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Hi friends! This episode is featuring autophagy scientist Dr. Kurt Escobar on how to upregulate autophagy in humans, dispelling the hype about fasting, Mtor & more! See full bio below.

*TIMESTAMPS BELOW

Studies mentioned in this episode:

Autophagy and aging: Maintaining the proteome through exercise and caloric restriction

Does Exercise Regulate Autophagy in Humans? ASystematic Review and Meta-Analysis

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*TIMESTAMPS

5:00 Kurt's background and interest in studying in autophagy

9:13 what is autophagy?

10:30 why autophagy is important (avoiding disease and aging)

12:00 autophagy as cellular housekeeping

13:00 autophagy, exercise & redox potential

13:30 quantifying exercise vs fasting for autophagy

17:00 no current consensus on how much autophagy is required for humans and implications for longevity and aging

18:00 limitations to longevity research in humans

19:00 problems with extrapolating rodent data to humans

20:00 fasting in mice stimulating ampk/PGC1alpha and mitochondrial biogenesis VS humans according to newest research

21:00 what do exercise and caloric restriction have in common with up regulating autophagy

23:00 metabolic autophagy vs "housekeeping" autophagy

25:40 exercise upregulates the housekeeping autophagy

29:29 intermittent fasting and autophagy

44:30 meta analysis & systematic review on best exercises for autophagy

52:00 autophagy threshold and different types of exercise for autophagy

56:00 mTOR suppression on longevity, disregulated mTor vs "good" mTOR

1:10:00 what is V02 Max? Improving V02 Max for health and longevity

1:15:00 Heat Shock Proteins

1:19:00 cold exposure vs heat exposure for muscle repair and recovery

1:21:00 physiological stressors & benefits

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-Dr. Kurt Escobar completed his PhD at the University of New Mexico. His research centers on how exercise and nutrition can improve human health, function, and performance. His work ranges from exercise metabolism, the effects of exercise and nutrition on metabolic health, and sports nutrition, to the cellular responses to exercise including autophagy. He teaches courses on the physiology of exercise, exercise programming and prescription in health and disease, and exercise nutrition. Check out his Youtube Channel HERE

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