 Contrary to findings from observational studies which are inherently affected by bias, digoxin use in randomised controlled trials (RCTs) did not lead to excess mortality in our meta-analysis of 87 studies. There is evidence that digoxin can reduce heart failure-related deaths and hospitalizations. This has implications in treating concomitant atrial fibrillation and heart failure, with two RCTs currently underway to improve our evidence base.       In this interview, Asgher Champsi MD, and Alison L. Bailey MD, FACC discuss ESC Late-Breaker: DIG-META: Digoxin in heart failure and atrial fibrillation.      Subscribe on Apple Podcasts | Subscribe on Google Play | Subscribe to ACCEL  

ESC Hot Line: DIG-META: Digoxin in Heart Failure and Atrial Fibrillation

The American College of Cardiology offers select interviews and summaries of cardiology’s most interesting research areas from ACCEL’s renowned library, hosted by ACCEL Editor-in-Chief Alison L. Bailey, MD, FACC, FAACPVR.

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 The Be Active trial demonstrates the efficacy of scalable interventions, incorporating remote monitoring and behavioral economics, in boosting physical activity among high-risk cardiovascular patients. Lasting effects were observed even six months post-intervention. While additional data may be warranted for some stakeholders, these interventions hold promise as integral components of exercise-based prevention strategies for cardiovascular disease.    In this interview, Alexander Fanaroff, MD, MHS and Glenn A. Hirsch MD, MHS, FACC discuss results from the Be Active RCT.        Subscribe on Apple Podcasts |    

Be Active RCT: Gamification & Financial Incentives to Increase Physical Activity

 The VICTORION-INIATATE study demonstrated that initiating inclisiran, a highly potent lipid-lowering therapy, upon failure to achieve lipid targets with statins, yielded superior outcomes compared to standard care. This approach facilitated a greater proportion of patients in reaching LDL-C targets recommended by current guidelines. Presently, the conventional management of cholesterol disorders in the US routinely falls short of attaining treatment goals for the majority of patients.    In this interview, Michael J. Koren, MD, FACC, and C. Noel Bairey Merz, MD, FACC discuss results from the VICTORION-INITIATE randomized trial.  

Statin Intolerance, Inclisarin, and the VICTORION-INITIATE Trial

 Heart failure is an increasingly recognized complication in chronic diabetes that may be caused by a number of processes including direct effects of hyperglycemia on the heart muscle. So-called diabetic cardiomyopathy may affect up to 20% of people with chronic diabetes and represents a unique target for treatment.     In this interview, James Januzzi, MD, FACC, and Alison L. Bailey, MD FACC discuss the primary results from the ARISE-HF study: Selective Aldose Reductase Inhibitor  For Diabetic Cardiomyopathy.     Subscribe on Apple Podcasts | Subscribe on Google Play | Subscribe to ACCEL  

ARISE-HF Primary Results: Selective Aldose Reductase Inhibitor For Diabetic Cardiomyopathy

 It's becoming increasingly evident that alongside top-notch clinical expertise, the CV specialist of the future must be surrounded by a multi-talented, diverse team to provide optimal patient care. In addition, it is crucial that the clinician and CV organization engage in non-clinical competencies to enhance value for patients, the healthcare system, and society. MedAxiom and ACC collaborate synergistically toward achieving these goals.    In this interview, Jerry Blackwell MD, MBA, FACC and Joseph E. Marine MD, MBA, FACC, discuss The Future of Cardiology - Value-Based Care, Private Equity and the Practice Landscape.         Subscribe on Apple Podcasts | Subscribe on Google Play | Subscribe to ACCEL  

The Future of Cardiology - Value-Based Care, Private Equity and the Practice Landscape

 Patients with acute myocardial infarction are at a high risk of heart failure and death. Despite advances in care and reduction in the rate of recurrent myocardial infarctions, the risk for heart failure continues to be unacceptably high. No intervention in 2 decades has been shown to improve this risk.     In this interview, Javed Butler, MD, MPH, MBA, and Sun Moon Kim, MD, FACC, discuss the results of the EMPACT-MI trial.  

ESC Hot Line: DIG-META: Digoxin in Heart Failure and Atrial Fibrillation

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