HansN. on wikimedia. From the study (Nat Gen) "...only a single naturally occurring nucleotide mutation was required and sufficient to convert a human-specific S. aureus strain into one that could infect rabbits."