This Week in Virology

TWiV 1092: Clinical update with Dr. Daniel Griffin


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In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of respiratory syncytial virus, influenza and SARS-CoV-2 before discussing new vaccine guidelines released by the advisory committee on immunization practices, and reviews the CDC guidelines for quarantine/ isolation following SARS-CoV-2 infection, continues to dispel the myth of viral rebound, how to pay for paxlovid, when to use steroids and the benefits of convalescent plasma, the role of IFN-g in long COVID, if the brain-blood-barrier is compromised in long COVID, meaning of persistent community SARS-CoV-2 RNA findings, and the effects of hyperbaric oxygen on post COVID neurocognition.

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Links for this episode
  • Respiratory disease surveillance (CDC)
  • RSV surveillance  (CDC)
  • RSV national trend (CDC)
  • RSV vaccination stats (CIDRAP)
  • Influenza/flu surveillance  (CDC)
  • Influenza/flu map (CDC)
  • COVID-19  hospital admissions (CDC)
  • COVID-19 national trend (CDC)
  • COVID-19 wastewater testing (biobot)
  • Variant tracker (CDC)
  • Variant hospital admissions (CDC)
  • ACIP COVID vaccination for seniors recommendations (CIDRAP)
  • Additional vaccine doses for older adults (CDC)
  • Evidence based advice from the ACIP (CDC)
  • State mandates did NOT influence primary vaccination rates only boosters (PNAS)
  • No nOPV2? (CDC)
  • CDC Quarantine guidelines (CDC)
  • To rebound or to not rebound (MMWR)
  • Know your COVID-19 tools (ESMED)
  • How to pay for Paxlovid (PAXCESS)
  • Molnupiravir safety and efficacy (JMV)
  • Molunpiravir plus antibody therapy for at-risk outpatients (Nat Comm)
  • Convalescent plasma recommendation for immunocompromised (IDSociety)
  • Steroids, dexamethasone at the right time (OFID)
  • Anticoagulation guidelines (hematology.org)
  • Spontaneous release of IFN-g in Long COVID (Science Advances)
  • Blood-brain-barrier compromise in long COVID associated cognitive impairment (Nat Neuroscience)
  • Persistent community SARS-CoV-2 RNA (Nature)
  • Hyberbaric oxygen therapy improves post COVID neurocognition (Scientific Reports)
  • Medical study questionnaire, the SHORT form (Brandeis)
  • Long term effects of hyperbaric oxygen post COVID (Scientific Reports)
  • Contribute to our ASTMH fundraiser at PWB
  • Letters read on TWiV 1092
  • Dr. Griffin’s COVID treatment summary (pdf)
  • Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]

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