Many older patients find it difficult to take many medications, especially if the medication regimens of "polypharmacy" are complicated, but would we ever consider deprescribing life-extending medications? In this interview, Laxmi Mehta MD, FACC; James N. Kirkpatrick, MD, FACC, FASE, Chair of ACC Geriatrics Section; and Payal Kohli MD, FACC, discuss polypharmacy in the geriatric patient. For 20+ insider interviews like these every month with CME/MOC credit, subscribe to ACCEL at www.ACC.org/ACCEL.