From the 2025 annual meeting of the American Society for Virology, Charlie Rice, 2020 Nobel Laureate in Physiology or Medicine, talks with Vincent and Kathy about his career and the scientific difficulties he and his laboratory encountered in their attempts to achieve replication of hepatitis C virus in cells in culture.

Hosts: Vincent Racaniello and Kathy Spindler

Guest: Charlie Rice

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Links for this episode

• Support science education at MicrobeTV
• 2020 Nobel Prize (Nobel Prizes)
• Hepatitis C human challenge study (Lancet Gastro Hepatol)
• Rat hepacivirus mouse model for hepatitis C (Hepatol)
• Replication of hepatitis C virus in cells in culture (Science)
• Lessons from domestication of HCV (Curr Opin Virol)

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

Content in this podcast should not be construed as medical advice.