Join Dr. Emily Cooper, Andrea Taylor, and Mark Wright on Fat Science as they unpack the complexities of dosing GLP-1 medications for metabolic health and weight management. Dr. Cooper emphasizes the importance of an individualized approach, debunking the myth that higher doses or faster titration always lead to better outcomes. 

The team addresses listener questions about how and when to increase doses, highlight the risks of rapid escalation, and discuss the nuanced ways these drugs impact metabolic health beyond just weight loss. Real-life experiences and thoughtful, science-backed guidance will help you navigate your own journey with metabolic dysfunction and medication.

Key Takeaways:

• Dosing of GLP-1 medications should always be tailored to the individual, considering response, side effects, and other health factors—not just the speed of weight loss.
• Starting at the lowest dose and titrating slowly increases medication tolerance and long-term effectiveness.
• Lab markers such as A1C, glucose, cholesterol, and muscle mass are key indicators in determining if the medication and dosing are "working."
• Rapidly escalating to the highest dose can backfire, causing side effects and limiting future treatment options.
• Dieting mindsets and using medication solely as an appetite suppressant can lead to loss of lean mass and suboptimal health outcomes.
• Ongoing patient-provider relationships and regular lab work ensure medication strategies remain safe and effective.

Personal Stories & Practical Advice:

• Andrea reflects on her initial desire for quick fixes and shares lessons learned about patience, nourishment, and long-term progress. 
• Mark discusses insurance-driven medication switches and finding the “sweet spot” for dosing with Dr. Cooper’s guidance.

Resources:

• Connect with Dr. Emily Cooper on LinkedIn.
• Connect with Mark Wright on LinkedIn.
• Connect with Andrea Taylor on Instagram.

Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.

If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at [email protected] or [email protected].

Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/

Join Dr. Emily Cooper, Andrea Taylor, and Mark Wright on Fat Science for a special mailbag episode answering listener questions about metabolic health. Dr. Cooper explains the difference between mindful and mechanical (timed) eating, especially for those using medications like Zepbound. 

The team also addresses emotional challenges tied to frequent eating, societal fat shaming, and the complexities of medication side effects for those on GLP-1 agonists and antipsychotics. Real experiences and practical advice help shed light on fueling your body, breaking free from diet culture guilt, and navigating complex emotions on the journey to better health.

Key Takeaways:

• GLP-1 medications like Zepbound affect appetite and metabolism but can also suppress hunger cues; mechanical eating—timing meals and including all food groups—prevents nutritional deficits and supports long-term metabolic health.
• Eating too few calories, even when appetite is low, can be detrimental; mechanical eating helps maintain muscle mass and prevent stalled metabolism.
• Emotional barriers, guilt, and anxiety around food are common due to fat shaming and past dieting experiences. Meal planning and support from dietitians can help ease this transition.
• GLP-1s may alter medication absorption or trigger anxiety episodes due to blood sugar fluctuations; monitoring and professional advice are recommended when combining with psych meds.

Personal Stories & Practical Advice:

• Andrea shares strategies for getting enough nutrition when appetite is low, her experiences with fat shaming, and her approach to enjoying food without guilt.
• Mark and Dr. Cooper discuss breaking free from restrictive food mindsets and building a positive, fuel-focused relationship with eating.

Key Takeaways:

Resources:

• Connect with Dr. Emily Cooper on LinkedIn.
• Connect with Mark Wright on LinkedIn.
• Connect with Andrea Taylor on Instagram.

Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.

If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at [email protected] or [email protected].

Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/

This week on Fat Science, Dr. Emily Cooper, Andrea Taylor and Mark Wright tackle the urgent issue of deep funding cuts to scientific research in the United States. Dr. Cooper shares firsthand insight on how these changes are affecting patient care and scientific integrity, highlighting the pressures researchers face—including censorship and loss of resources at institutions like the NIH. 

The conversation sheds light on how misinformation, government interference, and reduced diversity in studies threaten the future of metabolic, cancer and public health research. Listeners will better understand why research matters for everyday health, and what’s at stake when critical projects lose funding.

Key Takeaways:

• Sweeping research cuts at major institutions like NIH jeopardize progress in areas like metabolic health, cancer, ALS, heart disease, and Alzheimer’s.
• Researchers are facing censorship and pressure to alter or suppress scientific findings in nutrition, autism, and vaccine research.
• Reducing diversity in research undermines scientific accuracy and inclusivity, risking treatments that don’t address the needs of all populations.
• Slashed funding will stall new medical discoveries, limit future treatment options, and may have consequences for decades to come.
• Misinformation around vaccines and public health is rising as government agencies are pressured to alter or hide true scientific data.

Resources:

Links: 

Current Medical Reporting

Vin Gupta, MD

Nutrition Information

Nutrition for Mortals Podcast with Dietitians: Matt and Jen

Infectious Diseases, Immunizations

Maria Van Kerkhove - WHO

Jeff Duchin

Michael Osterholm, CIDRAP

Kevin Hall Research

Kevin Hall on LinkedIn

• Connect with Dr. Emily Cooper on LinkedIn.
• Connect with Mark Wright on LinkedIn.
• Connect with Andrea Taylor on Instagram.

Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.

If you have a question for Dr. Cooper, send an email to [email protected]. If you have a show idea, feedback, or just want to connect, you can also reach us us at[email protected].

Fat Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/

This week on Fat Science, Dr. Emily Cooper, Andrea Taylor, and Mark Wright dive into the world of blood fats—unpacking what cholesterol numbers really mean for your health. They break down HDL (the “good” cholesterol), LDL (the “bad” cholesterol), triglycerides, and spotlight the often-overlooked lipoprotein(a), a genetic risk marker with significant consequences for heart health. The team dispels myths about fats in our diet, covers the impact of lifestyle and genetics, and explores how advanced testing can reveal hidden risks. You’ll come away understanding which fats matter most, why particle size counts, and what actions can help manage your numbers and protect your heart.

Key Takeaways:

• Blood fats, specifically HDL, LDL, and triglycerides, are critical indicators of cardiovascular risk. Advanced testing can identify dangerous subtypes and genetic markers like lipoprotein(a) that standard panels miss.
• HDL has benefits, but high numbers don’t cancel out high LDL; LDL particle size and count are crucial—small, dense particles are more harmful.
• Lipoprotein(a) is a major genetic risk factor for heart disease and stroke that isn’t modifiable by diet or exercise; new treatments are in development.
• Plant-based monounsaturated fats (like olive oil and avocados), resistant starches, and soluble fiber offer metabolic and heart-health benefits, but even perfect diets may not lower genetic cholesterol risks.
• Lifestyle factors—exercise, avoiding smoking, quality sleep, and managing conditions like diabetes—are critical for reducing cardiovascular risk, especially if you have inherited risk markers.
• Heart health isn’t just about body size—“looking healthy” doesn’t guarantee healthy arteries; everyone should know their numbers and consider advanced heart scans as needed.

Resources:

• Connect with Dr. Emily Cooper on LinkedIn.
• Connect with Mark Wright on LinkedIn.
• Connect with Andrea Taylor on Instagram.

Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.

If you have a question for Dr. Cooper, send an email to [email protected]. If you have a show idea, feedback, or just want to connect, you can also reach us us at [email protected].

Fat Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/

Diabetes Wake-Up Call: The Silent Epidemic

In this episode of Fat Science, Dr. Emily Cooper, Andrea Taylor and Mark Wright take on a troubling statistic—half of American adults are either diabetic or prediabetic, and for those with prediabetes, 8 in 10 don’t know it. Think about your own family. The odds are one in two of your loved ones are at risk.

The good news is diagnosing diabetes is easy, and in many cases it’s reversible. Dr. Cooper breaks down the tests you should get, the numbers to look for and the top treatments. Taking control of your diabetes risk just could save your life. 

Key Takeaways:

• Diabetes affects nearly half of the U.S. population, with approximately 80% of prediabetes cases undiagnosed.
• Type 1 diabetes requires lifelong insulin therapy, while type 2 is often linked to genetic predisposition and lifestyle, with potential for reversal.
• Regular screening for glucose (blood sugar) and HbA1c levels (your long-term blood sugar average) is crucial for early detection of prediabetes and diabetes, applicable to both adults and children from age 10.
• Managing diabetes involves a comprehensive approach, including diet, exercise, lifestyle modifications, and medications like metformin and GLP1’s.
• Medications are not a failure but a crucial tool in preventing severe complications and maintaining a high quality of life.

Resources:

• Connect with Dr. Emily Cooper on LinkedIn.
• Connect with Mark Wright on LinkedIn.
• Connect with Andrea Taylor on Instagram.

Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.

If you have a question for Dr. Cooper, send an email to [email protected]. If you have a show idea, feedback, or just want to connect, you can also reach us us at [email protected].

In this episode of Fat Science, Dr. Emily Cooper, Andrea Taylor and Mark Wright continue exploring the top ten positive things you can do for your metabolism, focusing on steps five through one. With an honest and approachable discussion, this episode sheds light on essential topics like endocrine disruptors, nutrition, sleep, body image, and why the focus should be on health, not weight. Get practical advice for positive changes you can implement in your daily life.

Key Takeaways:

Endocrine Disruptors – Learn about EDCs and MDCs, their widespread presence, and steps to minimize exposure for better metabolic health.

Nutrition for Health, Not Weight Loss – Shift your focus to fueling your body and maintaining a positive relationship with food, emphasizing nutrition over diet restrictions.

Sleep and Sleep Apnea – Understand the critical role of sleep in metabolism, and consider sleep apnea testing to improve metabolic function and overall well-being.

Body Image – Address the influence of societal pressures and focus on positive self-image to support metabolic health, being mindful of language around children.

Focus on Health, Not Weight – Highlight the importance of prioritizing health metrics over weight, and recognize the limitations of using BMI as a sole indicator of health.

Resources:

• Connect with Dr. Emily Cooper on LinkedIn.
• Connect with Mark Wright on LinkedIn.
• Connect with Andrea Taylor on Instagram.

Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.

If you have a question for Dr. Cooper, send an email to [email protected]. If you have a show idea, feedback, or just want to connect, you can also reach us us at [email protected].

Fat Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/

n this episode of Fat Science, Dr. Emily Cooper, Andrea Taylor and Mark Wright break down their top ten lifestyle strategies to enhance your metabolic health. They critically discuss powerful yet straightforward approaches that can significantly improve metabolism. The focus is on easy-to-implement, applicable tips, from knowing key health numbers to managing stress effectively.

Key Takeaways:

• Know Your Numbers: Understanding baseline health metrics like blood pressure, glucose, and cholesterol is crucial for assessing risk and taking proactive steps toward better health. Dr. Cooper breaks down the key metrics you should ask your doctor about.
• Physical Activity: Integrate enjoyable and consistent physical activities into your daily routine to strengthen bones, muscles, and cardiovascular health.
• Stress Management: Be aware of the impact stress can have on metabolism and explore ways to address stress in life, including therapy, meditation, and lifestyle changes.
• Gut Health: Maintain a varied diet rich in probiotics and prebiotic foods to support a healthy microbiome and overall well-being.
• Substances: Avoid substance overuse including alcohol and nicotine, which can negatively impact metabolic health.

Resources:

• Connect with Dr. Emily Cooper on LinkedIn.
• Connect with Mark Wright on LinkedIn.
• Connect with Andrea Taylor on Instagram.

Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.

If you have a question for Dr. Cooper, send an email to [email protected]. If you have a show idea, feedback, or just want to connect, you can also reach us us at [email protected].

Fat Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/

In this episode of Fat Science, Dr. Emily Cooper, Andrea Taylor and Mark Wright explore the human connections in metabolic medicine. With special guest Alisha, a nurse practitioner at the Cooper Center for Metabolism, the episode delves into how patient-provider relationships have a profound impact on metabolic health outcomes. 

If you're interested in how the world of metabolic medicine is evolving and want a human-centered perspective, this episode is a must-listen. You’ll walk away with a better understanding of how interconnected our body’s health systems are and why personalized care matters.

Key Takeaways:

• Alisha’s Journey: Discover how Alisha transitioned from the ICU to preventive care in metabolic medicine, driven by her desire to prevent end-stage diseases she witnessed firsthand.
• Breaking Myths: The episode sheds light on why counting calories isn't the answer and how metabolic dysfunction is not just a collection of isolated symptoms but a comprehensive system affecting overall health.
• Preventive Mindset: Learn from Dr. Cooper and Alisha as they discuss the importance of early intervention, preventive care, and how understanding your body’s metabolic signals today can avert future health issues.
• Finding the Right Help: Looking for an expert in obesity medicine? Click the following link to find a board-certified specialist in your area: https://abom.learningbuilder.com/public/membersearch

Resources:

• Connect with Dr. Emily Cooper on LinkedIn.
• Connect with Mark Wright on LinkedIn.
• Connect with Andrea Taylor on Instagram.

Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.

If you have a question for Dr. Cooper, send an email to [email protected].  If you have a show idea, feedback, or just want to connect, you can also reach us us at [email protected].

Fat Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/

On this episode of Fat Science, it’s time to hear from some of you, our listeners. Dr. Emily Cooper, Andrea Taylor and Mark Wright are joined by two loyal listeners, Scott and Heidi. The episode explores personal anecdotes and transformative moments thanks to a deeper understanding of metabolic health and its broader implications. It also shows you don’t have to have Metabolic Syndrome to benefit from understanding the science connected to it.

Key Takeaways:

• Weight control and diets have long been struggles, but a scientific understanding of metabolism can demystify these challenges.
• Addressing familial and individual metabolic issues requires comprehensive evaluation beyond lifestyle adjustments.
• Sleep quality profoundly affects metabolic rates, highlighting the interplay between hormones like ghrelin and leptin.

Personal Stories & Practical Advice:

• Scott finds resonance with the podcast through its unpacking of metabolism beyond diet culture, while Heidi recognizes the alleviation of stress and restriction, changing family health dynamics.
• Dr. Cooper pushes for awareness of underlying medical issues over lifestyle blame, advocating for thorough evaluations.

Resources:

• Connect with Dr. Emily Cooper on LinkedIn.
• Connect with Mark Wright on LinkedIn.
• Connect with Andrea Taylor on Instagram.

Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.

If you have a question for Dr. Cooper, send an email to [email protected].  If you have a show idea, feedback, or just want to connect, you can also reach us us at [email protected].

Fat Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/

On this episode of Fat Science, Dr. Emily Cooper, Andrea Taylor and Mark Wright delve deeper into the topic of compounded metabolic drugs. 

Dr. Cooper addresses criticisms from listeners about the previous discussion and provides insights into the economic reasons driving people towards compounded drugs. She also dissects the ethics and economics of the diet industry transforming into a subscription medicine model and the role of insurance in accessibility to metabolic treatments.

Key Takeaways:

• Compounded drugs often act as a misleading alternative to brand medications, lacking FDA approval and potentially jeopardizing health outcomes.
• Employers significantly influence weight-related treatment coverage, and advocacy for coverage changes can be a crucial step towards accessible medications.
• Insurance restrictions and economic barriers force many to explore compounded drugs despite potential risks.
• The rise of online subscription models parallels the diet industry’s modus operandi of exploiting vulnerable demographics for profit.
• Greater transparency and regulation within the pharmaceutical and insurance sectors are needed to ensure safe and equitable access to treatments.

Personal Stories & Practical Advice:

• Andrea reflects on her decision to prioritize health despite the significant cost by sourcing medications through Canada rather than risking compounded drugs.
• Discussions emphasize the importance of a comprehensive and guided medical approach, advocating for patient education and active engagement with healthcare providers.

Important Update: Changes in GLP-1 Medication Availability and Compounding Regulations

This episode was recorded before recent regulatory developments regarding GLP-1 medications. As of our current information:

The FDA has determined that shortages have been resolved for all formulations of tirzepatide (marketed as Mounjaro and Zepbound) and semaglutide (marketed as Rybelsus, Ozempic, and Wegovy). Consequently, compounding these medications is no longer legally permitted under FDA regulations.

Additionally, Novo Nordisk has expanded its patient assistance program by implementing enhanced coupon discounts across all Wegovy dosage strengths to improve affordability and access to match Lilly's efforts for Mounjaro and Zepbound access.

Please note that regulatory policies and manufacturer programs regarding these medications continue to evolve. For the most up-to-date information, we recommend consulting current FDA announcements and manufacturer websites.

Resources:

• Connect with Dr. Emily Cooper on LinkedIn.
• Connect with Mark Wright on LinkedIn.
• Connect with Andrea Taylor on Instagram.

Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.

If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at [email protected].

Fat Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/