In COVID-19 clinical update #93, Dr. Griffin summarizes Omicron fitness, S-gene target failure, monoclonal efficacy against Omicron, vaccination, monoclonals, and disease in children, persistence of memory B cells in the elderly, infection and vaccine induced immunity, protection against severe illness and death by a third mRNA vaccine dose, high flow oxygen versus intubation, and therapeutic anticoagulation. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Variant updates (CDC) List of diagnostic kits (Global Fund, pdf) B1.1.529 escapes most antibodies (bioRxiv) mRNA vaccine third dose and Omicron (medRxiv) Outpatient strategies children and adolescents (AAP) Memory B cells persist in elderly (J Clin Invest) mRNA booster effect against Delta (Clin Inf Dis) Azithromycin meta-analysis (J Antimicrob Chemo) High-flow oxygen vs intubation (JAMA) Therapeutic anticoagulation (Ann Int Med) Africa cases surge (CIDRAP) Letters read on TWiV 843 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]