Digital technologies can create confusion among donors in the humanitarian supply chain (HSC), leading to uncertainty about their use. While resilience in HSCs has been widely studied, antifragility has not. This study examines how donor confidence in digital technologies impacts antifragility in HSCs through their application in sourcing, material flow, and distribution, with trust in digital technologies and perceived effective digital technology governance as moderating factors. Using resource dependence theory, data from 296 NGOs were analyzed with partial least squares–based structural equation modeling (PLS-SEM). The findings show that digital technology application is crucial for building an antifragile HSC and that donor confidence and trust in digital technologies are essential. NGOs should focus on enhancing trust and governance perception to facilitate digital transformation in HSCs.