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We finally have the first-ever FDA-approved oral GLP-1 for treating obesity, and it's a much bigger deal than the headlines suggest…
In this episode, I'm joined by Joseph Zucchi, PA, a clinical supervisor at a weight management clinic who lives and breathes the data behind obesity care. We break down oral Wegovy in practical terms: the real weight loss data, how it compares with weekly injections, why it’s different from Rybelsus, and who it’s best suited for. We also cover cost, insurance disruptions, and what to realistically expect if you’re considering a switch.
If you’re trying to make sense of your options in a fast-changing landscape, whether due to coverage changes, injection concerns, or simple confusion — this conversation helps break it all down using real data.
References
Connect with Joseph Zucchi, PA
Transition Medic Medical Weight Loss
Linkedin
Audio Stamps
01:42 – Meet Joseph Zucchi, PA, clinical supervisor at a comprehensive weight management clinic with an on-site food store.
04:35 – What is oral Wegovy and how does it compare to injectable semaglutide in terms of efficacy and weight loss?
07:21 – The reformulation that makes oral Wegovy different from Rybelsus and why absorption matters.
10:22 – How to take oral Wegovy correctly: timing, dosing instructions, and common mistakes to avoid.
12:02 – Who should consider oral Wegovy and who might be better off sticking with injections?
13:45 – Side effects, dosing transitions, and what to expect when switching from injectable to oral.
22:03 – The importance of specialized care: why working with a weight management expert improves outcomes.
24:00 – Pricing, insurance coverage challenges, and accessibility of oral Wegovy in 2026.
All of the information on this podcast is for general informational purposes only. Please talk to your physician and medical team about what is right for you. No medical advice is being on this podcast.
If you live in Indiana or Illinois and want to work with doctor Matthea Rentea, you can find out more on www.RenteaClinic.com
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