The intestinal barrier serves as a gatekeeper to the human body. The loss of the health and integrity of this barrier influences multiple aspects of human health – including cardiometabolic function, neurological health, behavior, and more – in surprising and unexpected ways. One of these ways involves lipopolysaccharide, or LPS, a bacterial product that arises in the intestine, and its interaction with far distal tissues and organs via the induction of immune mediators. Dr. Rhonda Patrick was the keynote speaker for the Metabolic Health Summit, held May 5 – 8, 2022, in Santa Barbara, California. Her presentation described the role that intestinal permeability and bacterial products play in aging, inflammation, and chronic disease.

In this episode, we discuss:

• (00:00) Introduction
• (08:12) Atherosclerosis
• (13:49) Brain
• (16:07) Circulating LPS and behavior
• (19:05) Toll-like receptors and inflammation
• (24:00) Factors that affect intestinal permeability
• (30:10) Alcohol
• (32:07) Gluten
• (35:21) Butyrate and dietary fiber
• (37:48) Dietary fat
• (42:21) Biomarkers of intestinal permeability
• (43:11) Omega-3 fatty acids
• (50:02) Q&A

Show notes and video

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