This week on Fat Science, Dr. Emily Cooper, Andrea Taylor, and Mark Wright dive into the world of blood fats—unpacking what cholesterol numbers really mean for your health. They break down HDL (the “good” cholesterol), LDL (the “bad” cholesterol), triglycerides, and spotlight the often-overlooked lipoprotein(a), a genetic risk marker with significant consequences for heart health. The team dispels myths about fats in our diet, covers the impact of lifestyle and genetics, and explores how advanced testing can reveal hidden risks. You’ll come away understanding which fats matter most, why particle size counts, and what actions can help manage your numbers and protect your heart.

Key Takeaways:

• Blood fats, specifically HDL, LDL, and triglycerides, are critical indicators of cardiovascular risk. Advanced testing can identify dangerous subtypes and genetic markers like lipoprotein(a) that standard panels miss.
• HDL has benefits, but high numbers don’t cancel out high LDL; LDL particle size and count are crucial—small, dense particles are more harmful.
• Lipoprotein(a) is a major genetic risk factor for heart disease and stroke that isn’t modifiable by diet or exercise; new treatments are in development.
• Plant-based monounsaturated fats (like olive oil and avocados), resistant starches, and soluble fiber offer metabolic and heart-health benefits, but even perfect diets may not lower genetic cholesterol risks.
• Lifestyle factors—exercise, avoiding smoking, quality sleep, and managing conditions like diabetes—are critical for reducing cardiovascular risk, especially if you have inherited risk markers.
• Heart health isn’t just about body size—“looking healthy” doesn’t guarantee healthy arteries; everyone should know their numbers and consider advanced heart scans as needed.

Resources:

• Connect with Dr. Emily Cooper on LinkedIn.
• Connect with Mark Wright on LinkedIn.
• Connect with Andrea Taylor on Instagram.

Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.

If you have a question for Dr. Cooper, send an email to [email protected]. If you have a show idea, feedback, or just want to connect, you can also reach us us at [email protected].

Fat Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/

Diabetes Wake-Up Call: The Silent Epidemic

In this episode of Fat Science, Dr. Emily Cooper, Andrea Taylor and Mark Wright take on a troubling statistic—half of American adults are either diabetic or prediabetic, and for those with prediabetes, 8 in 10 don’t know it. Think about your own family. The odds are one in two of your loved ones are at risk.

The good news is diagnosing diabetes is easy, and in many cases it’s reversible. Dr. Cooper breaks down the tests you should get, the numbers to look for and the top treatments. Taking control of your diabetes risk just could save your life. 

Key Takeaways:

• Diabetes affects nearly half of the U.S. population, with approximately 80% of prediabetes cases undiagnosed.
• Type 1 diabetes requires lifelong insulin therapy, while type 2 is often linked to genetic predisposition and lifestyle, with potential for reversal.
• Regular screening for glucose (blood sugar) and HbA1c levels (your long-term blood sugar average) is crucial for early detection of prediabetes and diabetes, applicable to both adults and children from age 10.
• Managing diabetes involves a comprehensive approach, including diet, exercise, lifestyle modifications, and medications like metformin and GLP1’s.
• Medications are not a failure but a crucial tool in preventing severe complications and maintaining a high quality of life.

Resources:

• Connect with Dr. Emily Cooper on LinkedIn.
• Connect with Mark Wright on LinkedIn.
• Connect with Andrea Taylor on Instagram.

Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.

If you have a question for Dr. Cooper, send an email to [email protected]. If you have a show idea, feedback, or just want to connect, you can also reach us us at [email protected].

In this episode of Fat Science, Dr. Emily Cooper, Andrea Taylor and Mark Wright continue exploring the top ten positive things you can do for your metabolism, focusing on steps five through one. With an honest and approachable discussion, this episode sheds light on essential topics like endocrine disruptors, nutrition, sleep, body image, and why the focus should be on health, not weight. Get practical advice for positive changes you can implement in your daily life.

Key Takeaways:

Endocrine Disruptors – Learn about EDCs and MDCs, their widespread presence, and steps to minimize exposure for better metabolic health.

Nutrition for Health, Not Weight Loss – Shift your focus to fueling your body and maintaining a positive relationship with food, emphasizing nutrition over diet restrictions.

Sleep and Sleep Apnea – Understand the critical role of sleep in metabolism, and consider sleep apnea testing to improve metabolic function and overall well-being.

Body Image – Address the influence of societal pressures and focus on positive self-image to support metabolic health, being mindful of language around children.

Focus on Health, Not Weight – Highlight the importance of prioritizing health metrics over weight, and recognize the limitations of using BMI as a sole indicator of health.

Resources:

• Connect with Dr. Emily Cooper on LinkedIn.
• Connect with Mark Wright on LinkedIn.
• Connect with Andrea Taylor on Instagram.

Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.

If you have a question for Dr. Cooper, send an email to [email protected]. If you have a show idea, feedback, or just want to connect, you can also reach us us at [email protected].

Fat Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/

n this episode of Fat Science, Dr. Emily Cooper, Andrea Taylor and Mark Wright break down their top ten lifestyle strategies to enhance your metabolic health. They critically discuss powerful yet straightforward approaches that can significantly improve metabolism. The focus is on easy-to-implement, applicable tips, from knowing key health numbers to managing stress effectively.

Key Takeaways:

• Know Your Numbers: Understanding baseline health metrics like blood pressure, glucose, and cholesterol is crucial for assessing risk and taking proactive steps toward better health. Dr. Cooper breaks down the key metrics you should ask your doctor about.
• Physical Activity: Integrate enjoyable and consistent physical activities into your daily routine to strengthen bones, muscles, and cardiovascular health.
• Stress Management: Be aware of the impact stress can have on metabolism and explore ways to address stress in life, including therapy, meditation, and lifestyle changes.
• Gut Health: Maintain a varied diet rich in probiotics and prebiotic foods to support a healthy microbiome and overall well-being.
• Substances: Avoid substance overuse including alcohol and nicotine, which can negatively impact metabolic health.

Resources:

• Connect with Dr. Emily Cooper on LinkedIn.
• Connect with Mark Wright on LinkedIn.
• Connect with Andrea Taylor on Instagram.

Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.

If you have a question for Dr. Cooper, send an email to [email protected]. If you have a show idea, feedback, or just want to connect, you can also reach us us at [email protected].

Fat Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/

In this episode of Fat Science, Dr. Emily Cooper, Andrea Taylor and Mark Wright explore the human connections in metabolic medicine. With special guest Alisha, a nurse practitioner at the Cooper Center for Metabolism, the episode delves into how patient-provider relationships have a profound impact on metabolic health outcomes. 

If you're interested in how the world of metabolic medicine is evolving and want a human-centered perspective, this episode is a must-listen. You’ll walk away with a better understanding of how interconnected our body’s health systems are and why personalized care matters.

Key Takeaways:

• Alisha’s Journey: Discover how Alisha transitioned from the ICU to preventive care in metabolic medicine, driven by her desire to prevent end-stage diseases she witnessed firsthand.
• Breaking Myths: The episode sheds light on why counting calories isn't the answer and how metabolic dysfunction is not just a collection of isolated symptoms but a comprehensive system affecting overall health.
• Preventive Mindset: Learn from Dr. Cooper and Alisha as they discuss the importance of early intervention, preventive care, and how understanding your body’s metabolic signals today can avert future health issues.
• Finding the Right Help: Looking for an expert in obesity medicine? Click the following link to find a board-certified specialist in your area: https://abom.learningbuilder.com/public/membersearch

Resources:

• Connect with Dr. Emily Cooper on LinkedIn.
• Connect with Mark Wright on LinkedIn.
• Connect with Andrea Taylor on Instagram.

Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.

If you have a question for Dr. Cooper, send an email to [email protected].  If you have a show idea, feedback, or just want to connect, you can also reach us us at [email protected].

Fat Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/

On this episode of Fat Science, it’s time to hear from some of you, our listeners. Dr. Emily Cooper, Andrea Taylor and Mark Wright are joined by two loyal listeners, Scott and Heidi. The episode explores personal anecdotes and transformative moments thanks to a deeper understanding of metabolic health and its broader implications. It also shows you don’t have to have Metabolic Syndrome to benefit from understanding the science connected to it.

Key Takeaways:

• Weight control and diets have long been struggles, but a scientific understanding of metabolism can demystify these challenges.
• Addressing familial and individual metabolic issues requires comprehensive evaluation beyond lifestyle adjustments.
• Sleep quality profoundly affects metabolic rates, highlighting the interplay between hormones like ghrelin and leptin.

Personal Stories & Practical Advice:

• Scott finds resonance with the podcast through its unpacking of metabolism beyond diet culture, while Heidi recognizes the alleviation of stress and restriction, changing family health dynamics.
• Dr. Cooper pushes for awareness of underlying medical issues over lifestyle blame, advocating for thorough evaluations.

Resources:

• Connect with Dr. Emily Cooper on LinkedIn.
• Connect with Mark Wright on LinkedIn.
• Connect with Andrea Taylor on Instagram.

Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.

If you have a question for Dr. Cooper, send an email to [email protected].  If you have a show idea, feedback, or just want to connect, you can also reach us us at [email protected].

Fat Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/

On this episode of Fat Science, Dr. Emily Cooper, Andrea Taylor and Mark Wright delve deeper into the topic of compounded metabolic drugs. 

Dr. Cooper addresses criticisms from listeners about the previous discussion and provides insights into the economic reasons driving people towards compounded drugs. She also dissects the ethics and economics of the diet industry transforming into a subscription medicine model and the role of insurance in accessibility to metabolic treatments.

Key Takeaways:

• Compounded drugs often act as a misleading alternative to brand medications, lacking FDA approval and potentially jeopardizing health outcomes.
• Employers significantly influence weight-related treatment coverage, and advocacy for coverage changes can be a crucial step towards accessible medications.
• Insurance restrictions and economic barriers force many to explore compounded drugs despite potential risks.
• The rise of online subscription models parallels the diet industry’s modus operandi of exploiting vulnerable demographics for profit.
• Greater transparency and regulation within the pharmaceutical and insurance sectors are needed to ensure safe and equitable access to treatments.

Personal Stories & Practical Advice:

• Andrea reflects on her decision to prioritize health despite the significant cost by sourcing medications through Canada rather than risking compounded drugs.
• Discussions emphasize the importance of a comprehensive and guided medical approach, advocating for patient education and active engagement with healthcare providers.

Important Update: Changes in GLP-1 Medication Availability and Compounding Regulations

This episode was recorded before recent regulatory developments regarding GLP-1 medications. As of our current information:

The FDA has determined that shortages have been resolved for all formulations of tirzepatide (marketed as Mounjaro and Zepbound) and semaglutide (marketed as Rybelsus, Ozempic, and Wegovy). Consequently, compounding these medications is no longer legally permitted under FDA regulations.

Additionally, Novo Nordisk has expanded its patient assistance program by implementing enhanced coupon discounts across all Wegovy dosage strengths to improve affordability and access to match Lilly's efforts for Mounjaro and Zepbound access.

Please note that regulatory policies and manufacturer programs regarding these medications continue to evolve. For the most up-to-date information, we recommend consulting current FDA announcements and manufacturer websites.

Resources:

• Connect with Dr. Emily Cooper on LinkedIn.
• Connect with Mark Wright on LinkedIn.
• Connect with Andrea Taylor on Instagram.

Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.

If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at [email protected].

Fat Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/

On this episode of Fat Science, Dr. Emily Cooper, Andrea Taylor and Mark Wright open the mailbag and answer questions from listeners all over the world.

Dr. Cooper provides expert insights into complex questions about metabolic health, covering topics including metabolic dysfunction, the effects of chemotherapy on metabolism, a discussion of GLP-1s and those trying to get pregnant and the role of iodine in the diet. 

Engaging and informative, this episode also arms you with the vocabulary and understanding needed to discuss metabolism with your healthcare provider.

Key Takeaways:

• Metabolic medications like GLP-1s are not just for weight loss; they target the metabolic system, improving fertility and metabolic health.
• The jury is still out as to whether taking GLP-1s are safe for those trying to become pregnant, but management is possible knowing the half-life of the various GLP-1 drugs.
• Chemotherapy can impact metabolism; a comprehensive metabolic assessment post-treatment is essential for recovery.
• Iodine is crucial for thyroid function, and deficiencies may arise from using non-iodized salts; checking iodine levels can guide supplementation.
• Managing mindset and mechanical eating is essential when using metabolic medications to avoid calorie-counting traps.

Personal Stories & Practical Advice:

• Andrea shares her journey of freeing herself from calorie counting and embracing a healthier mindset.
• Listeners' questions reflect global engagement and common challenges faced in managing metabolic health.

Resources:

• Connect with Dr. Emily Cooper on LinkedIn.
• Connect with Mark Wright on LinkedIn.
• Connect with Andrea Taylor on Instagram.

Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.

If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at [email protected].

Fat Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/

On this episode of Fat Science, Dr. Emily Cooper, Andrea Taylor and Mark Wright explore the intricate metabolic ties to Polycystic Ovarian Syndrome (PCOS). Dr. Cooper provides expert insight into how understanding these links can transform what seems like a permanent condition into a reversible one. 

“ I feel like there's so much despair around PCOS when it actually doesn't have to be a long-term condition,” says Dr. Cooper. “I know some of that desperation comes from the infertility piece of it… so it's really important to calm down the (metabolic) dysfunction to be successful in fertility.”

Key Takeaways:

• PCOS is often misunderstood as solely an ovarian issue, but it is deeply rooted in neuroendocrine and metabolic imbalances.
• Diagnosing PCOS involves analyzing menstrual irregularities, androgen levels, and related physical symptoms like hirsutism and acne.
• Traditional treatments include metformin and spironolactone, but focusing on overall metabolic health can lead to reversal of PCOS symptoms.
• The importance of comprehensive metabolic health, including regular fueling, sleep quality, and potentially targeting specific metabolic pathways, is emphasized.
• Misguided advice to lose weight often exacerbates PCOS; instead, enhancing metabolic signals offers a sustainable solution.

Resources:

• Connect with Dr. Emily Cooper on LinkedIn.
• Connect with Mark Wright on LinkedIn.
• Connect with Andrea Taylor on Instagram.

Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.

If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at [email protected].

Fat Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/

On this episode of Fat Science, it’s time to let go of the old paradigm “calories in, calories out.” Join hosts Dr. Emily Cooper, Andrea Taylor and Mark Wright as they kick CICO to the curb. 

The idea that a person’s weight is determined only by the ratio of calories consumed and calories burned is an over-simplification and often not true, especially for people with metabolic dysfunction. 

Dr. Cooper reveals the real key to weight management is not calorie counting but understanding metabolic function influenced by the  neuroendocrine system. Through personal stories and insights, they explore why diets don’t work and how acknowledging the complexity of metabolism can lead to better health.

Key Takeaways:

• Caloric intake does not have a static burn rate; it's controlled by dynamic neuroendocrine signals.
• Metabolic adaptations occur with calorie restriction, reducing metabolic rate, making weight loss unsustainable over the long term.
• The science holds answers to metabolic dysfunction, revealed by metabolic testing and hormone imbalance recognition.
• Education and communication can challenge and change the stigma and bias around weight, leading to a more informed society.

Personal Stories & Practical Advice:

• Andrea shares her journey about ignoring diets and focusing on metabolic health for long-term benefits.
• Dr. Cooper recounts her challenges in communicating her findings in a positive way, leading to greater acceptance and understanding among patients, healthcare providers and the general public.

Resources:

• Connect with Dr. Emily Cooper on LinkedIn.
• Connect with Mark Wright on LinkedIn.
• Connect with Andrea Taylor on Instagram.

Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.

If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at [email protected].

Fat Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/