Scott returns to TWiV to explain the development of an experimental mRNA vaccine that encodes hemagglutinin antigens against all known influenza A virus subtypes and influenza B virus lineages, and why he is worried about avian H5N1 influenza virus. Hosts: Vincent Racaniello, Dickson Despommier, and Brianne Barker Guest: Scott Hensley Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode •Research assistant position at FDA (pdf) •Register for ASV 2023 •MicrobeTV Discord Server •Multivalent influenza mRNA vaccine (Science) •Influenza virus mRNA vaccines circumvent egg adaptation problems (J Virol) •Letters read on TWiV 983 •Timestamps by Jolene. Thanks! Weekly Picks Dickson – Jazz Project:  Guitar. Django Reinhardt; Pat Metheny. Signature album: Still Life Talking. Signature song: Last Train Home; Joe Pass (Ella Fitzgerald’s favorite guitar accompanist). Signature album: Virtuoso. Signature song: Round Midnight. Brianne – HHMI Virus Explorer Vincent – Chris Luno Listener Picks John – White-tail deer density and SARS-CoV-2 in white-tail deer Jessica – Classic cases revisited: Oscar the cat and predicting death Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

TWiV 983: One flu vaccine for them all with Scott Hensley

This Week in Virology is a netcast about viruses - the kind that make you sick.

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TWiV rebuts a recent opinion piece which falsely claims that the COVID-19 pandemic began in a lab (it began in Nature). This material has been extracted from TWiV 1121. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Brianne Barker, and Jolene Ramsey Subscribe (free):  Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode  MicrobeTV Discord Server SARS-CoV-2 origin discussions previously on TWiV:  TWiV 1019: Eddie Holmes on SARS-CoV-2 origins TWiV 1017: From Nature, not a lab TWiV 995: Viral origin stories TWiV 940: Eddie Holmes in on viral origins TWiV 876: Spillover market with Michael Worobey TWiV 762: SARS-CoV-2 origins with Robert Garry TWiV 760: SARS-CoV-2 origins with Peter Daszak, Thea Kølsen Fischer, Marion Koopmans TWiV 774: Kristian Andersen, Robert Garry, and the deleted SARS-CoV-2 sequences   Why the Pandemic Probably Started in a Lab, in 5 Key Points (NY Times) Timestamps by Jolene. Thanks!  Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.

TWiV Special: How the pandemic began in Nature, in 5 key points

TWiV rebuts a recent opinion piece which falsely claims that the COVID-19 pandemic began in a lab (it began in Nature), followed by a discussion of Paride bacteriophage, which has the unsual property of being able to kill dormant, antibiotic-tolerant cells by direct lytic replication. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Brianne Barker, and Jolene Ramsey Subscribe (free):  Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode  MicrobeTV Discord Server 2024 International HBV Meeting Register for ASV Annual Meeting SARS-CoV-2 origin discussions previously on TWiV:  TWiV 1019: Eddie Holmes on SARS-CoV-2 origins TWiV 1017: From Nature, not a lab TWiV 995: Viral origin stories TWiV 940: Eddie Holmes in on viral origins TWiV 876: Spillover market with Michael Worobey TWiV 762: SARS-CoV-2 origins with Robert Garry TWiV 760: SARS-CoV-2 origins with Peter Daszak, Thea Kølsen Fischer, Marion Koopmans TWiV 774: Kristian Andersen, Robert Garry, and the deleted SARS-CoV-2 sequences   Why the Pandemic Probably Started in a Lab, in 5 Key Points (NY Times) Phage Paride kills dormant, antibiotic-tolerant cells of Pseudomonas aeruginosa (Nat Comm) Interview with Enea Maffei (Spotify) Timestamps by Jolene. Thanks!  Weekly Picks Brianne – How to build a nuclear warning for 10,000 years’ time Rich – Doctor My Eyes | Jackson Browne Alan – WHO Health for All Film Festival winners Jolene – El enemigo de mi enemigo es mi amigo Vincent – A Population Dotmap of New York City and Race and Ethnicity in New York City Listener Picks David – The greatest clock (and map) ever made Peter – The Mouse as a Microscope Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

TWiV 1121: SARS-CoV2 still didn't come from a lab

In his weekly clinical update, Dr. Griffin reports the third case of influenza H5N1 infection in a human, this time with respiratory symptoms, an H5 avian influenza virus wastewater dashboard, FDA approves Moderna’s mRNA vaccine for respiratory syncytial virus, vaccine advisors to FDA recommend switching from the XBB.1.5 variant to JN.1 for fall COVID-19 vaccine formulations, weekly US COVID update, a controlled human exhaled breath aerosol experimental study on the relative efficacy of masks and respirators as source control for viral aerosol shedding from people infected with SARS-CoV-2, systematic review of early use of oral antiviral drugs and the risk of post COVID-19 syndrome, long-COVID autonomic syndrome in working age and work ability impairment, Centers for Disease Control and Prevention estimates that 5.3% of Americans currently have long COVID, and the National Academies of Sciences, Engineering, and Medicine presented a report with  a number of conclusions about long-COVID diagnosis, symptoms, and impact on daily function. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV!  Links for this episode   More cattle and dairy workers infected with highly pathogenic H5N1 in  Michigan (CDC Newsroom)   Not eye but respiratory human H5N1 in Michigan (CIDRAP)  Emory and Stanford’sH5N1 dashboard (Emory and Stanford)   FDA approval for MRESVIA(FDA)   Moderna RSV vaccine for the elderly (CIDRAP)   Moderna announces approval of MRESVIA (moderna)   FDA VRBPAC meeting for fall COVID boosters (FDA)   JN.1 variant for fall booster (CIDRAP)  COVID-19 national trend (CDC)  COVID-19  deaths (CDC)  Masks and respirators for  source control from viral aerosol shedding (Lancet)  Spring vaccine  advice (CIDRAP)   Older adult spring booster available (CDC)  Advisory committee for immunization practices  slides (CDC)   EUA for pemgarda (FDA)   Where to get pemgarda (Pemgarda)   CDC Quarantine guidelines (CDC)  Early phase of SARs-CoV-2 infection (COVID.gov)   NIH COVID-19 treatment guidelines (NIH)   Infectious Disease Society guidelines for treatment and management (ID Society)  Drug interaction checker (University of Liverpool)  Molnupiravir safety and efficacy (JMV)  Convalescent plasma recommendations for immunocompromised (IDSociety)  Updated  respiratory virus guidances (CDC)  What to do when your healthcare provider is infected with SARS-CoV-2 (CDC)  Managing healthcare staffing  shortages (CDC)  Steroids,  dexamethasone at the right time (OFID)   Anticoagulation guidelines (hematology.org)  Early use of  oral antiviral drugs and risk of long COVID (Journal of Infection)   Early antiviral use associates with low risk of long COVID (CIDRAP)  Long-COVID autonomic syndrome impairment (Scientific reports)  Autonomic nervous assessment tool (hATTR)  Do you know percentage of population with long COVID? (CDC National Center for Health Statistics)  How  many symptoms are there to long COVID? (CIDRAP)   Long-term health effects of long COVID (National Academies of Sciences Engineering Medicine)  Long COVID evidence based review TWiV shout out Contribute to our Floating Doctors  fundraiser  Letters read  on TWiV 1120 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene. Thanks!  Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV 1120: Clinical update with Dr. Daniel Griffin

TWiV reviews viral shedding and antibody responses of men with acute monkeypox virus infection, and gene editing for latent herpes simplex virus infection reduces viral load and shedding. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Angela Mingarelli Subscribe (free):  Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode  MicrobeTV Discord Server MicrobeTV store at Cafepress 2024 International HBV Meeting Michelson Prizes: Next Generation Grants Register for ASV Annual Meeting Monkeypox virus shedding (Nat Commun) Gene editing of herpes simplex virus (Nat Commun) Letters read on TWiV 1119 Timestamps by Jolene. Thanks!  Weekly Picks Angela – Unconventional Sex Let Anglerfish Conquer the Deep Ocean Kathy – Doonesbury from 5-26-24. And Publish or Perish game Rich – Sky: Giant Sunspot Region 3664 and Resulting Auroras APOD video  Vincent – Mysterious sea urchin plague is spreading through the world’s oceans Listener Pick Abdulaziz – Biomedical Scientist Answers Pseudoscience Questions Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.

TWiV 1119: Gene editing latent herpes

In his weekly clinical update, Dr. Griffin delves into highly pathogenic H5N1 infection of hunting dogs, dairy cattle, humans and alpacas before reviewing the recent statistics on SARS-CoV-2 infection, risks factors associated with the development of severe COVID-19 in pediatric patients, virus transmission on commercial airline flights, the guidelines for spring administration of COVID vaccines boosters, the emergency use application of a pre-exposure prophylactic, a drug interaction database, absence of durability of XBB.1.15 vaccine induced immunity and continues to dispel the myth of viral rebound, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, and discusses why development of long COVID should be included in the development of treatments for acute viral disease, if vaccination effects long COVID, structural impairment of brain during long COVID, how cognitive and respiratory function may be compromised in long COVID.  For more information about long COVID-19 listen to TWiV 1088 and for H5N1 in dairy cattle and unpasteurized milk TWiV 1117. Subscribe (free):  Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV!  Links for this episode   Bird dogs  infected with high pathogenic avian flu H5N1(AKC) Hunting dogs with antibodiesagainst influenza A (H5N1) (Emerging Infectious Diseases)  Dairy cattle and 2 humans infected with highly pathogenic avian influenza A (H5N1) (MMWR) Daisy, are you reading NEJM: cow’s milk infected with highly pathogenic avian influenza A (H5N1)?  (NEJM) Better yet, listen TWiV 1117: pol dances with RNA to learn if mice can transmit H5N1 to each other  Alpacasinfected with for highly pathogenic avian influenza A (H5N1) (CIDRAP) USDA is now inspecting for highly pathogenic avian influenza A (H5N1) in alpacas in Idaho (USDA APHIS) COVID-19 deaths COVID-19 national trend Risk factors for pediatric critical COVID-19 (JPIDS)  Kids and their underlying conditions for increased risk for severe COVID-19 (CIDRAP) SARS-CoV-2 transmission during airline flights (Environmental Research and Public Health) Spring vaccine advice(CIDRAP)  Older adult spring  booster available (CDC) Advisory committee for immunization practice slides(CDC) Really, durable immune response of XBB.1.5 vaccines against Omicron subvariants (NEJM)  EUA for pemgarda(FDA) Infusion centers near you! (pemgarda.com)  CDC quarantine guidelines (CDC) Early phase of SARS-CoV-2 infection (COVID.gov)  NIHCOVID-19 treatment guidelines (NIH)  Infectious Disease Society guidelinesfor treatment and management (IDSociety) Drug interaction checker (University of Liverpool) Molnupiravirsafety and efficiacy (JMV) Convalescent plasma recommendations for immunocompromised (IDSociety) Updated respiratory virus guidelines (CDC) What to do when your healthcare provider is infected with SARS-CoV-2 (CDC) Managing healthcare staff shortages (CDC) Steroids, dexamethasone at the right time (OFID)  Anticoagulation guidelines (hematology.org) Long COVID evidence based review TWiV shout out (TWiV 1088) Post COVID-19 following virus vaccination (Nat Comm)  Why include long COVID-19 when developing novel treatments for acute disease (JID) Cerebral microstructural alterations post COVID-19 cognitive, memory and fatigue (Nat Comm) Cognitive impairment prevalence and co-occurrence in children and young adults 12 months after Omicron infection (Brain) Persistent static lung hyperinflation and small airway dysfunction in long COVID (Respiratory Research) Long COVID evidence based review TWiV shout out Contribute to our Floating Doctors fundraiser Letters read on TWiV 1118 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene. Thanks!  Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV 983: One flu vaccine for them all with Scott Hensley

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