Want to use peptides safely and effectively? In this episode of Peptides & Longevity, Dr. Kathleen O’Neil-Smith joins us to distill decades of clinical experience into a discussion on peptides for pain relief, fascia health, brain injury recovery, immune balance, and performance optimization. She shares real-world cases, practical protocols, and her philosophy on starting safely and effectively with these powerful tools.

In this episode of Peptides & Longevity, Dr. Kathleen O’Neil-Smith gives us a masterclass on the diverse applications of peptides in clinical practice. Drawing from her background in internal medicine, functional medicine, regenerative therapies, and athletic coaching, she explains how specific peptides can be matched to the type of injury or dysfunction—whether that’s joint degeneration, fascia restriction, immune imbalance, or neurotrauma. She emphasizes the importance of fascia as an interconnected signaling network and outlines how combining physical manipulation with targeted injections or intravenous therapy can produce rapid, lasting results.

Dr. O’Neil-Smith also details her personal experience using peptides to restore her son’s health after a severe traumatic brain injury, walking through the specific compounds, timing, and combinations she used for inflammation control, nerve regeneration, and whole-body recovery. The conversation expands into immune system assessment, gut-brain connections, mitochondrial health, performance optimization for elite athletes, and strategies for healthy aging. Throughout, she underscores that the key to success is starting somewhere with safe, foundational peptides and adapting as the patient’s needs evolve.

Dr. Kathleen O’Neil-Smith is a physician, lecturer, and researcher specializing in peptides, regenerative medicine, and functional health. A magna cum laude graduate of Boston University School of Medicine, she completed postgraduate training in pathology at Harvard/Mass General and internal medicine at Brigham and Women’s Hospital. With additional certifications in stem cell therapies, traumatic brain injury treatment, and exercise physiology, she has served as founder of the International Peptide Society and Clinical Peptide Society, and as a senior lecturer at leading medical conferences worldwide. Known for her innovative, compassionate approach, Dr. O’Neil Smith integrates advanced peptide protocols, medicinal signaling therapies, and performance strategies to help patients—from elite athletes to complex chronic cases—achieve optimal health and recovery.

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Integrative Peptides

Website: https://integrativepeptides.com/

Facebook: https://www.facebook.com/integrativepeptidesofficial/

Instagram: https://www.instagram.com/integrativepeptides/

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Holtorf Medical Group

Website: https://holtorfmed.com/

Facebook: https://www.facebook.com/holtorfmed/

Instagram: https://www.instagram.com/holtorfmedicalgroup/

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Kent Holtorf, MD

YouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A

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Produced by DrTalks  https://drtalks.com/podcast-service/

Meet the bioregulators: the small but mighty peptides rewriting the science of aging. In this episode of Peptides & Longevity, Jean-François Tremblay joins us to explore the fascinating world of peptide bioregulators, their origins, and their profound impact on health and aging. He explains how these small yet powerful molecules can support immune function, hormone balance, and organ health while offering remarkable safety and adaptability.

In this episode of Peptides & Longevity, Jean-François Tremblay joins us to explain peptide bioregulators—small chains of amino acids with the potential to revolutionize modern medicine. He shares the surprising history of their discovery during the Cold War and how early studies revealed their ability to influence longevity, immune function, and organ repair. Tremblay explains that while over 25 peptide bioregulators are currently well-studied, discoveries continue to expand our understanding of their therapeutic promise.

He highlights certain peptides that have shown benefits for anti-aging, hormonal health, fertility, and joint support. Tremblay emphasizes their unique ability to adapt to the body’s state, working like “intelligent molecules” that restore balance without forcing unwanted effects. This episode offers a compelling look at why peptides could shape the future of preventive and regenerative medicine.

Jean-François Tremblay is a biochemist and pharmacology expert with over two decades of experience in peptide research and application. He completed his undergraduate studies in biochemistry, mechanical engineering, and kinesiology before earning a master’s degree in pharmacology.

He has consulted on peptides for anti-aging, sports performance, and overall health, and founded his own company specializing in the synthesis of peptides. Tremblay is widely respected for making complex science approachable, combining a wealth of knowledge with a passion for helping people live healthier, longer lives.

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Integrative Peptides

Website: https://integrativepeptides.com/

Facebook: https://www.facebook.com/integrativepeptidesofficial/

Instagram: https://www.instagram.com/integrativepeptides/

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Holtorf Medical Group

Website: https://holtorfmed.com/

Facebook: https://www.facebook.com/holtorfmed/

Instagram: https://www.instagram.com/holtorfmedicalgroup/

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Kent Holtorf, MD

YouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A

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Produced by DrTalks  https://drtalks.com/podcast-service/

Why is no one talking about pelvic health? In this episode of Peptides & Longevity, Dr. Betsy Greenleaf sheds light on the often-overlooked world of pelvic health. She discusses the root causes of incontinence, pelvic pain, and chronic infections—revealing certain peptides that offer safe, effective, and holistic options for healing and prevention.

Dr. Betsy Greenleaf is a urogynecologist, entrepreneur, and women’s health advocate with over two decades of experience specializing in pelvic medicine and reconstructive surgery. She made history as the first female in the United States to become board-certified in urogynecology, and she continues to lead the field with a holistic, patient-centered approach to care.

Dr. Greenleaf is also the CEO of The Pelvic Floor Store, an online marketplace dedicated to providing reliable products for pelvic health. She also hosts Some of Your Parts Podcast, where she explores the mind-body-spirit connection in women’s wellness. Recognized as a Distinguished Fellow of the American College of Osteopathic Obstetrics and Gynecology, she is a sought-after speaker, educator, and media contributor, dedicated to breaking the silence around pelvic health and empowering women with innovative, effective solutions.

Dr. Betsy Greenleaf

://pelvicfloorstore.com/

LinkedIn: http://linkedin.com/in/drbetsygreenleaf/

Instagram: https://www.instagram.com/drbetsygreenleaf/

Facebook: https://www.facebook.com/dr.betsy.greenleaf

YouTube: https://www.youtube.com/@dr.betsygreenleaf7401

TikTok: https://www.tiktok.com/@drbetsygreenleaf

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Integrative Peptides

Website: https://integrativepeptides.com/

Facebook: https://www.facebook.com/integrativepeptidesofficial/

Instagram: https://www.instagram.com/integrativepeptides/

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Holtorf Medical Group

Website: https://holtorfmed.com/

Facebook: https://www.facebook.com/holtorfmed/

Instagram: https://www.instagram.com/holtorfmedicalgroup/

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Kent Holtorf, MD

YouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A

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Produced by DrTalks  https://drtalks.com/podcast-service/

Discover how your gut’s microbial balance affects everything from stress to drug absorption. In this episode of Peptides & Longevity, Afif Ghannoum joins us to unpack the science of the gut microbiome and reveals how imbalances in this ecosystem can disrupt digestion, drug effectiveness, stress response, and immunity.

In this episode of Peptides & Longevity, Afif Ghannoum, a biotechnology entrepreneur, breaks down the emerging science of the total microbiome—including bacteria, fungi, and viruses—and its massive impact on digestion, disease, drug response, and overall health. He shares insights from his father, Dr. Mahmoud Ghannoum, who coined the term ‘mycobiome’ and has led groundbreaking research into how fungi and bacteria form biofilms in the gut, driving inflammation and digestive disorders. Together, they developed BIOHM Health to bring this research to consumers with innovative testing and probiotic solutions.

Afif also reveals surprising truths—like how stress, over-exercise, and restrictive diets can damage the microbiome, and how fungi aren’t inherently bad but vital to gut balance. He explains why prebiotics (dietary fibers that nourish good microbes) may be more important than probiotics alone, and how proper microbial balance affects pain, stress response, immunity, and even medication effectiveness. This is a powerful conversation for anyone who’s struggled with gut issues, chronic symptoms, or confusion about which ‘health rules’ to follow.

Afif Ghannoum

Website: https://www.biohmhealth.com/

LinkedIn: https://www.linkedin.com/in/afifghannoum/

Instagram: https://www.instagram.com/biohmhealth/

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Integrative Peptides

Website: https://integrativepeptides.com/

Facebook: https://www.facebook.com/integrativepeptidesofficial/

Instagram: https://www.instagram.com/integrativepeptides/

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Holtorf Medical Group

Website: https://holtorfmed.com/

Facebook: https://www.facebook.com/holtorfmed/

Instagram: https://www.instagram.com/holtorfmedicalgroup/

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Kent Holtorf, MD

YouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A

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Produced by DrTalks  https://drtalks.com/podcast-service/

Could balancing this overlooked system be the key to recovering from COVID-19? In this episode of Peptides & Longevity, Dr. Leo Galland joins us to unpack the critical role of the angiotensin pathway and peptides in addressing inflammatory bowel disease and even complications from COVID-19. He also shares insights into balancing the body’s natural systems to prevent infection, heal inflammation, and restore health.

In this episode of Peptides & Longevity, Dr. Leo Galland dives deep into the science behind the angiotensin pathway and how its imbalance plays a major role in the severity of infections from COVID-19. He explains how the angiotensin pathway protects the heart, brain, and blood vessels, and how the virus hijacks this system to wreak havoc. He explores how blocking furin with peptides could prevent the virus from replicating at its first point of entry, the nose.

Dr. Galland also highlights his pioneering work with certain peptides for treating inflammatory bowel disease and other gut conditions. He shares practical, individualized strategies that go far beyond one-size-fits-all medicine, emphasizing the importance of the gut microbiome, the viral biome, and how these emerging tools can help patients heal when mainstream treatments fail. This is a must-watch for anyone curious about the future of peptides, immune health, and personalized healing.

Dr. Leo Galland is a board-certified internist and recognized leader in integrative and functional medicine, specializing in the evaluation and treatment of patients of all ages with complex chronic disorders. A graduate of Harvard University and the New York University School of Medicine, he has pioneered the study of the gut microbiome and intestinal permeability decades before they became mainstream, transforming how we understand the links between digestive health, inflammation, and immune resilience.

Known for developing innovative nutritional therapies for autoimmune, inflammatory, allergic, infectious, and gastrointestinal conditions, Dr. Galland views the doctor-patient relationship as a true partnership, empowering people to take control of their own healing journey. His groundbreaking work has earned him multiple awards, including the Linus Pauling Award from the Institute for Functional Medicine and the Albert Nelson Marquis Lifetime Achievement Award. He serves on the medical advisory board of The Global Lyme Alliance and the Long Covid Advisory Group of the World Health Network, continuing to push the boundaries of what’s possible in personalized medicine.

Website: https://www.drgalland.com/

Facebook: https://www.facebook.com/leogallandmd/ 

Instagram: https://www.instagram.com/dr.leogalland/

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Integrative Peptides

Website: https://integrativepeptides.com/

Facebook: https://www.facebook.com/integrativepeptidesofficial/

Instagram: https://www.instagram.com/integrativepeptides/

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Holtorf Medical Group

Website: https://holtorfmed.com/

Facebook: https://www.facebook.com/holtorfmed/

Instagram: https://www.instagram.com/holtorfmedicalgroup/

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Kent Holtorf, MD

YouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A

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Produced by DrTalks  https://drtalks.com/podcast-service/

Toxins, trauma, and the protocol that changed everything. Can it work for you, too? In this episode of Peptides & Longevity, Scott Forsgren joins us to share his powerful journey recovering from chronic Lyme disease and mold illness after decades of misdiagnoses and struggle. He breaks down his protocol for healing complex chronic conditions, focusing on root causes like toxins, environment, and emotional trauma.

In this episode of Peptides & Longevity, Scott Forsgren, a functional diagnostic nutrition practitioner, joins us to open up about his journey recovering from chronic Lyme disease and mold illness. After a tick bite left him battling intense symptoms and misdiagnoses, he shares how he refused to settle for ‘it’s all in your head,’ instead uncovering deeper root causes like hidden infections, mold exposure, and environmental toxins.

Scott also details his proven protocol that starts with detoxification and drainage, optimizing your external environment, and calming the limbic system. From emotional trauma work to sleep and immune modulation, he explains why true recovery goes far beyond antibiotics—and how new tools like energetic testing and peptides can help restore the body’s natural balance. Packed with practical tips and hope, this is a must-watch for anyone dealing with Lyme, mold illness, or other complex chronic conditions.

Scott Forsgren, FDN-P, NC, is a globally recognized health coach, researcher, and educator specializing in complex chronic illnesses like Lyme disease and mold illness. As the founder of BetterHealthGuy.com and host of the BetterHealthGuy Blogcast, he has spent over two decades interviewing the world’s leading integrative and functional medicine experts, translating his own recovery journey into practical, hope-filled guidance for others.

Scott is a passionate advocate for empowering patients to look beyond symptom suppression and address the terrain that allows illness to thrive. He serves on the Board of Directors for the LymeLight Foundation, has written for numerous publications, and organizes the annual Forum for Integrative Medicine, bringing together top practitioners to share cutting-edge solutions. Whether it’s detoxification, drainage, peptides, or mind-body healing, his mission is clear: to help people reclaim their health—and their hope.

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Scott Forsgren, FDN-P, NC

Website: https://www.betterhealthguy.com/

LinkedIn: https://www.linkedin.com/in/sforsgren/

Facebook: https://www.facebook.com/BetterHealthGuy 

Instagram: https://www.instagram.com/betterhealthguy/

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Integrative Peptides

Website: https://integrativepeptides.com/

Facebook: https://www.facebook.com/integrativepeptidesofficial/

Instagram: https://www.instagram.com/integrativepeptides/

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Holtorf Medical Group

Website: https://holtorfmed.com/

Facebook: https://www.facebook.com/holtorfmed/

Instagram: https://www.instagram.com/holtorfmedicalgroup/

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Kent Holtorf, MD

YouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A

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Produced by DrTalks  https://drtalks.com/podcast-service/

What if peptides could transform cancer treatment? In this episode of Peptides & Longevity, Dr. Leigh Erin Connealy joins us to share her pioneering approach to integrative cancer care—blending conventional treatments with cutting-edge peptide therapies and personalized protocols. She also discusses how early detection, immune optimization, and patient-specific regimens are transforming outcomes for cancer patients.

In this episode of Peptides & Longevity, Dr. Leigh Erin Connealy, a leading voice in integrative oncology, joins us to bring an inspiring and personal perspective to cancer treatment. Dr. Connealy details her evolution from conventional medicine to pioneering a multifaceted, whole-body approach to healing. Fueled by her own health challenges and a passion for prevention, she outlines how she integrates traditional cancer care with advanced diagnostics, immune optimization, and peptide therapies to improve patient outcomes radically.

Dr. Connealy highlights the power of peptides like Thymosin Alpha 1 and PNC-27, as well as how tests such as RGCC and cancer profiles allow her to tailor treatments with precision. From tackling fatty liver and high blood sugar in cancer patients to using laser and intravenous therapies for non-toxic, targeted support, her clinic is a hub for innovation. Her mission is clear: shift the paradigm from reactionary to proactive medicine, and give patients real hope and control over their healing.

Dr. Leigh Erin Connealy is a globally recognized leader in integrative and functional medicine, specializing in comprehensive cancer care and chronic illness prevention. As the Medical Director of the Center for New Medicine and the Cancer Center for Healing in Irvine, California, Dr. Connealy has spent over three decades developing a revolutionary approach to cancer treatment—one that blends the best of conventional medicine with advanced integrative therapies, personalized diagnostics, and cutting-edge peptide protocols.

Known for her commitment to early detection, immune system optimization, and root-cause healing, Dr. Connealy and her team offer multi-disciplinary, patient-centered care that addresses the full complexity of disease. She is the author of ‘The Cancer Revolution and Be Perfectly Healthy,’ and a frequent educator, speaker, and mentor to practitioners worldwide. Her mission is bold but clear: to transform the cancer care model from reactive to proactive—and to help every patient not just fight cancer, but thrive.

Dr. Leigh Erin Connealy

Website: https://cancercenterforhealing.com/

LinkedIn: https://www.linkedin.com/in/leigherinconnealy/  

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Integrative Peptides

Website: https://integrativepeptides.com/

Facebook: https://www.facebook.com/integrativepeptidesofficial/

Instagram: https://www.instagram.com/integrativepeptides/

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Holtorf Medical Group

Website: https://holtorfmed.com/

Facebook: https://www.facebook.com/holtorfmed/

Instagram: https://www.instagram.com/holtorfmedicalgroup/

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Kent Holtorf, MD

YouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A

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Produced by DrTalks  https://drtalks.com/podcast-service/

Lyme disease, mold toxicity, or immune system imbalances causing you difficulties? In this episode of Peptides & Longevity, Dr. Nafysa Parpia joins us to dive into her clinical approach to treating patients with complex chronic illnesses using a layered methodology that blends detoxification, immune modulation, and peptide therapy. She reveals how peptides like BPC-157 and TB4 are revolutionizing care by accelerating recovery timelines and restoring vitality, even in the sickest of patients.

In this episode of Peptides & Longevity, Dr. Nafysa Parpia shares her clinical framework for treating patients with some of the most stubborn and misunderstood chronic illnesses. She explains why detoxification must be the foundation of any treatment plan. Dr. Parpia outlines how intravenous therapies, immune-balancing peptides, and lifestyle changes work together to restore a patient’s capacity to heal, especially when conventional medicine fails to offer answers.

She emphasizes how peptides such as BPC-157, TB4, TA1, and LL-37 have revolutionized her treatment approach, providing faster symptom relief and more sustainable results. These peptides not only regulate immune responses but also help reduce pain, enhance detoxification, and even aid in neurological recovery. Dr. Parpia discusses real-life patient outcomes, including stories of patients regaining energy, eliminating pain, and experiencing rapid healing after years of struggle. This interview is a must-listen for anyone facing a complex illness or treating it.

Dr. Nafysa Parpia is a leading integrative and functional medicine doctor specializing in complex chronic illness, environmental toxicity, and immune dysregulation. Based at Gordon Medical Associates in Santa Rosa, California, Dr. Parpia is known for treating patients with conditions like Lyme disease, mold illness, autoimmune disorders, mast cell activation, and chronic fatigue—often those who have exhausted conventional options and are still searching for answers.

Dr. Parpia has developed a unique clinical methodology that blends deep detoxification, advanced peptide therapy, immune modulation, and regenerative medicine. She’s recognized for her detective-like approach—using functional diagnostics to uncover hidden infections, immune imbalances, and toxic burdens that other practitioners often miss. In addition to her clinical work, she’s a respected educator and speaker at top conferences, including the International Lyme and Associated Diseases Society and the Environmental Health Symposium. She serves on the board of the Neurohacker Collective. Her mission is clear: to help patients not just survive, but truly heal.

Website: https://drparpia.com/

Facebook: https://www.facebook.com/dr.nafysa

LinkedIn: https://www.linkedin.com/in/dr-nafysa-parpia/

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Integrative Peptides

Website: https://integrativepeptides.com/

Facebook: https://www.facebook.com/integrativepeptidesofficial/

Instagram: https://www.instagram.com/integrativepeptides/

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Holtorf Medical Group

Website: https://holtorfmed.com/

Facebook: https://www.facebook.com/holtorfmed/

Instagram: https://www.instagram.com/holtorfmedicalgroup/

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Kent Holtorf, MD

YouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A

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Produced by DrTalks  https://drtalks.com/podcast-service/

In this episode, I sit down with Dr. Farshid Rahbar to explore why so many digestive issues come with non-GI symptoms like fatigue, skin rashes, and brain fog. We dig into fungal overgrowth, stealth infections, and how peptides like BPC-157 and TB4-Frag may help restore gut integrity and systemic health.

In this episode, I talk with Dr. Farshid Rahbar about how digestive disorders often present with non-digestive symptoms like fatigue, skin issues, and brain fog. He shares how fungal overgrowth, stealth infections, and environmental toxins can fuel chronic GI problems, and why conventional tests often miss the mark. We explore peptide therapy, comprehensive testing, and his holistic strategy for treating complex patients.

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Integrative Peptides

Website: https://integrativepeptides.com/

Facebook: https://www.facebook.com/integrativepeptidesofficial/

Instagram: https://www.instagram.com/integrativepeptides/

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Holtorf Medical Group

Website: https://holtorfmed.com/

Facebook: https://www.facebook.com/holtorfmed/

Instagram: https://www.instagram.com/holtorfmedicalgroup/

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Kent Holtorf, MD

YouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A

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Produced by DrTalks  https://drtalks.com/podcast-service/

Could peptides be the key to restarting stalled healing? In this episode of Peptides & Longevity, Dr. Eric Gordon shares a paradigm-shifting perspective on chronic illness through the lens of metabolomics, mitochondrial function, and the cell danger response. He reveals how chronic conditions are less about broken systems and more about misfiring healing cycles—and where peptides may help guide recovery.

In this episode of Peptides & Longevity, Dr. Eric Gordon unpacks decades of insight into the root mechanisms behind chronic illness. He introduces listeners to metabolomics—a scientific field that tracks thousands of small molecules in the body to reveal hidden dysfunctions in metabolism, inflammation, and mitochondrial signaling. Dr. Gordon explains how chronic fatigue syndrome and other illnesses may stem from a prolonged ‘cell danger response,’ where the body gets trapped in a state of protective shutdown, despite the original threat having passed.

Dr. Gordon discusses the implications of this model on diagnosis and treatment. Standard labs often fail to capture these dynamics, leading to misdiagnosis or dismissal of real suffering. Instead, he advocates for understanding the cell’s healing phases, especially the role mitochondria play not just in energy production, but in immune communication. He also touches on the powerful potential of peptides like BPC-157 and thymosins, which can nudge the body out of chronic inflammation and support more complete healing. This conversation reframes chronic illness from a frustrating mystery into a process we can finally begin to understand—and influence.
Dr. Eric Gordon is a pioneering integrative physician with over four decades of clinical experience specializing in complex chronic illness. As the founder of Gordon Medical Associates and president of the Gordon Medical Research Center in the San Francisco Bay Area, he has dedicated his career to helping patients who often fall through the cracks of conventional medicine—those with chronic fatigue syndrome, Lyme disease, fibromyalgia, mast cell activation, and autoimmune conditions.

A passionate collaborator and educator, Dr. Gordon co-authored the groundbreaking study ‘Metabolic Features of Chronic Fatigue Syndrome’ published in the Proceedings of the National Academy of Sciences. This work introduced the revolutionary concept of the cell danger response, a framework that redefines chronic illness as a stuck healing process rather than ongoing damage. Today, Dr. Gordon continues to explore how metabolomics, mitochondrial health, and peptides intersect to reshape diagnosis and treatment in chronic disease. His work bridges research and real-world care, empowering both practitioners and patients to think differently and act more effectively.

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Dr. Eric Gordon

Website: https://www.gordonmedical.com/  

Instagram: https://www.instagram.com/gordonmedical/ 

LinkedIn: https://www.linkedin.com/in/eric-gordon-2329ba30/ 

Facebook: https://www.facebook.com/gordonmedical

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Integrative Peptides

Website: https://integrativepeptides.com/

Facebook: https://www.facebook.com/integrativepeptidesofficial/

Instagram: https://www.instagram.com/integrativepeptides/

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Holtorf Medical Group

Website: https://holtorfmed.com/

Facebook: https://www.facebook.com/holtorfmed/

Instagram: https://www.instagram.com/holtorfmedicalgroup/

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Kent Holtorf, MD

YouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A

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Produced by DrTalks  https://drtalks.com/podcast-service/