In a two-part podcast, listen as Dr. H. Clifford Lane, National Institute of Allergy and Infectious Diseases, and Dr. Steven M. Gordon, Cleveland Clinic, join moderator Dr. Brian Mandell, Editor-in-Chief of Cleveland Clinic Journal of Medicine, to discuss vaccine hesitancy in the time of COVID. Topics discussed include the historical context of vaccine hesitancy, current knowledge and gaps regarding COVID-19 vaccines, and how to effectively guide patients in making informed decisions about COVID-19 vaccination.