LessWrong (30+ Karma)

“When is it important that open-weight models aren’t released? My thoughts on the benefits and dangers of open-weight models in response to developments in CBRN capabilities.” by ryan_greenblatt


Listen Later

Recently, Anthropic released Opus 4 and said they couldn't rule out the model triggering ASL-3 safeguards due to the model's CBRN capabilities. That is, they say they couldn't rule out that this model had "the ability to significantly help individuals or groups with basic technical backgrounds (e.g., undergraduate STEM degrees) create/obtain and deploy CBRN weapons" (quoting from Anthropic's RSP). More specifically, Anthropic is worried about the model's capabilities in assisting with bioweapons. (See footnote 3 here.)

Given this and results on Virology Capabilities Test, it seems pretty likely that various other AI companies have or will soon have models which can significantly help amateurs make bioweapons.[1] One relevant question is whether it would be bad if there were open-weight models above this capability threshold. Further, should people advocate for not releasing open-weight models above this capability level?

In this post, I'll discuss how I think about releasing [...]

---

Outline:

(02:45) Costs and benefits of open-weight models with these CBRN capabilities

(08:12) Implications of this cost-benefit situation

(11:39) When would my views on open weights change?

(14:32) Mitigations

The original text contained 10 footnotes which were omitted from this narration.

---

First published:

June 9th, 2025

Source:

https://www.lesswrong.com/posts/TeF8Az2EiWenR9APF/when-is-it-important-that-open-weight-models-aren-t-released

---

Narrated by TYPE III AUDIO.

...more
View all episodesView all episodes
Download on the App Store

LessWrong (30+ Karma)By LessWrong


More shows like LessWrong (30+ Karma)

View all
Making Sense with Sam Harris by Sam Harris

Making Sense with Sam Harris

26,469 Listeners

Conversations with Tyler by Mercatus Center at George Mason University

Conversations with Tyler

2,395 Listeners

The Peter Attia Drive by Peter Attia, MD

The Peter Attia Drive

7,953 Listeners

Sean Carroll's Mindscape: Science, Society, Philosophy, Culture, Arts, and Ideas by Sean Carroll | Wondery

Sean Carroll's Mindscape: Science, Society, Philosophy, Culture, Arts, and Ideas

4,142 Listeners

ManifoldOne by Steve Hsu

ManifoldOne

89 Listeners

Your Undivided Attention by Tristan Harris and Aza Raskin, The Center for Humane Technology

Your Undivided Attention

1,472 Listeners

All-In with Chamath, Jason, Sacks & Friedberg by All-In Podcast, LLC

All-In with Chamath, Jason, Sacks & Friedberg

9,207 Listeners

Machine Learning Street Talk (MLST) by Machine Learning Street Talk (MLST)

Machine Learning Street Talk (MLST)

88 Listeners

Dwarkesh Podcast by Dwarkesh Patel

Dwarkesh Podcast

426 Listeners

Hard Fork by The New York Times

Hard Fork

5,461 Listeners

The Ezra Klein Show by New York Times Opinion

The Ezra Klein Show

15,321 Listeners

Moonshots with Peter Diamandis by PHD Ventures

Moonshots with Peter Diamandis

482 Listeners

No Priors: Artificial Intelligence | Technology | Startups by Conviction

No Priors: Artificial Intelligence | Technology | Startups

121 Listeners

Latent Space: The AI Engineer Podcast by swyx + Alessio

Latent Space: The AI Engineer Podcast

75 Listeners

BG2Pod with Brad Gerstner and Bill Gurley by BG2Pod

BG2Pod with Brad Gerstner and Bill Gurley

461 Listeners