In this episode of Hypertrophy Past & Present, Jake and Chris begin with a classic Clancy Ross full-body routine from the Silver Era, then move into a discussion about training frequency, mTOR, muscle protein synthesis, and whether training again before the previous hypertrophy stimulus has “finished” is actually a problem.

Key topics include:
• Clancy Ross’ 1940s full-body single set routine
• Whether training a muscle every 48 hours can blunt hypertrophy
• How repeated bout effect studies can be misapplied to training frequency
• Why mTOR signalling is not the same thing as muscle growth
• The role of oxidative stress and inflammation in post-workout recovery
• How volume, frequency, stress, dieting, and athletic workloads affect recovery
• Why the best training frequency is limited by recovery