In this interview, Andrea Russo, MD, FACC; Marek Jastrzebski, MD, PhD; and Jeffrey Hsu, MD, PhD, focus on a Heart Rhythm Society late-breaking study on LBB optimized CRT, discussing its differences from traditional pacing and benefits to the patient, limitations of the alternative techniques, and a new method to more fully restore physiology of depolarization of the LV in patients with HF and broad QRS complex. Like what you hear? Get 20 episodes a month with CME/MOC credit at www.acc.org/ACCEL.