In this episode, Dr. Greg Jones talks with Dr. Tom Ingengno, a Doctor of Acupuncture, author of The Cupping Book, and founder of Charm City Integrative Health. Together, they explore the surprising science behind cupping therapy, from its ancient roots to how it’s finding a place in modern integrative medicine.

Dr. Tom shares how a family memory led him from pre-med to acupuncture, the evolution of cupping practices across cultures, and the science that supports its benefits for circulation, inflammation, and even anxiety. They also discuss how techniques like red light therapy, cryotherapy, and acupuncture can be “stacked” for deeper healing.

Whether you’re a skeptic, a curious wellness enthusiast, or a practitioner, this episode breaks down the myths and explains why cupping isn’t just a trend, it’s a time-tested therapy supported by research and results.

📌 Dr. Tom Ingegno

Dr. Tom Ingegno, DACM is a nationally recognized Doctor of Acupuncture and Chinese Medicine with a reputation for blending ancient healing with modern innovation. With over 20 years of clinical experience, he founded Charm City Integrative Health in Baltimore. In this one-of-a-kind clinic, acupuncture meets cryotherapy, red light therapy, and cutting-edge wellness tools. Known for his relatable style and sharp insights, Dr. Tom has been featured in over 100 podcasts, interviews, and wellness publications. Whether he's helping patients navigate burnout or exploring the science behind Eastern medicine, Dr. Tom is passionate about making holistic care accessible, effective, and rooted in real results.

🔗 Learn more about Dr. Tom Ingegno

Website: Http://charmcityintegrative.com

Instagram: www.instagram.com/acuguy

Podcast: https://irreverenthealth.com

YouTube: http://www.youtube.com/c/CharmCityIntegrativeHealthBaltimore

Connect with Dr. Greg Jones

Instagram: @doctorjones_doctorjones 

Enovative Wellness Center: https://enovativewellness.com/ 

🔬 Timestamps

• Introduction and Dr. Tom’s early inspiration in healthcare (00:00 - 02:41)

• How a memory of his grandfather sparked a shift from pre-med to acupuncture (02:41 - 07:23)

• The evolution of acupuncture from “woo woo” to evidence-based medicine (07:23 - 09:37)

• Understanding qi and how modern science tries to measure energy flow (09:37 - 14:25)

• The real science behind cupping — circulation, fascia, and repair (14:25 - 16:46)

• Myths about cupping marks and what they really mean (16:46 - 19:31)

• The global history of cupping: from ancient Egypt to modern clinics (19:31 - 26:30)

• How cupping triggers the body’s “rest and digest” state (26:30 - 32:38)

• Safety considerations and when not to use cupping (32:38 - 38:28)

• DIY cupping and the safest tools to use at home (38:28 - 49:47)

• How acupuncture and cupping complement each other (49:47 - 51:09)

• Dr. Tom’s “stacked” therapies: red light, cryotherapy, salt therapy, and more (51:09 - 56:44)

• The comeback of ancient medicine in modern science (56:44 - 01:01:16)

• Where to Find Dr. Tom and Closing Remarks (01:01:16 - 01:04:19)

In this episode, Dr. Jones sits down with Eric Stoffers, CEO and founder of BioXcellerator, a global leader in stem cell therapy and regenerative medicine. Stoffers is an international pioneer in health, immunity, and longevity, with a vision to make advanced therapies more accessible for patients with autoimmune, orthopedic, neurological, and degenerative conditions.

From his work at BioXcellerator to his leadership as Chairman of Solutions for a Healthier World, a nonprofit focused on improving lives through medicine, science, and education, Stoffers brings innovation and compassion to the future of healthcare.

Listeners will hear insights on the science behind stem cells, detailing the differences between various sources like adipose tissue, bone marrow, and umbilical cords. They explore the unique properties of mesenchymal stem cells (MSCs), contrasting them with exosomes and addressing common industry myths, including the use of embryonic cells.

You'll hear about the conditions showing the most promising results, from orthopedic and autoimmune issues to neurological injuries like TBIs and spinal cord damage. Eric also discusses the regulatory landscape that differentiates treatment in the U.S. from options abroad, the patient experience at his clinic in Medellin, Colombia, and why he believes regenerative medicine is the present, not the future.

📌 Eric Stoffers

Eric Stoffers is an international pioneer and innovator in stem cell therapy and research. As CEO and founder of BioXcellerator, he has advanced protocols to treat autoimmune and degenerative diseases, orthopedic injuries, spinal and neurological conditions, and more. He also serves as Chairman of Solutions for a Healthier World, a nonprofit dedicated to alleviating suffering and improving quality of life through medicine, education, and support for victims of tragic events.

🔗 Learn more about Eric Stoffers

Website: bioxcellerator.com

LinkedIn: www.linkedin.com/in/eric-stoffers-1853b885/

Connect with Dr. Greg Jones

Instagram: @doctorjones_doctorjones 

Enovative Wellness Center: https://enovativewellness.com/ 

🔬 Timestamps

• Introduction to Stem Cell Therapy (00:00 - 01:09)

• Dr. Jones's Skepticism and First Impressions of BioXcellerator (01:09 - 02:27)

• Eric Stouffer's Journey from Restaurants to Regenerative Medicine (02:27 - 05:13)

• How a Real Estate Deal Led to the Founding of BioXcellerator (05:13 - 07:04)

• Why Colombia and Medellin Were Chosen for BioXcellerator (07:04 - 09:27)

• Foundational Question: What Is a Stem Cell? (09:27 - 11:42)

• What Is a Mesenchymal Stem Cell (MSC)? (11:42 - 13:02)

• Autologous vs. Allogeneic Cells: Addressing Donor Rejection Concerns (13:02 - 14:46)

• MSCs vs. Embryonic and Pluripotent Stem Cells (14:46 - 17:17)

• The Difference Between Stem Cell Products in the U.S. vs. BioXcellerator (17:17 - 22:08)

• Explaining the Difference Between Stem Cells and Exosomes (22:08 - 27:32)

• Conditions with the Best Outcomes: Orthopedic, Autoimmune, and Neurological (27:32 - 31:36)

• Treating Veterans for TBIs and Concussions (31:36 - 33:23)

• Misunderstood and Overstated Claims in the Stem Cell Industry (33:23 - 35:49)

• FDA Regulations: Why Can't We Do This in the States? (35:49 - 38:09)

• The Myth That Stem Cell Therapy Is Unproven (38:09 - 39:15)

• Pros and Cons of Different Stem Cell Sources (Autologous vs. Allogeneic) (39:15 - 42:44)

• How BioXcellerator Measures and Tracks Patient Success Remotely (42:44 - 46:18)

• The Patient Process: From Initial Consultation to Treatment in Medellin (46:18 - 50:35)

• Why Are Large Stem Cell Doses Administered Over Multiple Days? (50:35 - 52:56)

• The Pros and Cons of Medellin (and the Traffic!) (52:56 - 54:25)

• The Future Role of Stem Cells in Regenerative and Longevity Medicine (54:25 - 57:50)

• Advice for Listeners Hesitant About Stem Cell Therapy (57:50 - 01:00:30)

• Advice Eric Would Give Himself 10 Years Ago (01:00:30 - 01:02:43)

• Where to Learn More About BioXcellerator and Closing Remarks (01:02:43 - 01:05:21)

In this episode, Dr. Greg Jones reconnects with Dr. Leonard Pastrana, pharmacist, educator, and co-founder of New Bio Age. Their conversation centers on VO₂ max, what it is, why it matters for healthspan, and how it’s becoming one of the most critical markers in longevity medicine.

They explain what VO₂ max measures, why traditional wearables often fall short, and how metabolic breath analysis provides real clinical data. You’ll hear about the impact of COVID-19 on cardiorespiratory fitness, why training zones (like zone 2 and interval training) matter, and how resistance training also supports VO₂ max.

Dr. Pastrana also talks about the role of peptides, recovery strategies, and supplements such as alpha-ketoglutarate and Leucinergy in supporting mitochondrial function and exercise performance. The episode concludes with a look at the future of metabolic testing, New Bio Age’s Clinical Longevity Certification, and the upcoming CALM 2026 event.

📌 Dr. Leonard Pastrana

Dr. Leonard Pastrana is a pharmacist, co-founder of nuBioAge, and a leader in cellular optimization and longevity medicine. As a Doctor of Pharmacy and faculty member at the American Academy of Anti-Aging Medicine (A4M), he is one of six certified clinical peptide therapy instructors worldwide and the only pharmacist in this role. Leonard empowers medical providers with cutting-edge tools and knowledge through initiatives like Nucleus, consults for pharmacies and supplement companies, and pioneers precision diagnostics, peptide therapies, and integrative health solutions. A sought-after speaker, his work focuses on mentorship, collaboration, and advancing standards in longevity medicine.

🔗 Learn more about Dr. Leonard Pastrana

Website: https://nubioage.com/about/
Instagram: www.instagram.com/leonardpastrana/

🔬 Timestamps

• Introduction and Background (00:00 - 02:12)
• Transition to Longevity and Functional Medicine (02:12 - 05:03)
• The Longevity Summit and Long COVID (05:03 - 08:39)
• Understanding VO₂ Max (08:39 - 12:40)
• Testing Methods for VO₂ Max (12:40 - 19:59)
• VO₂ Max as a Standard for Longevity (19:59 - 26:19)
• Addressing Myths About VO₂ Max Decline (26:19 - 29:04)
• Improving VO₂ Max Through Personalized Exercise (29:04 - 32:00)
• The Role of Resistance Training in VO₂ Max (32:00 - 34:39)
• Peptides and Their Impact on VO₂ Max (34:39 - 42:46)
• The Future of VO₂ Max in Longevity Medicine (42:46 - 44:52)
• Upcoming Events and Educational Opportunities (44:52 - 55:23)

As always, thanks for watching!

Don’t miss an episode! Subscribe and leave a review.

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Disclaimer: The information shared on The Dr. Jones Optimization Podcast and its associated YouTube channel is intended for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Listening to this podcast or viewing its content does not create a doctor–patient relationship, and nothing shared should be interpreted as individualized medical guidance. Always consult with a qualified healthcare provider before making changes to your health regimen or managing a medical condition. The opinions expressed by Dr. Jones and his guests are their own and do not reflect official medical advice or recommendations

In this episode, Dr. Jones talks again with Dr. Paul Anderson, naturopathic doctor, researcher, and teacher. He joined the podcast last year to talk about cholesterol and lipid labs. This time the focus is on NAD (Nicotinamide Adenine Dinucleotide) and why it matters for your health.

They explain what NAD does in the body, especially for energy, brain function, and recovery. You’ll hear how NAD levels drop as we age, how alcohol and medications can drain it faster, and the different ways the body makes NAD on its own.

Dr. Anderson also talks about today’s options, from supplements like NMN, NR, and niacinamide to IV therapy. He shares when IVs make sense, when oral forms might be enough, and what to know about side effects and safety, including the common question about NAD and cancer.

This is a straight talk about NAD, what’s real and what’s hype, and how it can support energy, recovery, and long-term wellness.

📌 Dr. Paul Anderson

Dr. Anderson is an esteemed educator and clinician in integrative and naturopathic medicine, focusing on complex infectious, chronic, and oncologic illnesses, with over three decades of clinical experience. He founded Advanced Medical Therapies for cancer and chronic diseases in Seattle, Washington, and still collaborates with various clinics and hospitals. He has held positions at multiple medical schools, including Professor of Pharmacology and Clinical Medicine at Bastyr University. He has authored several books and articles and is actively involved in continuing medical education through online platforms and conferences.

🔗 Learn more about Dr. Paul Anderson

Website: https://dranow.com

Instagram: www.instagram.com/draonline/

Connect with Dr. Greg Jones

Instagram: @doctorjones_doctorjones 

Enovative Wellness Center: https://enovativewellness.com/ 

🔬 Timestamps
00:00 – Welcome back and introduction

02:35 – What NAD is and why it matters

06:00 – Real benefits vs. hype around NAD

10:49 – Why NAD levels drop

12:27 – How aging and stress affect NAD

18:18 – How the body makes its own NAD

22:10 – How NAD gets into cells

28:39 – NAD precursors and how they work

37:39 – Can you test NAD levels?

44:23 – Using tests to guide treatment

47:42 – IV therapy vs. oral supplements

51:29 – Using NAD for health and recovery

55:41 – IV nicotinamide riboside explained

01:01:26 – Side effects and safety concerns

01:11:22 – CD38 and its role in NAD decline

01:14:36 – Do NAD patches actually work?

01:16:26 – Subcutaneous injections vs. IV therapy

01:19:56 – Where NAD therapy is headed

📣 Subscribe + Follow: Don’t miss an episode! Subscribe and leave a review. 📺 YouTube: https://www.youtube.com/@DrJonesNMDTV 🎧 Spotify: https://open.spotify.com/show/2QrMGwCIGo1kjdezfCyYDK?si=WhH4DW3oQw2k9qkfCtHZdQ 
Disclaimer: The information shared on The Dr. Jones Optimization Podcast and its associated YouTube channel is intended for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Listening to this podcast or viewing its content does not create a doctor–patient relationship, and nothing shared should be interpreted as individualized medical guidance. Always consult with a qualified healthcare provider before making changes to your health regimen or managing a medical condition. The opinions expressed by Dr. Jones and his guests are their own and do not reflect official medical advice or recommendations

In this episode, Dr. Jones is joined by Christina Finnerty, FNP-C—a functional medicine expert specializing in sleep disorders, hormonal health, and regenerative therapies.

Together, they uncover the far-reaching effects of untreated sleep apnea on your brain, heart, metabolism, and even your biological age. Christina shares how obstructive sleep apnea (OSA) accelerates aging, increases the risk of cardiovascular disease, and contributes to cognitive decline and chronic illness.

The conversation also covers practical diagnostics, alternative therapies beyond the CPAP machine, and integrative approaches—including peptides, supplements, and lifestyle interventions—supporting recovery and nervous system regulation.

If you or someone you love struggles with sleep, fatigue, or unexplained symptoms, this episode may provide the missing link.🔗 Learn more about Christina Finnerty, FNP-C Christina Finnerty, FNP-C, provides personalized care for healing, recovery, and wellness, addressing issues like autoimmune disorders, inflammation, pain, brain health, and nervous system concerns. Using advanced testing, including GI mapping, lipid panels, cardiac CT (by referral), and body composition analysis, Christina helps identify the underlying factors of health issues. Christina is passionate about helping patients identify the causes of their health concerns and creating practical, long-term plans to improve wellness, happiness, and longevity.https://ridgelinemedical.org/christin...[email protected] with Dr. Greg JonesInstagram: @doctorjones_doctorjones Enovative Wellness Center: https://enovativewellness.com/ 🔬 Timestamps

• Introduction & the story of how the host was diagnosed with sleep apnea. (00:00 - 02:31)
• Christina's journey into functional medicine and sleep specialization. (02:31 - 05:48)
• What is sleep apnea and why is it so much more dangerous than just snoring? (05:48 - 09:24)
• How sleep apnea accelerates cardiovascular and cognitive aging. (09:24 - 13:43)
• Overlooked signs and symptoms of sleep apnea beyond daytime fatigue. (13:43 - 17:45)
• How sleep apnea symptoms can differ between men and women. (17:45 - 20:37)
• The prevalence of undiagnosed sleep apnea. (20:37 - 24:19)
• Is the cardiovascular and neurological damage from sleep apnea reversible? (24:19 - 25:22)
• The diagnostic process: Comparing home sleep studies vs. in-lab testing. (25:22 - 28:51)
• The difference between obstructive sleep apnea and central sleep apnea. (28:51 - 33:40)
• Treatment options, Part 1: CPAP as the gold standard. (33:40 - 35:54)
• Treatment options, Part 2: Alternatives like oral appliances, surgery, and implants. (35:54 - 39:40)
• Treatment options, Part 3: Positional therapy, mouth taping, and adapting to treatment. (39:40 - 45:30)
• Integrative and functional medicine support (hormones, supplements, peptides). (45:30 - 50:24)
• Unpacking the complex link between testosterone and sleep apnea. (50:24 - 53:06)
• Summary of key takeaways and a call to action for patients and providers. (53:06 - 56:23)
• Closing questions and where to find Christina online. (56:23 - 01:00:15)

📣 Subscribe + Follow: Don’t miss an episode! Subscribe and leave a review. 

📺 YouTube: https://www.youtube.com/@DrJonesNMDTV 

🎧 Spotify: https://open.spotify.com/show/2QrMGwCIGo1kjdezfCyYDK?si=WhH4DW3oQw2k9qkfCtHZdQ  

Disclaimer: The information shared on The Dr. Jones Optimization Podcast and its associated YouTube channel is for informational purposes only. Listening to this podcast or viewing its content does not create a doctor–patient relationship, and nothing shared should be interpreted as individualized medical guidance. Always consult with a qualified healthcare provider before making changes to your health regimen or managing a medical condition. The opinions expressed by Dr. Jones and his guests are their own and do not reflect official medical advice or recommendations.

In this episode, Dr. Jones is joined by Dr. Lauren Fitzgerald—an anesthesiologist-turned-functional medicine leader—to uncover the myths, science, and clinical pearls around testosterone therapy in women.

They explore why testosterone matters far beyond libido, how symptoms of deficiency often get dismissed or misdiagnosed, and what dosing, delivery, and lab markers really tell us. From estrogen dominance to perimenopause, cognitive function to confidence—this episode reveals how hormone optimization can be a game-changer for women at every stage of life.

Whether you’re a provider or a patient, this conversation offers evidence-backed clarity on a topic too often misunderstood.🔗 Learn more about Dr. Lauren Fitzgerald

https://www.larimarmed.com/https://www.instagram.com/drlaurenfitz/Connect with Dr. Greg JonesInstagram: @doctorjones_doctorjones Enovative Wellness Center: https://enovativewellness.com/ 🔬 Timestamps- Introduction to the episode and guest, Dr. Lauren Fitzgerald. (00:00 - 01:50)- Dr. Fitzgerald's story: Transitioning from anesthesiology to functional medicine. (01:50 - 06:06)- How optimizing her own hormones changed Dr. Fitzgerald's life and medical practice. (06:06 - 08:48)- Why is testosterone important for women, and why is it overlooked in traditional medicine? (08:48 - 13:35)- What are the most common signs and symptoms of low testosterone in women? (13:35 - 16:44)- The role of testosterone in brain function, memory, and mood. (16:44 - 17:40)- What are some surprising benefits of testosterone therapy in women? (17:40 - 19:13)- How often are low testosterone symptoms misdiagnosed or dismissed in women? (19:13 - 21:42)- What labs are essential for diagnosing low testosterone? (21:42 - 23:47)- Addressing common patient fears and side effects of testosterone therapy. (23:47 - 30:26)- Does taking testosterone negatively affect a woman's estrogen balance? (30:26 - 33:35)- Dr. Fitz debunks the top myths about testosterone use in women. (33:35 - 36:25)- Comparing delivery methods: Creams vs. injections vs. pellets. (36:25 - 43:22)- What are the optimal testosterone lab ranges for women? (43:22 - 47:47)- How treatment approaches differ for pre-menopausal, perimenopausal, and post-menopausal women. (47:47 - 49:47)- What does Dr. Fitz wish more women and their partners knew about testosterone? (49:47 - 50:20)- Advice for women on how to talk to their doctors about testosterone. (50:20 - 51:44)- What Dr. Fitz would tell her younger self just out of med school. (51:44 - 52:42)- Where listeners can find and learn more from Dr. Fitzgerald. (52:42 - 53:45)📣 Subscribe + Follow: Don’t miss an episode! Subscribe and leave a review. 📺 YouTube: https://www.youtube.com/@DrJonesNMDTV 🎧 Spotify: https://open.spotify.com/show/2QrMGwCIGo1kjdezfCyYDK?si=WhH4DW3oQw2k9qkfCtHZdQ  Disclaimer: The information shared on The Dr. Jones Optimization Podcast and its associated YouTube channel is intended for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Listening to this podcast or viewing its content does not create a doctor–patient relationship, and nothing shared should be interpreted as individualized medical guidance. Always consult with a qualified healthcare provider before making changes to your health regimen or managing a medical condition. The opinions expressed by Dr. Jones and his guests are their own and do not reflect official medical advice or recommendations.

What if an anesthetic known for dental procedures could have a powerful effect on pain, inflammation, and nervous system regulation? Far beyond a numbing agent, Procaine is now being used as a powerful tool to reset the autonomic nervous system and treat chronic pain and stress at a cellular level.Joining me today is Lexi Yoo, a double board-certified Nurse Practitioner, IFM Certified Practitioner, and the founder of Yoo Direct Health. Learn more: @lexiyooNPYDH Training Academy: https://ydhacademy.com/

In this conversation, we explore: • How Procaine IV works beyond anesthesia to influence the nervous, immune, and inflammatory systems • Why it may be one of the best-kept secrets for patients dealing with chronic stress, autoimmune issues, and lingering trauma • What the clinical research tells us after 20+ years of use in Europe and integrative clinics worldwide • And how to implement Procaine safely and effectively in modern clinical practice.

Catch me at: Instagram: @doctorjones_doctorjones Become a patient: https://enovativewellness.com/ 🔬 Timestamps- Intro: Exploring Procaine for Pain, Inflammation & Nervous System Repair (00:00 - 00:58)- Welcoming Lexi Yu & Catching Up (00:58 - 03:20)- Procaine 101: Resetting the Autonomic Nervous System (03:20 - 06:05)- The "Circuit Breaker" Analogy for Nervous System Regulation (06:05 - 07:16)- Mechanism Explained: Procaine's Metabolites and Their Effects (07:16 - 09:59)- Clinical Relevance: Membrane Stabilization and Sympathetic Tone Reduction (09:59 - 11:09)- Patient Presentation: Who Has a Dysregulated Nervous System? (11:09 - 14:23)- Procaine vs. Ketamine and Pairing with EMDR Therapy (14:23 - 17:51)- Who Benefits Most? Ideal Patient Profiles for Procaine Therapy (17:51 - 19:54)- Contraindications and The "Lightning Response" Emotional Release (19:54 - 22:43)- Understanding "Interference Fields" from Past Traumas and Surgeries (22:43 - 24:29)- Dosing & Protocols: Loading and Maintenance Phases (24:29 - 28:45)- What to Expect: Duration of a Procaine IV Session (28:45 - 30:05)- Tracking Outcomes: Subjective Feedback, Oura Ring & Lab Markers (30:05 - 33:16)- Synergistic Therapies: Pairing Procaine with Ozone, Peptides & Prolozone (33:16 - 36:35)- Using Procaine in Regenerative Aesthetics (Hair & Skin) (36:35 - 37:37)- For Practitioners: Where to Learn More About Procaine Therapy (37:37 - 39:33)- Outro: Where to Find Lexi Yu (39:33 - 40:11)- Dr. Jones' Personal Anecdote: Procaine's Effect on His Oura Ring (40:11 - 41:34)📣 Subscribe + Follow: Don’t miss an episode! Subscribe and leave a review. 📺 YouTube: https://www.youtube.com/@DrJonesNMDTV  Disclaimer: The information shared on The Dr. Jones Optimization Podcast and its associated YouTube channel is intended for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Listening to this podcast or viewing its content does not create a doctor–patient relationship, and nothing shared should be interpreted as individualized medical guidance. Always consult with a qualified healthcare provider before making changes to your health regimen or managing a medical condition. The opinions expressed by Dr. Jones and his guests are their own and do not reflect official medical advice or recommendations

What if you could mimic the effects of exercise—without actually hitting the gym? In this episode, Dr. Jones sits down with Anthony Castore, one of the most respected performance and cellular medicine coaches in the country, to explore SLU-PP-332, a compound with powerful mitochondrial and metabolic benefits.Anthony is the founder of DRIVE Longevity Solutions and a Fellow of the SSRP Institute. With over 30 years of high-performance coaching and deep knowledge of cellular biology, he brings unmatched insight into how compounds like SLU-PP-332 can be used to optimize athletic performance, body composition, and even organ repair.We dive into ERR receptors, the PGC1α–AMPK–ERR axis, mitochondrial biogenesis, metabolic flexibility, parasympathetic fat burning, neuroprotective effects, and how to titrate dosing for both patients and elite athletes. Whether you're a clinician, biohacker, or fitness enthusiast, this episode is packed with science and strategy you can use.📌 About Anthony CastoreAnthony Castore is the founder of DRIVE Longevity Solutions and a rare non-physician Fellow of the SSRP Institute. Known for his high-integrity science and no-fluff approach, he blends cutting-edge cellular medicine with decades of elite coaching experience. Anthony works with professional athletes, top-tier executives, and forward-thinking clinicians to design precision protocols for performance and long-term health. Learn more: @anthonycastoreThis episode is brought to you by Tides Health: Code DRJONES for 15% off your first order at https://yourtides.com/ Catch me at: Instagram: @doctorjones_doctorjones Become a patient: https://enovativewellness.com/ 🔬 Timestamps- Intro and Meet Anthony Castore (00:00 - 10:30)- Explaining ERR receptors and non-ligand activation (10:30 - 17:08)- SLU-PP-332 as a mitochondrial agent (17:08 - 19:37)- The PGC1α–AMPK–ERRα axis explained (19:37 - 24:47)- Exercise mimetic vs. exercise replacement (24:47 - 25:12)- Synergy with fasting, cold plunges, and HIIT (25:12 - 30:49)- Real-world results: performance, VO₂, recovery, and body comp (30:49 - 34:23)- Skeletal muscle retention and metabolic flexibility (34:23 - 35:42)- Lipolysis in parasympathetic state: a fat-loss breakthrough (35:42 - 36:32)- Timing SLU-PP-332: morning and post-workout protocols (36:32 - 38:31)- Organ system improvements: liver, kidney, A1C (38:31 - 42:45)- Personalized dosing protocols and titration strategy (42:45 - 43:15)- Measuring metabolic flexibility: RER, Lumen, glucose (43:15 - 47:16)- Dosing sweet spots for men vs. women (47:16 - 48:14)- Mitochondrial support stack: CoQ10, carnitine, NAD, NAC, SS-31 (48:14 - 50:22)- Redox balance: how to detect when you’ve gone too far (50:22 - 53:40)- Side effects and estrogen dominance risks (53:40 - 56:28)- Smart protocols vs. reckless stacking (56:28 - 56:50)- Learning more about SLU-PP-332: mechanisms over marketing (56:50 - 59:01)- Anthony’s final advice: curiosity over intensity (59:01 - 01:00:34)- Outro and where to find Anthony (01:00:34 - 01:03:29) 📣 Subscribe + Follow: Don’t miss an episode! Subscribe and leave a review. 📺 YouTube: https://www.youtube.com/@DrJonesNMDTV 🎧 Spotify: https://open.spotify.com/show/2QrMGwCIGo1kjdezfCyYDK?si=WhH4DW3oQw2k9qkfCtHZdQ Disclaimer: The information shared on The Dr. Jones Optimization Podcast and its associated YouTube channel is intended for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Listening to this podcast or viewing its content does not create a doctor–patient relationship, and nothing shared should be interpreted as individualized medical guidance. Always consult with a qualified healthcare provider before making changes to your health regimen or managing a medical condition. The opinions expressed by Dr. Jones and his guests are their own and do not reflect official medical advice or recommendations.

In this episode, I am joined by Dr. Laura Lile — one of the few U.S. physicians dual-credentialed as both a Registered Pharmacist and a Medical Doctor — to explore how genomics is revolutionizing the future of preventative and precision medicine. Dr. Lile shares her journey from pharmacy innovator to longevity-focused clinician and breaks down how our genetic blueprint, when interpreted through tools like IntellxxDNA, can help guide personalized health strategies that optimize brain health, prevent chronic disease, and extend quality of life.

From pioneering drive-thru pharmacies and concierge telehealth to decoding epigenetic influences and SNP variants, this episode is packed with insight, innovation, and clinical application.

🧬 Topics Covered: • Dr. Lile’s path from pharmacy to medicine and the innovation mindset behind it • The difference between genetics and epigenetics • How lifestyle and environment shape gene expression • Using genomics to prevent chronic illness and optimize longevity • Powerful case studies • How IntellxxDNA supports real-world, clinical decision-making • Future of AI in genomic medicine and personalized health plans👤 About Dr. Laura Lile:Dr. Lile is a nationally recognized expert in functional medicine and one of the rare dual-credentialed professionals certified as both a Pharmacist and an MD. She founded Lile Wellness Partners, where she leads a proactive, genomics-informed approach to longevity, brain optimization, and chronic disease prevention. Her expertise is grounded in decades of pharmacy practice, innovation in telehealth and concierge care, and pioneering genomic testing for personalized treatment plans.This episode is brought to you by:Tides Health: Code DRJONES for 15% off your first order at https://yourtides.com/📍 Resources & Links: • Learn more about Dr. Laura Lile: https://lilewellness.com • IntellxxDNA for clinicians and patients: https://lilewellness.com/genomics • Connect with Dr. Lile directly: [email protected] me at:Instagram: @doctorjones_doctorjonesBecome a patient: https://enovativewellness.com/⏱️ Timestamps:- Intro + Celebrating Mother’s Day (00:00 - 02:52)- Pharmacy to MD: What led Dr. Lile back to medical school (02:52 - 07:45)- Innovating the drive-thru pharmacy at age 25 (07:45 - 09:45)- Concierge telemedicine before it was mainstream (09:45 - 17:16)- Genomics vs. Epigenetics explained (17:16 - 19:13)- Poker, software updates & genetic expression (19:13 - 26:15)- Addressing gene risk without fear: Empowerment through action (26:15 - 31:53)- Barriers clinicians face in learning genomics (31:53 - 35:08)- IntellxxDNA vs. 23andMe: What makes it clinically powerful (35:08 - 41:59)- Real-world case studies: Cancer, Parkinson’s, heart disease (41:59 - 49:19)- Do patients need supplements for life? (49:19 - 51:58)- The role of AI and what excites Dr. Lile about the future (51:58 - 57:46)- Advice Dr. Lile would give her younger self (57:46 - 59:25)📣 Subscribe + Follow:Don’t miss an episode! Subscribe and leave a review.📺 YouTube: https://www.youtube.com/@DrJonesNMDTV🎧 Spotify: https://open.spotify.com/show/2QrMGwCIGo1kjdezfCyYDK?si=WhH4DW3oQw2k9qkfCtHZdQ📸 Instagram: https://www.instagram.com/doctorjones_doctorjones/Disclaimer: The information shared on The Dr. Jones Optimization Podcast and its associated YouTube channel is intended for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Listening to this podcast or viewing its content does not create a doctor–patient relationship, and nothing shared should be interpreted as individualized medical guidance. Always consult with a qualified healthcare provider before making changes to your health regimen or managing a medical condition. The opinions expressed by Dr. Jones and his guests are their own and do not reflect official medical advice or recommendations

In this episode, I’m joined by Shalin Shah, CEO of Marius Pharmaceuticals, to talk about the past, present, and future of testosterone replacement therapy (TRT). From the systemic decline in testosterone levels among younger men to the breakthrough FDA-approved oral testosterone Kyzatrex, this conversation explores what’s next for hormone optimization—and why it matters more than ever.Take a look and listen as we dive deep into the myths around oral testosterone, why SHBG levels matter, how testosterone therapy affects inflammation, cardiovascular risk, cognition, libido, and longevity, and why optimizing free testosterone—not just total T—is the true goal. Plus, we discuss clinical pearls for transitioning from injections or pellets to oral therapy, monitoring labs effectively, and future directions for female testosterone replacement.

Whether you’re a clinician, a patient, or someone interested in living with more energy, drive, and clarity—this episode is a must-listen.🧠 About Shalin Shah:Shalin Shah is the Chief Executive Officer of Marius Pharmaceuticals, a company pioneering innovative therapies to address testosterone deficiency and cardiometabolic disease. With a background in economics, biotech leadership, and healthcare strategy, Shalin has become a leading advocate for rethinking how testosterone is tested, prescribed, and perceived. He’s also the founder of RethinkTestosterone.com, an educational platform for clinicians and patients aiming to shift the paradigm from symptom-based care to proactive, personalized hormone optimization.This episode is brought to you by Tides Health, formulating physician-grade peptide-based supplements designed for performance, recovery, and longevity.🛒 Shop now at yourtides.com — Use code DRJONES for 15% off your first order📍 Resources & Links:• Learn more about Kyzatrex: https://www.kyzatrex.com/• Rethink Testosterone: https://www.rethinktestosterone.com/• 📲 Follow Shalin Shah on Instagram: @TheMetabolicCEO⏱️ TIMESTAMPS:00:00 – Welcome & the testosterone crisis in men01:00 – Meet Shalin Shah: Why testosterone is his mission04:30 – What’s causing the testosterone collapse in younger men?08:15 – Low T symptoms and why “normal” labs can be misleading13:00 – Comparing TRT delivery options: injections, topicals, pellets, and oral16:30 – Why SHBG matters more than you think22:00 – Kyzatrex: Oral testosterone that bypasses the liver26:00 – The importance of dietary fat for oral testosterone absorption33:00 – Estrogen management and why most men don’t need AIs38:00 – TRT and fertility: What the Kyzatrex trials reveal41:00 – How to transition from other TRT forms to oral43:00 – Best practices for lab testing Kyzatrex44:30 – How testosterone affects inflammation, cardiovascular risk & longevity46:00 – Future of TRT for women48:00 – What Shalin would tell his younger self49:00 – Where to learn more about Kyzatrex, Marius, and TRT science📣 Subscribe + Follow:Don’t miss an episode! Subscribe and leave a review.📺 YouTube: https://www.youtube.com/@DrJonesNMDTV🎧 Spotify: https://open.spotify.com/show/2QrMGwCIGo1kjdezfCyYDK?si=WhH4DW3oQw2k9qkfCtHZdQDisclaimer: The information shared on The Dr. Jones Optimization Podcast and its associated YouTube channel is intended for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Listening to this podcast or viewing its content does not create a doctor–patient relationship, and nothing shared should be interpreted as individualized medical guidance. Always consult with a qualified healthcare provider before making changes to your health regimen or managing a medical condition. The opinions expressed by Dr. Jones and his guests are their own and do not reflect official medical advice or recommendations