SHR # 2678:: Epigenetics, Longevity and Health-span - Erin Sharoni - Everywhere you turn you hear about the importance of epigenetics. There are now tests that boast the ability of determining your biological age. We hear that through the manipulation of epigenetics we can change our biological age. We know that methylation plays an important role in epigenetics. We also know that some of the epigenetic changes are capable of being passed down through trans-generational effects. We know a lot more about epigenetics today than we did just 5 years ago. What we are yet to understand is what steps to take to effectively change our epigenome to improve not only the length of our lives but the quality and avoidance of disease. Today we will discuss several studies that when tied together give us some answers and actionable steps to improve our own outcome. http://shrnetwork.biz/livebetter Use code SHR for 20% off. Studies Discussed On This Show

Transgenerational Epigenetic Inheritance: Myths and Mechanisms https://www.sciencedirect.com/science/article/pii/S0092867414002864 The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight https://science.sciencemag.org/content/364/6436/eaau8650 Epigenetic changes during aging and their reprogramming potential https://www.tandfonline.com/doi/abs/10.1080/10409238.2019.1570075 Reprogramming to recover youthful epigenetic information and restore vision https://www.nature.com/articles/s41586-020-2975-4 Erosion of the Epigenetic Landscape and Loss of Cellular Identity as a Cause of Aging in Mammals https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3461780 DNA Break-Induced Epigenetic Drift as a Cause of Mammalian Aging https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3466338 The Hallmarks of Aging https://www.sciencedirect.com/science/article/pii/S0092867413006454 SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging https://www.sciencedirect.com/science/article/pii/S0092867408013172 Reprogramming the Epigenome With Vitamin C https://www.frontiersin.org/articles/10.3389/fcell.2019.00128/full Aging and DNA methylation https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-015-0118-4 The aging epigenome https://www.sciencedirect.com/science/article/pii/S1097276516301502