For the final episode of 2021, TWiV reviews an experimental infectious attenuated Lassa fever vaccine based on a codon-deoptimized glycoprotein gene, and SARS-CoV-2 infection of free-ranging white-tailed deer. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Codon-deoptimized Lassa fever vaccine (mBio) Attenuation of dengue virus by codon deoptimization (TWiV 351) Codon deoptimization of poliovirus and RS virus (TWiV 740) Codon deoptimization of DNA viruses (TWiV 362 letters) CEPI on TWiV 612 SARS-CoV-2 in white-tailed deer (Nature) Letters read on TWiV 847 Timestamps by Jolene. Thanks! Weekly Picks Dickson – EO Wilson (Ants and The Conversation) Brianne – The Best Fun Science Stories of 2021 Kathy – Using sound for data analysis; chemotactic bacteria and Moo loo story Alan – Owls of the Easern Ice, by Jonathan Slaght Vincent – TWiV 9: Fever! The discovery of Lassa virus and TWiV 548: Mice, shrews, and caterpillars Listener Picks Larry – Immunity Jeff – Daily Hospital Surveillance Report Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]