Leaky gut isn’t just about digestion—it’s also messing with your brain. In this episode of Peptides and Longevity, Kiran Krishnan, a research microbiologist, breaks down the gut–brain connection and why a leaky gut can fuel inflammation, brain fog, and mood issues. He also reveals groundbreaking research on spore-based probiotics—how they repair the gut lining, calm inflammation, and may even help reprogram metabolism for better energy and body composition.

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A mass extinction is happening inside your gut—and it’s fueling everything from brain fog to autoimmunity. In this episode of Peptides and Longevity, Kiran Krishnan explains why the microbiome is not just trillions of organisms, but a vast genetic toolkit that powers most of our body’s chemistry. He warns that modern living is driving a ‘mass extinction’ of gut species, weakening immune training, fueling leaky gut, and setting the stage for allergies, autoimmunity, and chronic illness.

Krishnan then connects the dots to the brain, showing how toxins from a leaky gut trigger inflammation, brain fog, mood issues, and even neurodegeneration. He shares evidence on how spore-based probiotics restore gut diversity, strengthen keystone species, repair the gut barrier, and lower inflammatory markers—sometimes in as little as a month. Krishnan also highlights a pilot study where spores and prebiotics reduced visceral fat and improved insulin health without diet changes, pointing to true ‘metabolic reprogramming.’ He wraps up with a reality check on overhyped probiotics and testing, urging a smarter, science-based approach to gut health.

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Kiran Krishnan is a research microbiologist with over two decades of experience in the field of nutrition and supplements. Trained in molecular medicine and microbiology at the University of Iowa, he went on to hold leadership roles in global product development before becoming General Manager of Novozymes One Health America, Microbiome Labs. A sought-after speaker at medical and nutrition conferences, he is known for making complex science on the human microbiome practical and accessible. He is actively involved in more than a dozen human clinical trials, serves on multiple scientific advisory boards, and holds peer-reviewed publications and global patents in probiotic and microbiome research.

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Kiran Krishnan

Website: https://microbiomelabs.com/home/

Instagram: https://www.instagram.com/kiranbiome/

Facebook: https://www.facebook.com/kiran.krishnan.9279

LinkedIn: https://www.linkedin.com/in/kiran-k-b302147/

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Integrative Peptides

Website: ⁠https://integrativepeptides.com/⁠

Facebook: ⁠https://www.facebook.com/integrativepeptidesofficial/⁠

Instagram: ⁠https://www.instagram.com/integrativepeptides/⁠

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Holtorf Medical Group

Website: ⁠https://holtorfmed.com/⁠

Facebook: ⁠https://www.facebook.com/holtorfmed/⁠

Instagram: ⁠https://www.instagram.com/holtorfmedicalgroup/⁠

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Kent Holtorf, MD

YouTube: ⁠https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A⁠

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Produced by DrTalks

⁠https://drtalks.com/podcast-service/

Want to heal injuries faster, bounce back from surgery stronger, or even slow aging with your body’s own healing signals? In this episode of Peptides & Longevity, Dr. R. David Calvo reveals how he uses peptides and regenerative therapies to supercharge recovery, protect joints, and help patients feel decades younger.

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Dr. R. David Calvo spent decades as a high-volume orthopedic surgeon before realizing that surgery alone wasn’t enough. So he began exploring regenerative medicine, using platelet-rich plasma, bone marrow, fat-derived stem cell products, and later peptides, to improve not just surgical outcomes, but overall vitality. What he discovered transformed both his patients’ results and his own health: by optimizing the “terrain” of the body, recovery accelerates and performance rebounds.

In this episode of Peptides & Longevity, Dr. Calvo joins us to explain how he now uses targeted peptides alongside regenerative procedures to help patients heal faster, sleep better, and stay strong as they age. He also shares real-world cases of athletes bouncing back from injuries in record time, surgical wounds closing faster, and patients regaining energy and focus by supporting their mitochondria and hormones. His message is simple yet powerful: you don’t have to accept decline—if you give your body the right signals, it can repair itself.

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Dr. R. David Calvo is a board-certified orthopedic surgeon and sports medicine expert with over three decades of experience caring for athletes from high school to professional levels. After decades in surgical practice, he shifted his focus to preventative, regenerative, and anti-aging medicine—founding Texas Center Wellness in Austin, Texas.

Trained through the American Academy of Anti-Aging Medicine and the Age Management Medicine Group, Dr. Calvo now helps patients worldwide through telemedicine, using cutting-edge therapies like peptides, stem cells, exosomes, platelet-rich plasma, and bioidentical hormones to accelerate healing, enhance longevity, and optimize human performance.

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R. David Calvo, MD

Website: https://texascenterwellness.com/

LinkedIn: https://www.linkedin.com/in/dr-david-calvo-698b541a/

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Integrative Peptides

Website: https://integrativepeptides.com/

Facebook: https://www.facebook.com/integrativepeptidesofficial/

Instagram: https://www.instagram.com/integrativepeptides/

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Holtorf Medical Group

Website: https://holtorfmed.com/

Facebook: https://www.facebook.com/holtorfmed/

Instagram: https://www.instagram.com/holtorfmedicalgroup/

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Kent Holtorf, MD

YouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A

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Produced by DrTalks  https://drtalks.com/podcast-service/

What if your lingering fatigue, brain fog, or pain isn’t ‘just in your head’ but the result of hidden biotoxins disrupting your immune system and energy production? In this episode of Peptides & Longevity, Dr. Cory Tichauer unpacks the complex world of biotoxin illness—from mold and heavy metals to chronic infections—and shares how accurate testing, binder strategies, and targeted peptides can restore balance, repair mitochondria, and help you reclaim lasting health.

It’s not just mold—it’s mold plus metals, infections, and a body stuck in survival mode. In this episode of Peptides & Longevity, Dr. Cory Tichauer joins us to explain that biotoxin illness is rarely just about mold—it’s the combined effect of environmental toxins like pesticides, heavy metals, and solvents, along with hidden infections such as Lyme. For some people, genetic patterns make it harder to clear these toxins, trapping them in a cycle of chronic inflammation that disrupts hormones, damages mitochondria, and fuels symptoms like fatigue, brain fog, pain, and sleep issues. He connects this to the ‘cell danger response,’ where overwhelmed cells shut down energy production and repair in an attempt to protect themselves—leaving patients stuck in survival mode.

Dr. Tichauer’s treatment approach follows a seven-step roadmap: remove exposures, stop toxins from recirculating with binders and bile support, and then restore balance step by step. Peptides play a key role in calming inflammation, repairing tissue, and helping the immune and hormonal systems reset—offering patients a path to true recovery when standard medicine falls short. Watch the episode now to learn how to break free from the cycle of toxins and reclaim your health.

Dr. Cory Tichauer is a naturopathic physician and founder of Bear Creek Naturopathic Clinic in Medford, Oregon. With a background in neurobiology and medical training focused on integrative and functional care, he has spent almost two decades treating complex chronic conditions. His clinical expertise spans tick-borne infections, mold and biotoxin illness, autoimmune disorders, and neurodegeneration. 

A member of both the International Lyme and Associated Diseases Society and the International Society for Environmentally Acquired Illness, Dr. Tichauer is recognized for his systems-based approach, which combines thorough diagnostic workups with targeted therapies to restore immune regulation, mitochondrial health, and neuroendocrine balance. Today, he is recognized for integrating peptides into biotoxin and chronic illness protocols to help patients recover when standard treatments have failed.

Dr. Cory Tichauer

Website: https://www.bearcreekclinic.com/

Instagram: https://www.instagram.com/bearcreekclinic/

Facebook: https://www.facebook.com/bearcreekclinic

Integrative Peptides

Website: https://integrativepeptides.com/

Facebook: https://www.facebook.com/integrativepeptidesofficial/

Instagram: https://www.instagram.com/integrativepeptides/

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Holtorf Medical Group

Website: https://holtorfmed.com/

Facebook: https://www.facebook.com/holtorfmed/

Instagram: https://www.instagram.com/holtorfmedicalgroup/

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Kent Holtorf, MD

YouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A

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Produced by DrTalks  https://drtalks.com/podcast-service/

Can drinking hydrogen water really restore your gut, boost your mitochondria, and slow aging? In this episode of Peptides & Longevity, Dr. Paul Barattiero joins us to explain the history of hydrogen water, its medical applications, and current research. We discuss how molecular hydrogen functions as a selective antioxidant and impacts pathways, telomerase, and mitochondria. 

Dr. Barattiero emphasizes the importance of gut terrain: after antibiotics and environmental chemicals, restoring the gut’s electrical potential and microbial balance is essential, and dissolved hydrogen may support this process. He suggests mimicking natural gut fermentation by drinking hydrogen water several times per day. He also touches on spacing hydrogen from ozone therapy, field experiences ranging from energy and sleep to vision and reflux anecdotes, and briefly outlines his team’s electromagnetic field solution that depolarizes radiation and lowers signal strength in a defined area.

Dr. Paul Barattiero is a leading voice in the field of molecular hydrogen and the founder of Echo Water. His journey began nearly two decades ago when his wife’s chronic illnesses weren’t improving with conventional medicine. After discovering the power of dissolved hydrogen in water, he dove deep into the research and witnessed firsthand the profound impact it had on her health. Inspired by her transformation, he dedicated his career to advancing hydrogen technology and making it accessible for both patients and practitioners. Today, he develops innovative solutions that support gut health, reduce oxidative stress, and even protect against electromagnetic fields.

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Dr. Paul Barattiero

Website: https://echowater.com/

Instagram: https://www.instagram.com/echohydrogen/?hl=en

LinkedIn: https://www.linkedin.com/company/echohydrogen/

Facebook: https://www.facebook.com/echohydrogen

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Integrative Peptides

Website: https://integrativepeptides.com/

Facebook: https://www.facebook.com/integrativepeptidesofficial/

Instagram: https://www.instagram.com/integrativepeptides/

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Holtorf Medical Group

Website: https://holtorfmed.com/

Facebook: https://www.facebook.com/holtorfmed/

Instagram: https://www.instagram.com/holtorfmedicalgroup/

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Kent Holtorf, MD

YouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A

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Produced by DrTalks  https://drtalks.com/podcast-service/

Want to look younger, feel stronger, and live longer? Start with these six foundations. In this episode of Peptides & Longevity, Dr. Michael Meighen explores the six foundations of true vitality—sleep, nutrition, movement, stress balance, and hormone health—as the cornerstones of longevity and aesthetics. He also shares the latest regenerative therapies, peptides, and biohacking tools that help patients heal, look younger, and extend their healthspan.

Peptides, stem cells, and hormone optimization are powerful—but only if the foundations are solid. In this episode of Peptides & Longevity, Dr. Michael Meighen joins us to bring a holistic and evidence-based approach to anti-aging, musculoskeletal health, and aesthetics. He stresses the importance of “lower-hanging fruit” like restorative sleep, proper nutrition, stress management, and movement, noting that no therapy works unless these foundations are in place. He also explains how balancing cortisol, optimizing diet to control blood sugar and insulin, and embracing lifestyle practices like time in nature and intentional exercise are key to healing and longevity.

Dr. Meighen also introduces regenerative and functional interventions that extend beyond traditional medicine. He highlights the benefits of prolotherapy, platelet-rich plasma, stem cells, and certain peptides for joint repair, aesthetics, and recovery. The conversation expands into hormone optimization for mood, brain health, and vitality, as well as biohacking tools like hyperbaric oxygen therapy, infrared sauna, and cold immersion. He emphasizes symmetry, functional movement, and personalized testing as markers of true vitality—helping patients not just live longer, but thrive with confidence and energy.

Dr. Michael Meighen is a physician, author, and health optimization specialist focused on regenerative medicine, aesthetics, and total body transformation. Board-certified in physical medicine, rehabilitation, and pain medicine, he brings over two decades of experience helping patients restore mobility, reduce pain, and extend vitality through conservative, non-operative treatments.

Dr. Meighen is the bestselling author of A New You: Using the Body’s Regenerative and Restorative Powers to Optimize Orthopedic, Hormonal, and Sexual Health Function and a contributing author to The Codes of Longevity. He integrates advanced regenerative therapies—including platelet-rich plasma, stem cells, and peptide protocols—with hormone optimization, fitness strategies, and biohacking tools to help his patients achieve peak performance and aesthetic confidence. His mission is to empower people to live longer, stronger, and healthier lives by addressing root causes and unleashing the body’s innate healing power.

Michael Meighen

LinkedIn: https://www.linkedin.com/in/michael-meighen-6a882316b/

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Integrative Peptides

Website: https://integrativepeptides.com/

Facebook: https://www.facebook.com/integrativepeptidesofficial/

Instagram: https://www.instagram.com/integrativepeptides/

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Holtorf Medical Group

Website: https://holtorfmed.com/

Facebook: https://www.facebook.com/holtorfmed/

Instagram: https://www.instagram.com/holtorfmedicalgroup/

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Kent Holtorf, MD

YouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A

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Produced by DrTalks  https://drtalks.com/podcast-service/

Your libido isn’t gone—it’s just waiting for the right support. In this episode of Peptides & Longevity, Dr. Nick Delgado joins us to dive into the science and practice of creating a fulfilling sex life that lasts well into later years. From communication and intimacy strategies to hormone optimization and peptide therapy, he shares practical ways to boost vitality, intimacy, and longevity.

In this episode of Peptides & Longevity, Dr. Nick Delgado challenges cultural myths and common misunderstandings about sexual health, intimacy, and performance. He explains that while 95% of men believe they are great lovers, the majority of women report not experiencing orgasm in their relationships—a disconnect rooted in lack of communication, inadequate foreplay, and male insecurity. Drawing on decades of research and clinical practice, Dr. Delgado emphasizes that true intimacy depends on dialogue, patience, and understanding women’s unique physiology.

Beyond the bedroom, he explores how lifestyle and science intersect to extend both sexual vitality and life itself. He outlines the importance of hormone optimization, detoxification of harmful estrogens, plant-based nutrition, adrenal support, and the use of certain peptides. These tools, he argues, not only enhance sexual performance but also improve longevity, immune function, and quality of life. The conversation is both entertaining and deeply educational, offering actionable strategies for couples and individuals seeking to feel younger, healthier, and more connected.

Website: https://nickdelgado.com/

Instagram: https://www.instagram.com/dr.nickdelgado/

Facebook: https://www.facebook.com/theagedoc

YouTube: https://www.youtube.com/@DelgadoProtocol

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Integrative Peptides

Website: https://integrativepeptides.com/

Facebook: https://www.facebook.com/integrativepeptidesofficial/

Instagram: https://www.instagram.com/integrativepeptides/

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Holtorf Medical Group

Website: https://holtorfmed.com/

Facebook: https://www.facebook.com/holtorfmed/

Instagram: https://www.instagram.com/holtorfmedicalgroup/

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Kent Holtorf, MD

YouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A

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Produced by DrTalks  https://drtalks.com/podcast-service/

Want to use peptides safely and effectively? In this episode of Peptides & Longevity, Dr. Kathleen O’Neil-Smith joins us to distill decades of clinical experience into a discussion on peptides for pain relief, fascia health, brain injury recovery, immune balance, and performance optimization. She shares real-world cases, practical protocols, and her philosophy on starting safely and effectively with these powerful tools.

In this episode of Peptides & Longevity, Dr. Kathleen O’Neil-Smith gives us a masterclass on the diverse applications of peptides in clinical practice. Drawing from her background in internal medicine, functional medicine, regenerative therapies, and athletic coaching, she explains how specific peptides can be matched to the type of injury or dysfunction—whether that’s joint degeneration, fascia restriction, immune imbalance, or neurotrauma. She emphasizes the importance of fascia as an interconnected signaling network and outlines how combining physical manipulation with targeted injections or intravenous therapy can produce rapid, lasting results.

Dr. O’Neil-Smith also details her personal experience using peptides to restore her son’s health after a severe traumatic brain injury, walking through the specific compounds, timing, and combinations she used for inflammation control, nerve regeneration, and whole-body recovery. The conversation expands into immune system assessment, gut-brain connections, mitochondrial health, performance optimization for elite athletes, and strategies for healthy aging. Throughout, she underscores that the key to success is starting somewhere with safe, foundational peptides and adapting as the patient’s needs evolve.

Dr. Kathleen O’Neil-Smith is a physician, lecturer, and researcher specializing in peptides, regenerative medicine, and functional health. A magna cum laude graduate of Boston University School of Medicine, she completed postgraduate training in pathology at Harvard/Mass General and internal medicine at Brigham and Women’s Hospital. With additional certifications in stem cell therapies, traumatic brain injury treatment, and exercise physiology, she has served as founder of the International Peptide Society and Clinical Peptide Society, and as a senior lecturer at leading medical conferences worldwide. Known for her innovative, compassionate approach, Dr. O’Neil Smith integrates advanced peptide protocols, medicinal signaling therapies, and performance strategies to help patients—from elite athletes to complex chronic cases—achieve optimal health and recovery.

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Integrative Peptides

Website: https://integrativepeptides.com/

Facebook: https://www.facebook.com/integrativepeptidesofficial/

Instagram: https://www.instagram.com/integrativepeptides/

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Holtorf Medical Group

Website: https://holtorfmed.com/

Facebook: https://www.facebook.com/holtorfmed/

Instagram: https://www.instagram.com/holtorfmedicalgroup/

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Kent Holtorf, MD

YouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A

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Produced by DrTalks  https://drtalks.com/podcast-service/

Meet the bioregulators: the small but mighty peptides rewriting the science of aging. In this episode of Peptides & Longevity, Jean-François Tremblay joins us to explore the fascinating world of peptide bioregulators, their origins, and their profound impact on health and aging. He explains how these small yet powerful molecules can support immune function, hormone balance, and organ health while offering remarkable safety and adaptability.

In this episode of Peptides & Longevity, Jean-François Tremblay joins us to explain peptide bioregulators—small chains of amino acids with the potential to revolutionize modern medicine. He shares the surprising history of their discovery during the Cold War and how early studies revealed their ability to influence longevity, immune function, and organ repair. Tremblay explains that while over 25 peptide bioregulators are currently well-studied, discoveries continue to expand our understanding of their therapeutic promise.

He highlights certain peptides that have shown benefits for anti-aging, hormonal health, fertility, and joint support. Tremblay emphasizes their unique ability to adapt to the body’s state, working like “intelligent molecules” that restore balance without forcing unwanted effects. This episode offers a compelling look at why peptides could shape the future of preventive and regenerative medicine.

Jean-François Tremblay is a biochemist and pharmacology expert with over two decades of experience in peptide research and application. He completed his undergraduate studies in biochemistry, mechanical engineering, and kinesiology before earning a master’s degree in pharmacology.

He has consulted on peptides for anti-aging, sports performance, and overall health, and founded his own company specializing in the synthesis of peptides. Tremblay is widely respected for making complex science approachable, combining a wealth of knowledge with a passion for helping people live healthier, longer lives.

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Integrative Peptides

Website: https://integrativepeptides.com/

Facebook: https://www.facebook.com/integrativepeptidesofficial/

Instagram: https://www.instagram.com/integrativepeptides/

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Holtorf Medical Group

Website: https://holtorfmed.com/

Facebook: https://www.facebook.com/holtorfmed/

Instagram: https://www.instagram.com/holtorfmedicalgroup/

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Kent Holtorf, MD

YouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A

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Produced by DrTalks  https://drtalks.com/podcast-service/

Why is no one talking about pelvic health? In this episode of Peptides & Longevity, Dr. Betsy Greenleaf sheds light on the often-overlooked world of pelvic health. She discusses the root causes of incontinence, pelvic pain, and chronic infections—revealing certain peptides that offer safe, effective, and holistic options for healing and prevention.

Dr. Betsy Greenleaf is a urogynecologist, entrepreneur, and women’s health advocate with over two decades of experience specializing in pelvic medicine and reconstructive surgery. She made history as the first female in the United States to become board-certified in urogynecology, and she continues to lead the field with a holistic, patient-centered approach to care.

Dr. Greenleaf is also the CEO of The Pelvic Floor Store, an online marketplace dedicated to providing reliable products for pelvic health. She also hosts Some of Your Parts Podcast, where she explores the mind-body-spirit connection in women’s wellness. Recognized as a Distinguished Fellow of the American College of Osteopathic Obstetrics and Gynecology, she is a sought-after speaker, educator, and media contributor, dedicated to breaking the silence around pelvic health and empowering women with innovative, effective solutions.

Dr. Betsy Greenleaf

://pelvicfloorstore.com/

LinkedIn: http://linkedin.com/in/drbetsygreenleaf/

Instagram: https://www.instagram.com/drbetsygreenleaf/

Facebook: https://www.facebook.com/dr.betsy.greenleaf

YouTube: https://www.youtube.com/@dr.betsygreenleaf7401

TikTok: https://www.tiktok.com/@drbetsygreenleaf

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Integrative Peptides

Website: https://integrativepeptides.com/

Facebook: https://www.facebook.com/integrativepeptidesofficial/

Instagram: https://www.instagram.com/integrativepeptides/

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Holtorf Medical Group

Website: https://holtorfmed.com/

Facebook: https://www.facebook.com/holtorfmed/

Instagram: https://www.instagram.com/holtorfmedicalgroup/

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Kent Holtorf, MD

YouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A

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Produced by DrTalks  https://drtalks.com/podcast-service/

Discover how your gut’s microbial balance affects everything from stress to drug absorption. In this episode of Peptides & Longevity, Afif Ghannoum joins us to unpack the science of the gut microbiome and reveals how imbalances in this ecosystem can disrupt digestion, drug effectiveness, stress response, and immunity.

In this episode of Peptides & Longevity, Afif Ghannoum, a biotechnology entrepreneur, breaks down the emerging science of the total microbiome—including bacteria, fungi, and viruses—and its massive impact on digestion, disease, drug response, and overall health. He shares insights from his father, Dr. Mahmoud Ghannoum, who coined the term ‘mycobiome’ and has led groundbreaking research into how fungi and bacteria form biofilms in the gut, driving inflammation and digestive disorders. Together, they developed BIOHM Health to bring this research to consumers with innovative testing and probiotic solutions.

Afif also reveals surprising truths—like how stress, over-exercise, and restrictive diets can damage the microbiome, and how fungi aren’t inherently bad but vital to gut balance. He explains why prebiotics (dietary fibers that nourish good microbes) may be more important than probiotics alone, and how proper microbial balance affects pain, stress response, immunity, and even medication effectiveness. This is a powerful conversation for anyone who’s struggled with gut issues, chronic symptoms, or confusion about which ‘health rules’ to follow.

Afif Ghannoum

Website: https://www.biohmhealth.com/

LinkedIn: https://www.linkedin.com/in/afifghannoum/

Instagram: https://www.instagram.com/biohmhealth/

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Integrative Peptides

Website: https://integrativepeptides.com/

Facebook: https://www.facebook.com/integrativepeptidesofficial/

Instagram: https://www.instagram.com/integrativepeptides/

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Holtorf Medical Group

Website: https://holtorfmed.com/

Facebook: https://www.facebook.com/holtorfmed/

Instagram: https://www.instagram.com/holtorfmedicalgroup/

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Kent Holtorf, MD

YouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A

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Produced by DrTalks  https://drtalks.com/podcast-service/