In his weekly clinical update Dr. Griffin discusses the political polarization of COVID-19 treatments among physicians and laypeople in the United States, seven alternatives to evidence-based medicine, Malawi’s cholera death toll crosses 1,300 in its deadliest outbreak on record, impact of coronavirus infections on pediatric patients at a tertiary pediatric hospital, maternal mRNA COVID-19 vaccination during pregnancy and delta or omicron infection or hospital admission in infants, yes masks reduce the risk of spreading infection, despite a review saying they don’t, COVID-19 and airborne transmission: science rejected, lives lost. can society do better, what were the historical reasons for the resistance to recognizing airborne transmission during the COVID-19 pandemic, a randomized trial comparing Omicron-containing boosters with the original COVID-19 vaccine mRNA-1273, SARS-CoV-2 neutralizing antibodies after bivalent vs. monovalent booster, the impacts of SARS-CoV-2 vaccine dose separation and targeting on the COVID-19 epidemic in England, intra-host evolution provides for the continuous emergence of SARS-CoV-2 variants, real-world use of Nirmatrelvir–Ritonavir in outpatients with COVID-19 during the era of Omicron variants including BA.4 and BA.5 in Colorado, viral burden rebound in hospitalized patients with COVID-19 receiving oral antivirals in Hong Kong, and guidance on the use of convalescent plasma to treat immunocompromised patients with COVID-19. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode The political polarization of COVID-19 treatments in the United States (PNAS) Seven alternatives to evidence-based medicine (BMJ) Malawi’s cholera death toll crosses 1,300 (CBC) Impact of coronavirus infections on pediatric patients (JHI) Maternal mRNA COVID-19 vaccination during pregnancy (BMJ) Yes, masks reduce the risk of spreading COVID (TVO) COVID-19 and airborne transmission (IDSA) What were the reasons for resistance to recognizing airborne transmission (IJIE) Comparing Omicron-containing boosters with COVID-19 vaccine mRNA-1273 (medRxiv) SARS-CoV-2 neutralizing antibodies after bivalent vs. monovalent booster (bioRxiv) The impact of SARS-CoV-2 vaccine dose separation and targeting (Nature) Intra-host evolution provides for the emergence of SARS-CoV-2 variants (ASM) Real-world use of nirmatrelvir–ritonavir in outpatients with COVID-19 (The Lancet) Viral rebound in hospitalized patients with COVID-19 receiving oral antivirals (The Lancet) Guidance on the use of convalescent plasma to treat immunocompromised patients with COVID-19 (CID) Contribute to our ASTMH fundraiser at PWB Dr. Griffin’s treatment guide (pdf) Letters read on TWiV 984 Don’t crush Paxlovid (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]