Dr Guido Frank discusses his research in the use of ketogenic diets to treat anorexia nervosa. Although, his research is at an early stage his results appear do appear promising.

Anorexia is a disease which is one of the hardest psychiatric conditions of all to treat with a depressingly high mortality rate, so this work is of huge potential interest. Up to now, there has been no effective treatment for the disease and no medication has ever been approved for it. 

Guido believes the critical key to treatment may lie in uncovering what happens in the brain chemistry of anorexic patients when they starve themselves. He argues by stopping eating, they actually put themselves into a ketogenic state, which calms their brain and makes them less anxious. But this has the consequence of stopping them wanting to eat again. 

So Guido and his team wondered what would happen if they put anorexic patients into ketosis not by starvation, but  by feeding them a ketogenic diet.

In an initial small study five anorexic patients who had regained weight but still had major food anxieties and concerns, were put on a ketogenic diet. Normally, in patients like this the relapse rate is around 50%, but in this case, all four patients who remained on the diet stayed healthy and the researchers also saw a dramatic reduction in their eating concerns and phobias. And Guido is now in the process of recruiting patients for a new study.

So could this work offer a potentially successful approach to managing a  disease which has proved so intractable to treat?

The host of the podcast, Liz Tucker is an award winning medical journalist and former BBC producer and director.  You can follow Liz on Twitter at https://twitter.com/lizctucker and read her Substack newsletter about the podcast at https://liztucker.substack.com

If you would like to support this podcast you can do so via Patreon at https://www.patreon.com/WhatYourGPDoesntTellYou or via PayPal at https://www.whatyourgpdoesnttellyou.com/support/

What Your GP Doesn’t Tell You has been selected by Feedspot as one of the top 15 UK Medical Podcasts https://blog.feedspot.com/uk_medical_podcasts/

Laura Delano, was diagnosed as having bipolar disorder when she was a teenager and would go on to spent 13 years receiving psychiatric care, both as inpatient and outpatient. In the process,  she accumulated more and diagnoses, and was given more and more drugs. But - as she explains in her new book: Unshrunk – How the mental health industry took over my life and my fight to get it back, published by Monoray - there was a problem, Laura wasn’t getting better.

Despite being a high achieving student for whom it had once appeared a glittering future awaited, her life had fallen apart. She had dropped out of university, was unable to hold down a job and had tried to kill herself.

But then one day Laura had a life-changing epiphany - was it possible that rather than the care and medications she was receiving helping her,  might they actually be causing her problems?

Gradually over several years, she weaned herself off all her medication – no easy process given the withdrawal effect of many psychiatric drugs . But the impact was transformative and today Laura has completely turned her life around. 

So what went wrong with Laura's care?  And why was the medical system unable to recognise how the treatment was making her worse not better?

The host of the podcast, Liz Tucker is an award winning medical journalist and former BBC producer and director.  You can follow Liz on Twitter at https://twitter.com/lizctucker and read her Substack newsletter about the podcast at https://liztucker.substack.com

If you would like to support this podcast you can do so via Patreon at https://www.patreon.com/WhatYourGPDoesntTellYou or via PayPal at https://www.whatyourgpdoesnttellyou.com/support/

What Your GP Doesn’t Tell You has been selected by Feedspot as one of the top 15 UK Medical Podcasts https://blog.feedspot.com/uk_medical_podcasts/

Investigative journalist Charles Piller explains the remarkable story of fraud he has uncovered in Alzheimer’s Disease research, which he discusses in a new book: Doctored: Fraud, Arrogance and Tragedy in the Quest to Cure Alzheimer’s. Charles argues the result of this is that Alzheimer’s research and treatment has been set by years - if not decades.

He goes on to discusse the trial data on which several Alzheimer’s drugs, including Aducanumab, Lecanemab and Donanemab, were approved. Charles says the data is unconvincing and  the side effects – including brain swelling and bleeding -  concerning.

Doctored: Fraud, Arrogance and Tragedy in the Quest to Cure Alzheimer’s by Charles Piller is published by Icon Books.

Charles Piller is an investigative journalist who works for the journal Science. His work has also been published in a number of other publications including The New York Times and the Los Angeles Times. Charles has won a number of journalism awards for his work and is also the author of the books Gene Wars and The Fail-Safe Society.

The host of the podcast, Liz Tucker is an award winning medical journalist and former BBC producer and director.  You can follow Liz on Twitter at https://twitter.com/lizctucker and read her Substack newsletter about the podcast at https://liztucker.substack.com

If you would like to support this podcast you can do so via Patreon at https://www.patreon.com/WhatYourGPDoesntTellYou or via PayPal at https://www.whatyourgpdoesnttellyou.com/support/

What Your GP Doesn’t Tell You has been selected by Feedspot as one of the top 15 UK Medical Podcasts https://blog.feedspot.com/uk_medical_podcasts/

Kerry Bone,  a herbalist who has spent 40 years working in the field, joins the podcast to discuss just what the evidence is that certain herbs and spices might benefit our health.

Today we are bombarded with so much confusing information telling us what to eat, when to eat, and often how particular medicinal plants are particularly beneficial to our health.

So, today I hope our conversation gives the opportunity to find out what the latest data suggests.

One area Kerry discusses is pain managment. He explains that research now indicates that the painkiller paracetamol has a poor safety profile (something also discussed in my podcast with NHS pain consultant Dr Deepak Ravindran) and is not very effective, so reveals we thinks we should also be looking more at herbal alternatives such as curcumin and Boswellia. 

And Kerry reveals the herbs and spices that he takes every day.

Kerry Bone is the  Principal of the Australian College of Phytotherapy. He also founded the Masters of Health Science (Herbal Medicine) course at the University of New England in 2004, and served there as Associate Professor from 2004 to 2012. He is co-author of more than 40 scientific papers on herbal research, and currently serves on the editorial board of the journal Phytomedicine. In addition, he has written a number of textbooks on herbal medicine and is also a co-founder of the company Mediherb.

The host of the podcast, Liz Tucker is an award winning medical journalist and former BBC producer and director.  You can follow Liz on Twitter at https://twitter.com/lizctucker and read her Substack newsletter about the podcast at https://liztucker.substack.com

If you would like to support this podcast you can do so via Patreon at https://www.patreon.com/WhatYourGPDoesntTellYou or via PayPal at https://www.whatyourgpdoesnttellyou.com/support/

What Your GP Doesn’t Tell You has been selected by Feedspot as one of the top 15 UK Medical Podcasts https://blog.feedspot.com/uk_medical_podcasts/

Obstetrician and gynaecologist, Dr Adam Urato, explains why he is concerned about the huge increase in medications now taken by pregnant women. A figure that has surged in the last few decades. Across the world, women are taking more drugs than ever before while pregnant. In the US, around 90% of women expecting a baby will now take some kind of medication during pregnancy

Adam argues the notion a drug is safe until proved otherwise goes completely against the precautionary principle and common sense.

He was one of the first doctors to highlight the risks of a synthetic hormone called Makena, which was supposed to reduce the risk of preterm birth. It was on the market for two decades, even when the evidence showed it didn’t work, it took a further four years to get it withdrawn.

Today Adam is particularly concerned about the number of women taking selective serotonin reuptake inhibitors - or SSRIs for short -  in pregnancy and doesn’t believe they are usually fully informed about the risk.

Yet studies have shown that the medications can increase the likelihood of miscarriage, birth defects, an early birth, a low birth weight and postpartum haemorrhage. In some cases, there also appears to be a potential impact on the baby after birth.

Dr Adam Urato is a board certified obstetrician and gynaecologist, who trained at Harvard Medical School and  who practices in Massachusetts in the US. He has a particular interest in the risks and benefits of medications during pregnancy and has written a number of peer-reviewed papers on the topic.

The host of the podcast, Liz Tucker is an award winning medical journalist and former BBC producer and director.  You can follow Liz on Twitter at https://twitter.com/lizctucker and read her Substack newsletter about the podcast at https://liztucker.substack.com

If you would like to support this podcast you can do so via Patreon at https://www.patreon.com/WhatYourGPDoesntTellYou or via PayPal at https://www.whatyourgpdoesnttellyou.com/support/

What Your GP Doesn’t Tell You has been selected by Feedspot as one of the top 15 UK Medical Podcasts https://blog.feedspot.com/uk_medical_podcasts/

NHS consultant neurologist Dr Suzanne O’Sullivan argues that a range of medical conditions from autism to ADHD are now overdiagnosed, which is completely redefining how we think about sickness and disease. In a new book The Age of Diagnosis; Sickness, Health and Why Medicine Has Gone Too Far, she explains why she believes that creating large numbers of new diagnoses, carries risks for both our mental and physical wellbeing and can turn healthy people into patients.

Suzanne is convinced that we should be cautious about having unnecessary medical tests and investigations that may cause more harm than good.

And she reveals, perhaps surprisingly, that apart from a small benefit for large bowel cancer, cancer screening has not been shown to have an impact on all cause mortality. Suggesting that although we may be finding cancer earlier, we are not necessarily saving lives.

The Age of Diagnosis; Sickness, Health and Why Medicine Has Gone Too Far by Suzanne O'Sullivan is published by Hodder.

The host of the podcast, Liz Tucker is an award winning medical journalist and former BBC producer and director.  You can follow Liz on Twitter at https://twitter.com/lizctucker and read her Substack newsletter about the podcast at https://liztucker.substack.com

If you would like to support this podcast you can do so via Patreon at https://www.patreon.com/WhatYourGPDoesntTellYou or via PayPal at https://www.whatyourgpdoesnttellyou.com/support/

What Your GP Doesn’t Tell You has been selected by Feedspot as one of the top 15 UK Medical Podcasts https://blog.feedspot.com/uk_medical_podcasts/

Dr Bill Harris discusses the critical impact the Omega 3 fatty acids have - not just on our heart health - but on a myriad of other medical conditions.

Bill was one of the earliest researchers in this field. Ever since he gave a fascinating presentation at the Integrative and Personalised Medical Congress in London last year, I’ve been really keen to get him on the podcast.

In our conversation, Bill stresses why he believes the UK NHS's advice on limiting our oily fish intake is inaccurate and badly out-of-date. He reveals why getting enough Omega 3 is crucial.

And in what will be a surprise to many, Bill explains that he doesn’t believe seed oils are problematic and why it is important we also get enough omega 6, which these oils contain.

The host of the podcast, Liz Tucker is an award winning medical journalist and former BBC producer and director.  You can follow Liz on Twitter at https://twitter.com/lizctucker and read her Substack newsletter about the podcast at https://liztucker.substack.com

If you would like to support this podcast you can do so via Patreon at https://www.patreon.com/WhatYourGPDoesntTellYou or via PayPal at https://www.whatyourgpdoesnttellyou.com/support/

What Your GP Doesn’t Tell You has been selected by Feedspot as one of the top 15 UK Medical Podcasts https://blog.feedspot.com/uk_medical_podcasts/

In the very first episode of the new season of What Your GP Doesn't Tell you, Liz Tucker talks to medical doctor and researcher, Dr William Li who has treated some of the toughest cancer cases imaginable.

He argues for the 21st century treatment of cancer, the solution lies not in a single silver bullet but in an integrative approach. In addition to traditional cancer therapies this also includes newer ones such as immunotherapy and takes into account factors such as the gut biome.

Published research now suggests that the health of someone’s gut biome and the particular species of bacteria it contains can make a genuine difference in their body’s ability to fight cancer. William believes it’s essential doctors use all the tools at their disposal to provide the most effective treatment possible.

In a number of patients, including his own mother who faced a stage 4 cancer diagnosis. Using a multi-factorial methodology, William has been able to successfully treating cancer cases which initially appeared to have extremely bleak diagnoses.

The host of the podcast, Liz Tucker is an award winning medical journalist and former BBC producer and director.  You can follow Liz on Twitter at https://twitter.com/lizctucker and read her Substack newsletter about the podcast at https://liztucker.substack.com

If you would like to support this podcast you can do so via Patreon at https://www.patreon.com/WhatYourGPDoesntTellYou or via PayPal at https://www.whatyourgpdoesnttellyou.com/support/

What Your GP Doesn’t Tell You has been selected by Feedspot as one of the top 15 UK Medical Podcasts https://blog.feedspot.com/uk_medical_podcasts/

GP Dr Safia Debar discusses how we can leverage emerging knowledge of neuroscience to help us more effectively manage our stress.

This is something, she has personal knowledge of after finding herself burnt out as a GP, when she turned to her first degree in neuroscience to see how it could help her rethink her approach.

Safia argues it is not so much the stress that we face, but how we think about that stress and the processes that we put in place to manage it.

It is now implicated in almost every disease you can think of and intriguing new research suggests that using meditation as a calming technique, doesn't just affect the mind, but can create genuine biological change, switching our genes on and off.

The host of this award nominated podcast, Liz Tucker is an award winning medical journalist and former BBC producer and director.  You can follow Liz on Twitter at https://twitter.com/lizctucker and read her Substack newsletter about the podcast at https://liztucker.substack.com

If you would like to support this podcast you can do so via Patreon at https://www.patreon.com/WhatYourGPDoesntTellYou or via PayPal at https://www.whatyourgpdoesnttellyou.com/support/

What Your GP Doesn’t Tell You has been selected by Feedspot as one of the top 15 UK Medical Podcasts https://blog.feedspot.com/uk_medical_podcasts/

Psychiatrist Professor Joanna Moncrieff discusses her new book Chemical Imbalance: The Making and the Unmaking of the Serotonin Myth.

I first spoke to Joanna two years ago, just after she had published a review paper suggesting that there was no link between depression and an imbalance of serotonin in the brain.

And her book picks up what happened next. As her article gained more and more attention, she found herself in a political maelstrom facing vitriolic personal and professional criticism.

Because if the serotonin hypothesis was false, what could be the possible grounds for prescribing the popular antidepressants - the selective serotonin uptake inhibitors - better known as the SSRIs?  It’s been claimed in the past they can alter brain chemistry and correct imbalances, but how can they work if Joanna is right and no imbalance exists?

What followed illustrates the fierce political divide in psychiatry between those who remain sceptical of her claims and believe that the current medication for depression is a vital tool and those such as Joanna who are unconvinced by its value.

And we also discuss why much to her surprise, Joanna – although she has always been a socialist -  found far more sympathy for her research from right wing media sources rather than the left.

Chemical Imbalance: The Making and the Unmaking of the Serontonin Myth by Joanna Moncrieff is published by Flint Books.

The host of this award nominated podcast, Liz Tucker is an award winning medical journalist and former BBC producer and director.  You can follow Liz on Twitter at https://twitter.com/lizctucker and read her Substack newsletter about the podcast at https://liztucker.substack.com

If you would like to support this podcast you can do so via Patreon at https://www.patreon.com/WhatYourGPDoesntTellYou or via PayPal at https://www.whatyourgpdoesnttellyou.com/support/

What Your GP Doesn’t Tell You has been selected by Feedspot as one of the top 15 UK Medical Podcasts https://blog.feedspot.com/uk_medical_podcasts/