Dhru Purohit Show

Are You Sabotaging Your Weight Loss Goals? Expert Sheds Light on the Key to Becoming Leaner and Stronger in 2025 with Dr. Mike Israetel


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This episode is brought to you by Bon Charge, One Skin, and Cozy Earth.


Sticking to a healthy diet isn’t always easy, and it can feel almost impossible when you’re just starting out. While some may see this as a sign of weakness, today’s guest explains that our bodies simply haven’t evolved to keep up with modern lifestyles and the constant availability of ultra-processed foods.


Today on The Dhru Purohit Show, Dhru sits down with Dr. Mike Israetel to discuss how our modern food environment taps into our evolutionary drive to consume and store calories for times of scarcity. Dr. Mike explains why punishing yourself or approaching weight loss with self-hatred is counterproductive and shares a practical guide for sustainable weight loss, no matter your goal. If you’re considering semaglutides, he outlines the key factors for a successful experience. Ready to crush your weight loss goals in 2025? Tune in for these expert tips! 


Dr. Mike, PhD, is the co-founder and Chief Content Officer of RP Strength (Renaissance Periodization) and the face of its popular YouTube channel. With a doctorate in sports physiology from East Tennessee State University, he is a seasoned expert in fitness and performance. As a former sports nutrition consultant for the U.S. Olympic Training Site in Johnson City, Tennessee, Dr. Mike has shared his expertise at global scientific and performance conferences, including seminars at the U.S. Olympic Training Center in Lake Placid. He has coached countless athletes in nutrition and weight training and continues to push his limits as a competitive bodybuilder and professional Brazilian Jiu-Jitsu grappler.


In this episode, Dhru and Dr. Mike dive into:

  • Why the human body is good at storing fat and why it has been a key part of our survival as a species (00:28)
  • Forgiveness and acceptance of your current body while empowering yourself to make changes (10:06)
  • How to lose stubborn fat in a sustainable way (17:13)
  • A balanced and practical approach to fat loss (32:02)
  • The role of obesogens, calories, and seed oils in weight gain (38:45)
  • Hidden calories in foods and how easily we overeat without realizing it (48:34)
  • Weight loss and appetite-suppressing drugs (57:19)
  • Key cultural and genetic differences in obesity levels between the USA, Japan, and other countries (01:10:33)
  • Are semaglutides appropriate for individuals trying to lose less than 30 pounds (01:26:30)
  • How diet can help reduce addictions (01:34:57)
  • The difference between business meals and fun meals (01:41:30)


  • Also mentioned in this episode:

    • Learn more about Dr. Mike and access free guides from RP Strength here



    For more on Dr. Israetel, follow him on Instagram, X/Twitter, YouTube, and his Website.


    This episode is brought to you by Bon Charge, One Skin, and Cozy Earth.


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