In his weekly clinical update, Dr. Griffin discusses coverage with selected vaccines and exemption from school vaccine requirements among children in kindergarten, seasonality of endemic COVID-19, mRNA SARS-CoV-2 vaccination before vs during pregnancy and omicron infection among infants, extracting symptoms from free-text responses using ChatGPT among COVID-19 cases in Hong Kong, SARS-CoV-2 virologic rebound with nirmatrelvir–ritonavir therapy, optimization of antiviral therapy in immunocompromised COVID-19 patients, a study to learn about the study medicines (nirmatrelvir plus ritonavir) in people aged 12 years or older with COVID-19 and a compromised immune system, evaluation of the safety profile and therapeutic efficacy of Remdesivir in children with SARS-CoV-2 infection, effect of neutralizing monoclonal antibody treatment on early trajectories of virologic and immunologic biomarkers in patients hospitalized with COVID-19, and SARS-CoV-2 virologic rebound with nirmatrelvir–ritonavir therapy.

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Links for this episode

• Coverage with selected vaccines and exemption from school vaccine requirements among (CDC)
• Seasonality of endemic COVID-19 (Virology)
• mRNA SARS-CoV-2 vaccination before vs during pregnancy and Omicron infection among infants (JAMA)
• Extracting symptoms from responses using ChatGPT among COVID-19 cases (CMI)
• SARS-CoV-2 virologic rebound with nirmatrelvir–ritonavir therapy (AIM)
• Optimization of antiviral therapy in immunocompromised COVID-19 patients (ClinicalTrials)
• A study to learn about nirmatrelvir/ritonavir in people with COVID-19 and a compromised immune system (ClinicalTrials)
• Evaluation of the safety profile and therapeutic efficacy of remdesivir in children with SARS-CoV-2 infection (EJP)
• Effect of neutralizing monoclonal antibody treatment on virologic and immunologic biomarkers in patients with COVID-19 (JID)
• SARS-CoV-2 virologic rebound with nirmatrelvir–ritonavir therapy (AIM)
• Contribute to our MicrobeTV fundraiser at PWB
• Letters read on TWiV on TWiV 1062
• Dr. Griffin’s COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]