Neurologist and bestselling author Dr. David Perlmutter returns to discuss the groundbreaking science behind his new book, Brain Defenders. Together, we unpack why Alzheimer's disease may be driven less by amyloid plaques and more by chronic inflammation, metabolic dysfunction, and changes in the brain's immune cells.

Dr. Perlmutter explains the critical role of microglia, how blood sugar and insulin resistance affect the brain, why gut health is directly connected to cognitive function, and what lifestyle habits have the strongest evidence for protecting memory as we age.

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Topics Discussed:

→ What causes Alzheimer's disease?

→ How do you prevent Alzheimer'?

→ What foods improve brain health?

→ Can inflammation cause dementia?

→ Does blood sugar affect memory?

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Timestamps: 

→ 00:00:00 - Introduction

→ 00:03:07 - Why Alzheimer's Research Is Changing

→ 00:05:42 - Microglia Explained

→ 00:10:44 - Understanding Immunomatabolism 

→ 00:15:10 - Insulin Resistance + "Type 3 Diabetes"

→ 00:19:27 - Long COVID + Brain Recovery

→ 00:30:20 - Lifestyle Changes For Brain Health 

→ 00:35:22 - The Gut Microbiome

→ 00:37:27 - Tracking Gut Health 

→ 00:39:26 - Early Biomarkers/Testing 

→ 00:45:20 - Exercise + Muscle

→ 00:49:51 - Children’s Nutrition 

→ 00:52:48 - Women’s Dementia Risk  

→ 00:58:53 - GLP1s + Other Peptides  

→ 01:07:41 - Dr. Perlmutter's Daily Brain Health Routine

Further Listening: 

→ Nutrition for a Healthy Brain & Body (Without Counting Calories) | Max Lugavere

Check Out David:

→ Book | Braindefenders.com

→ Website

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