The weight loss world has been turned upside down. With GLP-1 medications like Ozempic and Wegovy delivering unprecedented results, many people are asking: Do we still need to worry about diet and exercise? Can these powerful drugs really do all the heavy lifting, or are we missing something crucial?

This question isn't just academic - it's personal for millions of people who are either on these medications or considering them. The stakes are high: get it wrong, and you could be setting yourself up for weight regain, muscle loss, or missing out on the full benefits these breakthrough treatments can offer.

Join Holly and Jim as they tackle this game-changing question with one of the world's leading obesity researchers. Dr. Thomas Wadden brings decades of experience combining behavioral and pharmaceutical interventions, and his insights will reshape how you think about weight loss in the modern era. You'll discover why the "old rules" still matter - just not in the way you might expect.

Discussed on the episode:

• The shift in how patients experience food and hunger on GLP-1 medications
• Why counting calories may no longer be necessary, but protein intake is more critical than ever
• The muscle loss problem that most people don't see coming (and what to do about it)
• How to safely transition off medications if you choose to - without the inevitable weight regain
• Why food noise feels even louder when it returns and what this means for your strategy
• The shame and stigma still surrounding weight loss medications (and how to overcome it)
• What primary care doctors need to know but often don't when prescribing these drugs
• The role for registered dietitians in the GLP-1 era - and why they're needed more than ever
• Lessons from the National Weight Control Registry that apply to medication users
• The truth about whether exercise becomes easier after weight loss