In his weekly clinical update, Dr. Griffin deep dives into the durability of the antibody response following mpox vaccination, vaccine security, global mpox circulation, the origins of SARS-CoV-2, including a list TWiV episodes and combatting scientific misinformation, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, where to find PEMGARDA, a reminder of how and when to use steroids to treat COVID-19, what do when healthcare workers succumb to SARS-CoV-2 infection, if remdesivir + dexamethasone lowers mortality of hospitalized COVID-19 patients and the finding of how SARS-CoV-2 infection impacts memory and cognition.

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Links for this episode

• Waning vaccine protection against mpox…..isn’t this the way the humoral immune response works? (CIDRAP) 1:46
• Uncontrollable mpox outbreak in Africa  (Reuters) 4:10
• Antibodies elicited by the Jynneos vaccine against mpox contract after 6-9 months….can you believe? (medrxiv) 4:45
• Mpox vaccine for adolescents approved (Pharmaceutical Technology) 14:05
• Clade 1b mpox visiting India (CIDRAP) 15:05
• Mpox clade 1b in Kerala (ANI South Asia’s Leading Multimedia News Agency) 15:13
• US government orders $63M worth of small pox/mpox vaccine (Reuters) 15:34
• Mpox donations boosting global supply (US Department of Health and Human Services)
• 1 million mpox vaccine doses for Africa….with love from US government (CIDRAP) 15:55
• Speed doses of mpox vaccine (CIDRAP)
• Mpox vaccine donations (UNICEF) 17:35
• Bavarian Nordic mpox vaccine (Yahoo finances)
• Early epicenter of COVID-19 pandemic Huanan seafood market (Science) 23:07
• Wildlife trade likely source of SARS-CoV-2 (Science) 23:16
• Zoonotic origins of SARS-CoV-2 (Science) 23:20
• Surveillance at the Huanan Seafood market (Europe PMC) 25:03
• TWiV shout outs…..all for the SARS-CoV-2 spill over from nature 25:31
  • TWiV 1019: Eddie Holmes on SARS-CoV-2 origins
  • TWiV 1017: From Nature, not a lab
  • TWiV 995: Viral origin stories
  • TWiV 940: Eddie Holmes in on viral origins
  • TWiV 876: Spillover market with Michael Worobey
  • TWiV 762: SARS-CoV-2 origins with Robert Garry
  • TWiV 760: SARS-CoV-2 origins with Peter Daszak, Thea Kølsen Fischer, Marion Koopmans
  • TWiV 774: Kristian Andersen, Robert Garry, and the deleted SARS-CoV-2 sequences
• Genetic tracing of market wildlife and viruses at Huanan Market (Cell) 18:56
• Combatting scientific misinformation (microbeTV: TWiV) 34:14
• COVID-19 deaths (CDC) 35:20
• COVID-19 national and regional trends (CDC)
• Waste water scan for 11 pathogens (WastewaterSCan)
• COVID-19 variant tracker (CDC)
• SARS-CoV-2 genomes galore (Nextstrain)
• Suggestion for the use of a new preventive COVID-19 agent (IDSA)
• IDSA Guidelines on the Treatment and Management of Patients with COVID-19 (IDSA)
• Where to get pemgarda (Pemgarda)
• EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD)
• CDC Quarantine guidelines (CDC)
• NIH COVID-19 treatment guidelines (NIH)
• Infectious Disease Society guidelines for treatment and management (ID Society)
• Drug interaction checker (University of Liverpool)
• Molnupiravir outcomes 3 and 6 months after treatment (LANCET Infectious Diseases)
• Antivirals and post-COVID-19 conditions (LANCET Infectious Disease)
• Molnupiravir safety and efficacy (JMV)
• Convalescent plasma recommendation for immunocompromised (ID Society)
• What to do when sick with a respiratory virus (CDC)
• When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC)
• Managing healthcare staffing shortages (CDC)
• Steroids, dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• Lower mortality risk associated with remdesivir + dexamethasone versus dexamethasone for hospitalized COVID-19 patients (CID) 39:17
• Changes in memory and cognition during the SARS-CoV-2 human challenge study (eClinical Medicine) 42:25
• Letters read on TWiV 1152 48:18
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]