New analyses highlight the atrial fibrillation subpopulations with potential to progress to major morbidity outcomes and permit a reevaluation of the benefits of rhythm control for these endpoints and need for early restoration of rhythm control. In this interview, Sanjeev Saksena MBBS, MD, FACC, and Andrea M. Russo MD, FACC, with Arav Jhand, MD, discuss reinterpreting the AFFIRM (Atrial Fibrillation Follow-up Investigation of Rhythm Management) study in 2020.