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By Kent Holtorf, MD
4.2
2828 ratings
The podcast currently has 68 episodes available.
The most played episodes among Podcast App listeners.

I did not plan to give this talk. I arrived at the AIMS Symposium, realized how much of the room was aesthetics, and did not have a single slide on the oral skin bioregulators we have been working on for years. So I rebuilt it. What is happening in that room is worth paying attention to, because beauty and functional medicine are being pushed together and nobody has decided yet whether the plastic surgeons, the regenerative doctors, the orthomolecular people or the naturopaths end up owning it. The premise underneath all of it is simple enough. People who feel good on the inside want to look like it on the outside, and the inside is where the instruction actually gets written. So I skipped my usual hour of theory and went to the data. What a peptide is, what a bioregulator is, and why the distinction matters: peptides bind at the cell surface and signal, while bioregulators are two to four amino acids, small enough to enter the nucleus and sit down on the DNA, turning genes of aging down and youthful ones up, one tissue at a time. Then the skin studies. Sirtuin 1 and 6 and collagen synthesis in young and aged cultures, markers of proliferation and repair going one way, caspase-3 and MMP-9 going the other, and a human trial on a placenta derived dermatologic peptide measuring wrinkle depth, elasticity, hydration and pigment across twelve weeks. After that, the parts of the catalogue people ask me about most: the thyroid bioregulators and the separate thyroid axis version that is the one that touches antibodies, the brain and vascular bioregulators, the pancreas work in type 2 diabetes, muscle and grip strength, and the long-running biologic age trials out of Russia that rotate five to seven bioregulators and track telomere length and methylation age. I also tell the story of where all of this came from, which starts with the Soviet military noticing that its cosmonauts, jet pilots and submariners were aging far faster than they should have been. Take the mechanism seriously and the aesthetic result stops being the goal and starts being the receipt. - - - - - About the Host: Dr. Kent Holtorf, MD has spent most of his career on the patients other clinics send away: tick-borne illness, chronic fatigue syndrome, fibromyalgia, CIRS, mast cell activation, long COVID, and the multi-system cases that never fit one specialty. He is the medical director of Holtorf Medical Group, the founder and medical director of Integrative Peptides, and president and medical director of the National Academy of Hypothyroidism, a nonprofit built around the argument that thyroid diagnosis in the United States has not caught up with its own published literature. He came to peptides as a patient first. Years of chronic Lyme, Babesia, and Bartonella that did not respond to high-dose IV antibiotics ended in heart failure from fibrosis, and it was a course of peptides picked up abroad that turned it around. He has since given close to a hundred CME-approved presentations worldwide, published in peer-reviewed journals, sat on editorial boards in endocrinology and specialty medicine, and written Mold Illness: The Peptide Protocol for the Rapid Treatment of CIRS. This talk is the first time he has taken the bioregulator work into aesthetics. - - - - - Social Handles: Website: https://holtorfmed.comhttps://integrativepeptides.comInstagram: https://www.instagram.com/integrativepephttps://www.instagram.com/holtorfmedicalgroup - - - - - PODCAST Thank you for listening. Please subscribe and share. This podcast is produced by DrTalks.com https://drtalks.com/podcast-service/

What if weight loss isn’t about willpower, but restoring what your body lost along the way? In this episode of Peptides and Longevity, Dave Knapp shares his journey through obesity, type 2 diabetes, GLP-1 therapy, sobriety, and faith, revealing how peptides, lifestyle change, and spiritual surrender reshaped his health and purpose. - - - - - Dave Knapp is a podcaster and founder of On The Pen, an obesity medicine news platform focused on educating patients about metabolic health, GLP-1 therapies, and emerging peptide science. After struggling with lifelong obesity and type 2 diabetes, Dave transformed his health through research, lifestyle change, and integrative approaches combining medication, supplementation, and faith. Through his platform, he helps individuals better understand obesity as a complex metabolic condition while encouraging sustainable health habits, personal responsibility, and long-term wellness. Website: https://onthepen.com Instagram:https://www.instagram.com/onthepen.official/ - - - - - Are you a health practitioner exploring peptide therapies? Learn more at www.integrativepeptides.com and use code PODLIFE for practitioner savings. For AI-driven insights and tools to support peptide protocols, visit www.integrativepeptides.ai - - - - - Holtorf Medical Group Website: https://holtorfmed.com/ Facebook: https://www.facebook.com/holtorfmed/ Instagram: IntegrativePeptides https://www.instagram.com/integrativepep?igsh=MXNjOHpuM3Fpb21hZA== Holtorf Medical Group https://www.instagram.com/holtorfmedicalgroup?igsh=dWhnenZyM3g0ajZk&utm_source=qr NAHIS https://www.instagram.com/nahypothyroidism?igsh=NnUwYWtsZWRkaTRx Kent Holtorf, MD YouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A Produced by DrTalks https://drtalks.com/podcast-service/

In this episode of Peptides and Longevity, Michael McNeal sits down with Melanie Murphy Richter to break down how the ProLon 5-Day Fasting Mimicking Diet is designed to keep you just below key nutrient-sensing pathways so you can access autophagy, support gut balance, and reduce cravings while still eating real food. Melanie Murphy Richter, MS, RDN, is a registered dietitian nutritionist with a background in healthcare PR and a master’s degree in health span and longevity. She runs a private practice focused on gut-centered care for a wide range of conditions, including autoimmune concerns, anxiety, and depression. She is also the Director of Communications at L-Nutra, a longevity science company behind the ProLon 5-Day Fasting Mimicking Diet. Having studied under Valter Longo and completed numerous ProLon cycles herself, Melanie blends clinical insight with practical experience to help people understand fasting science in a way they can actually follow. Website: https://melaniemurphyrd.com/ Instagram: https://www.instagram.com/healthnmellness/ LinkedIn: https://www.linkedin.com/in/melaniegmurphy/ Holtorf Medical Group Website: https://holtorfmed.com/ Facebook: https://www.facebook.com/holtorfmed/ Instagram: https://www.instagram.com/holtorfmedicalgroup/ Kent Holtorf, MD YouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A Produced by DrTalks https://drtalks.com/podcast-service/

Most skincare promises repair, but this goes far beyond that. In this episode of Peptides and Longevity, Debbi Barber, founder of Vitali Skincare, shares how copper peptides remodel damaged skin, improve texture and tone, and support healing after procedures through a discovery that transformed her own skin. Debbi Barber is the founder, creator, and CEO of Vitali Skincare, a peptide-based skincare company focused on true skin remodeling. After discovering the effects of copper peptides on her own skin, she partnered with expert chemists to develop formulations designed for absorption, efficacy, and long-term skin health. Today, Vitali Skincare products are used globally by individuals seeking science-informed skincare that supports healing, resilience, and confidence at every stage of life. Website: https://www.vitaliskincare.com Instagram: https://www.instagram.com/debbibarber/ LinkedIn: https://www.linkedin.com/in/debbibarber Holtorf Medical Group Website: https://holtorfmed.com/ Facebook: https://www.facebook.com/holtorfmed/ Instagram: https://www.instagram.com/holtorfmedicalgroup/ Kent Holtorf, MD YouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A Produced by DrTalks https://drtalks.com/podcast-service/

Most people reach for another coffee when their brain is tired—but what if the real issue is how your brain makes and spends energy? In this episode of Peptides and Longevity, Dr. Gregory Kelly joins us to break down what nootropics are, how caffeine impacts focus and mood, and why mitochondrial health and chronobiology matter for sustainable brain performance. Dr. Gregory Kelly is a naturopathic physician and the director of product development at Neurohacker Collective, where he guides the development of nootropic, mitochondrial, immune, and healthy-aging formulas. He is the author of ‘Shape Shift,’ was editor of the Journal of Alternative Medicine Review, and a contributor to the Textbook of Natural Medicine, with more than 30 publications indexed in PubMed. Before entering naturopathic medicine, he served as a Navy officer and earned an engineering degree, later redirecting his curiosity toward how people and traditional cultures care for their health. He has taught advanced clinical nutrition, counseling skills, and doctor–patient relationships at the University of Bridgeport and the College of Naturopathic Medicine. With over two decades immersed in supplements, natural medicine, and chronobiology, his work centers on nootropics, anti-aging, regenerative medicine, weight management, sleep, and the timing of biological processes that shape performance and health. Website: https://www.qualialife.com/people/greg-kelly LinkedIn: linkedin.com/in/gregory-kelly Visit www.integrativepeptides.com and use the code PODLIFE to get 10% off your first purchase. Holtorf Medical Group Website: https://holtorfmed.com/ Facebook: https://www.facebook.com/holtorfmed/ Instagram: https://www.instagram.com/holtorfmedicalgroup/ Kent Holtorf, MD YouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A Produced by DrTalks https://drtalks.com/podcast-service/
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