Mast cell activation syndrome isn’t widely recognized, but for many women, it may explain years of pain, fatigue, and hormone related chaos no one could solve.

I see a lot of patients who are struggling with fatigue, pain, and hormone symptoms that don’t seem to make sense on paper. And I’ve noticed a pattern but I wanted to talk to someone who lives in the complexity of it every day.

Dr. Tania Dempsey, is one of the few physicians who’s helped bring mast cell activation syndrome (MCAS) into the spotlight. Years ago, she was treating a patient who just wasn’t getting better until she stumbled on a paper about mast cells that changed everything. That one article led to a phone call, a new way of thinking, and a career shifting collaboration with one of the leading voices in the field.

In this conversation, we explore how MCAS shows up in gynecology especially in cases involving PCOS, perimenopause, and unexplained pelvic pain. We discuss why some patients are unusually sensitive to progesterone, how inflammation fuels insulin resistance, and what’s actually going on when mast cells become overactive. We also get into the clinical triad so many of us see MCAS, hypermobility, and POTS and how they often appear together in patients who are struggling to get answers.

Tania also talks about how she built her practice by spending more time listening to her patients and trusting that their symptoms meant something, even when the labs didn’t show it. 

• What mast cells do and how they become overactive in MCAS.
• The overlooked link between PCOS, perimenopause, and mast cell dysfunction.
• Why some patients react badly to progesterone—and what to do about it.
• How GLP-1 drugs like Ozempic may help calm inflammation in MCAS.
• What to know before seeking a diagnosis or starting treatment.

If this episode opened your eyes or gave you language for what you’ve been going through, please subscribe, leave a review, and drop a comment. I’d love to hear what resonated most with you.

Dr. Dempsey's Bio:

Dr. Tania Dempsey, MD, ABIHM is a world-renowned expert in complex, multisystem diseases. As founder of the AIM Center of Personalized Medicine, in Purchase, NY, Dr. Dempsey uses functional and integrative medicine to get to the patient’s root cause(s) of illness and to help them find a path to optimum health. Her extensive knowledge and experience with Mast Cell Activation Syndrome, Mold, and Lyme and other Vector-Borne Diseases, has propelled her to the forefront of the medical community as a recognized and trusted speaker, researcher, advocate, and physician.

Dr. Dempsey is Board-Certified in Internal Medicine and Integrative and Holistic Medicine. She received her MD degree from The Johns Hopkins University School of Medicine and her BS degree from Cornell University. She completed her Internal Medicine Residency at NYU Medical Center.

She was recently elected to the Board of Directors of ILADS (International Lyme and Associated Diseases Society). She is also a member of the U.S. ME/CFS Clinician Coalition, the American Academy of Ozonotherapy, and ISSWSH (International Society for the Study of Women’s Sexual Health).

She is an accomplished international speaker, writer and thought leader and has 8 peer-reviewed articles in the medical literature. Her latest endeavor is cohosting the new podcast, Mast Cell Matters.

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You’re doing everything right. You're on hormones, you’ve cut the caffeine, maybe you’ve even bought one of those expensive sleep trackers. So why are you still waking up at 3am, wired and restless?

In this episode, I sit down with Dr. Andrea Matsumura—board-certified sleep physician and women’s health specialist—to finally unpack why sleep is such a persistent struggle for women, especially during perimenopause and menopause. Andrea breaks down the biological, psychological, and cultural reasons why women are conditioned to expect poor sleep—and why it doesn’t have to be that way.

We talk melatonin myths (the dose matters), the silent epidemic of undiagnosed sleep apnea in women, and why most wearables are only telling part of the story. Andrea also explains why cannabis, supplements, and even hormone therapy may help—but won’t fix the root cause for many women.

Plus, we get into the real reason cognitive behavioral therapy for insomnia (CBT-I) actually works—if you’re willing to do the work—and how the entire medical system is failing women by ignoring gender-specific data in sleep studies and diagnostics.

If you’re tired of being tired and want real, practical answers—not just another supplement or influencer sleep hack—this conversation is for you.

• Why hormone therapy helps some women sleep—but not all.
• How sleep apnea presents differently in women and often goes undiagnosed.
• The truth about melatonin: why most people take the wrong dose at the wrong time.
• Cannabis and sleep: what the research really shows.
• Why CBT-I is the gold standard for insomnia (and why apps alone aren’t enough).

Do you like what you heard? Don’t forget to subscribe, like, and leave a comment on Apple Podcasts your support helps us reach more listeners who deserve better answers.

Guest Bio:

Dr. Andrea Matsumura MD MS FACP FAASM is a board certified sleep specialist and menopause expert, event and corporate speaker, group facilitator, co-founder of the Portland Menopause Collective, and creator of the Sleep Goddess MD D.R.E.A.M. Sleep Method™ and Sleep Goddess Archetype™.

Dr. Matsumura attended medical school at The University of Texas Health Science Center in San Antonio. She moved to Portland, Oregon for her residency in Internal Medicine and was an Internal Medicine Physician with Northwest Permanente for 13 years before entering her fellowship in Sleep Medicine. She attended Oregon Health and Science University as a fellow in Sleep Medicine. She became a partner at The Oregon Clinic in Pulmonary, Critical Care, and Sleep Medicine after completing her fellowship. During her tenure there she focused on women’s health and became a sought-after expert on women and sleep. She is currently the Medical Director of primary care services and medical home development for Cascadia Health in Portland, Oregon and has plans to develop sleep services.

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If you've ever been told "just relax" while in vulvovaginal pain, you're not alone—and you're definitely not crazy. This conversation is about the silent epidemic women keep getting dismissed over.

This episode hit me hard. Not because the stories were shocking—but because they weren’t. Dr. Chailee Moss joined me to talk about the groundbreaking study she co-authored, recently published in JAMA, that finally puts numbers to the gaslighting so many of our patients experience.

We dug into what dismissal looks like in a medical setting and how phrases like "have a glass of wine" or "your exam is normal" can cause lasting harm. For patients living with vulvovaginal pain, being told it’s "all in your head" is not just invalidating—it can delay care, destroy trust, and lead people to give up entirely.

Dr. Moss shared how her own experiences as a patient shaped her path as a physician. We also talked about the deep-rooted system issues in training and documentation that continue to reinforce doubt instead of compassion. The problem isn’t just one bad doctor. It’s a medical culture that doesn't know how to listen to women in pain.

This isn’t just about statistics. It’s about rebuilding the broken parts of medicine so more women feel seen, heard, and actually treated. If you’ve felt dismissed by the system or know someone who has, this episode is for you.s

Highlights:

• Why patients with vulvovaginal pain are often told to "just relax".
• The power of naming gaslighting and measuring it in clinical care.
• How medical training creates blind spots around pain and gender.
• The importance of early diagnosis to prevent years of unnecessary suffering.
• Resources and organizations helping patients find the right care.

If this episode resonated with you, please subscribe, leave a review, and share it with someone who needs to hear it. Let’s keep pushing for better care.

Dr. Moss’s Bio: 

Dr. Chailee Moss is a gynecologist specializing in vulvovaginal disorders in Washington, D.C.   She first became interested in vulvovaginal disorders at the University of North Carolina at Chapel Hill where she earned an M.D. in 2013. She engaged in research on pain and gynecologic surgery during residency training in Ob/Gyn at The Ohio State University where she was a chief of resident education  and earned awards for her research and clinical care. 

Upon graduation, Dr Moss joined the faculty at Johns Hopkins University where she continued to research pain and publish original research in this and other areas.   Dr. Moss is board certified by the American Board of Obstetrics and Gynecology and has been an active member of the Society for Academic Specialists in OB/GYN, serving on the research committee and paper award committee. In her free time she enjoys cooking, camping, and travel with her husband and their three energetic children in Baltimore, MD.

Resources:

Book

Jama Article

Tight Lipped

Dr. Rahman with Tight Lipped

Isswsh

The National Vulvodynia Association

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What if the pain isn’t just physical—and what if fixing the body is only half the battle?

Sexual pain is one of the most misunderstood issues in medicine. I invited my friend and colleague Dr. Corey Babb to dive into why so many women still struggle with pain, even after their doctors tell them everything looks “normal.” Corey just released his new book A Practical Guide for Female Sexual Medicine, which aims to help clinicians actually treat sexual dysfunction—not just study it.

We unpack the deeper reasons patients experience conditions like vaginismus, vestibulodynia, and hypertonic pelvic floor, including trauma, religious shame, and outdated medical training. Corey and I also explore the groundbreaking Pacik method for treating vaginismus, including why Botox and dilators can truly change lives (and minds).

But as we both know, treatment is never just about the body. We talk about the psychological side of healing—including why some patients avoid intimacy even after their pain resolves. Corey shares his insights on retraining the brain, rebuilding trust, and supporting patients beyond the exam room.

We also discuss why pelvic pain is so often dismissed, how to empower women to advocate for themselves, and why our field still has so much work to do when it comes to teaching clinicians about sexual health.

If you’ve ever been told to “just relax” or “drink some wine” to fix your pain—you’ll want to hear this.

Highlights:

• Why sexual pain can persist even after physical treatment
• How trauma and religious shame impact vaginismus
• The Pacik method: Botox and dilator therapy explained
• Why desire and intimacy often lag behind pain relief
• The critical need for better sexual health education in medicine

If this episode helped you feel seen or gave you new insights, please leave a review on Apple Podcasts and share the episode with someone who might need it. Your reviews help more people find this important information and advocate for their health!

Dr. Babb’s Bio:

Dr. Corey Babb is a Tulsa native who has dedicated his life to bringing awareness and acceptance to female sexual health. Through education, activism, and empathy, he helps people feel heard and validated, empowering them to find answers in a complicated medical environment. 

In addition to being a board-certified gynecologist, he is a Fellow of the International Society for the Study of Women’s Sexual Health, a Menopause Society Certified Menopause Practitioner and a member in the International Society for the Study of Vulvovaginal Disorders. Currently, Dr. Babb serves on the board of directors for ISSWSH, is a reviewer for multiple sexual medicine journals, is a respected lecturer and educator, and has been featured in numerous national and international publications, as well as the author of A Practical Guide to Female Sexual Medicine (CRC Press).

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What if the biggest reason women stop life-saving treatment isn't the medication—but clinicians talk to them about it?

In this eye-opening episode, I talk with Dr. Janeane Anderson, a powerhouse researcher and faculty member at the International Society for the Study of Women’s Sexual Health, about the hidden reasons so many women stop taking critical medications like tamoxifen. It’s not just about the side effects—it’s about the silence surrounding them.

We dig into her research on how poor communication, racial bias, trauma, and lack of sexual health conversations lead to lower adherence rates, especially for Black women. We also explore the idea of epistemic injustice—how patients are often dismissed, even when they know something is wrong. Janeane shares how this harm shows up in the room and what clinicians can do to build trust and improve care.

From religious shame to relationship dynamics, sexual trauma, and systemic inequality, this conversation doesn’t shy away from the messy, painful, and very real barriers women face in their health journeys. But we also talk about hope—what it looks like to listen better, ask different questions, and create safer spaces for patients to advocate for themselves.

If you're a patient who's ever felt unheard, or a clinician who wants to do better, this one's for you.

Highlights:

• Why Black women are disproportionately affected by advanced-stage breast cancer.
• The link between sexual dysfunction and stopping cancer treatment.
• How religion, shame, and duty shape sexual health after diagnosis.
• What epistemic injustice means and how it plays out in exam rooms.
• Simple but powerful questions doctors can ask to avoid retraumatizing patients.

If this episode resonated with you, please hit subscribe, leave a review on Apple Podcasts, and share it with someone who needs to hear it. Let’s change how we talk about women's health—together.

Dr. Janeane N. Anderson Bio:

Janeane N. Anderson is an Assistant Professor in the Department of Community and Population Health in the College of Nursing at the University of Tennessee Health Science Center (UTHSC) in Memphis, TN. Dr. Anderson completed postdoctoral research fellowships at Emory University and UTHSC. She earned a Ph.D. in Communication and a Master of Public Health degree from the University of Southern California.

Dr. Anderson’s research targets the relationship between patient-clinician communication practices and clinical and quality of life outcomes among Black adults with chronic health conditions, specifically breast cancer, HIV/AIDS, and vulvovaginal and pelvic pain.

Past extramural funding from National Cancer Institute supported studies that explored patient-clinician communication, treatment adherence, and sexual health challenges among women with early-stage, HR+ breast cancer. Funding from the Washington DC Center for AIDS Research supported development of a shared decision-making tool to improve uptake of pre-exposure prophylaxis (PrEP) among Black sexual minority men; the Tennessee Department of Health funding supported development and implementation of a training for healthcare professional students to improve communication practices for PrEP education and counseling.

Currently, she is the Co-PI of a $1.58 million industry-sponsored grant to investigate multilevel barriers to healthcare access and utilization among Black women with de novo metastatic breast cancer and those with increased risk for advanced breast disease in the U.S. Mid-South region.

Dr. Anderson’s professional activities also include developing faculty resources and university-level programming to address diversity, equity, and inclusion goals and objectives. She is frequently invited to give lectures on systems of oppression, patient-centered communication practices, and sensitive and socially relevant topics within U.S. healthcare system for national and international organizations.

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Is it just mood swings—or something deeper? If you’ve ever felt like a completely different person before your period, you’re not alone—and you’re not crazy.

I’m diving into something I see all the time in my practice: mood disruption during perimenopause that goes far beyond PMS. We’re talking about that "I don’t feel like myself" feeling that so many women deal with—and the deeper hormonal patterns behind it.

PMDD (Premenstrual Dysphoric Disorder) is real. It’s not just feeling irritable—this is a full-body, mind-altering shift that can wreck relationships, sabotage careers, and leave you wondering what the hell is going on. And during perimenopause, those symptoms can go from bad to unbearable.

I’m breaking down the science behind why some women are more sensitive to hormonal fluctuations, how PMDD is diagnosed and the surprising connection to earlier menopause and severe hot flashes. You’ll also hear my thoughts on treatment options—from cognitive therapy to hormonal suppression.

If you’ve been dismissed, told to just “relax,” or handed a birth control pill that made everything worse… this episode is for you.

Highlights:

• What PMDD really is—and how it’s different from regular PMS
• How perimenopause can trigger or worsen mood disorders
• The overlooked connection between progesterone sensitivity and mental health
• Why some women with PMDD enter menopause earlier
• Treatment options that go beyond the pill (including a smart use of Duavee)

If this episode hit home, please like, share, and leave a review on Apple or Spotify. And follow me on Instagram and YouTube @GynoGirlTV for more unfiltered women's health talk.

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What if your low libido isn’t about hormones at all? What if the mental load you're carrying is quietly draining your desire?

So many women come to me wondering what happened to their sex drive. They blame hormones, aging, or even themselves—but rarely do they consider the daily grind of their own lives. In this episode, I'm diving into a topic that sparked massive discussion at a recent sexual health conference: how gender dynamics in heterosexual relationships can play a major role in low desire.

Inspired by a presentation from sex therapist and author Dr. Laurie Mintz, we explore what happens when women take on more of the housework, childcare, and emotional labor in a relationship. We talk about why inequities in household duties, blurred lines between caregiving and romance, and constantly running a mental to-do list all add up to a complete libido crash.

This episode isn’t just about identifying the problem—it’s about understanding how chronic stress, hormonal shifts, and societal expectations intersect to shape your sexual experience. I also share actionable insights from clinical work and research that can help you reconnect with your own pleasure and reframe desire on your own terms.

Whether you're in a long-term relationship or just trying to rediscover what pleasure looks like for you, this is the conversation that might finally explain what no one else has.

Highlights:

• The 2021 study linking gender roles to low sexual desire in heterosexual couples
• Why the division of household labor can quietly kill intimacy
• How chronic stress and role overload affect hormones and sexual arousal
• Actionable strategies to reclaim desire, from scheduling "trysts" to sensory mindfulness
• The impact of perceived unfairness and caregiving dynamics on sexual connection

If this episode resonated with you, please like, comment, share, and leave a review on Apple Podcasts. It helps more people find the show and start reclaiming their own narratives around desire.

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When a patient talks about their sexual dysfunction, I always ask: what's going on with the person they're having sex with? You’d be surprised how many providers don’t.

Most people don’t think to ask what’s happening on both sides of a sexual relationship. But sexual dysfunction doesn’t happen in a vacuum—it’s a two-way street. In this episode, I’m joined by Dr. Jessica Yih, a urologist who treats both men and women, and we get real about the overlap of issues that show up in the bedroom.

We dive into Peyronie’s disease and why it’s been overlooked for so long, how injections can break down plaques, and why those curves aren’t just uncomfortable—they can lead to serious problems for both partners. We also break down erectile dysfunction beyond the “just pop a blue pill” myth. Spoiler: Viagra doesn’t work for everyone.

Jessica brings a powerful perspective to the conversation, especially around what it’s like treating both members of a couple, sometimes in back-to-back appointments. She’s also helping train the next generation of sexual health urologists through her fellowship at UC Irvine.

Sex is more than individual dysfunction—it’s communication, treatment access, aging, and understanding both bodies in the room. If you’re a provider, a patient, or just curious about how these dynamics work together, this episode is for you.

Highlights:

• The truth about Peyronie’s disease, painful sex, and treatment options
• Why Viagra isn’t a one-size-fits-all fix for erectile dysfunction
• How injectable medications and implants are changing the game
• Dyadic sexuality and the importance of treating both partners
• Jessica Yih’s unique path to sexual medicine and her work training new fellows

If this episode got you thinking, please hit that follow button, leave a comment, and give us a review on Apple Podcasts or Spotify. Your support helps more people find the info they’ve been missing.

Dr. Yih’s Bio:

Dr. Jessica Yih is a urologist specializing in both male and female sexual health and male infertility. She currently serves as Director of Women’s Sexual Health and Male Infertility and Assistant Professor at UC Irvine. Her clinical focus includes menopause care, vestibulodynia, arousal and orgasm disorders, erectile dysfunction, and oncofertility.

Dr. Yih is active in research, surgical education, and advocacy, particularly in advancing care for women’s sexual health. She contributes to several professional societies including SMSNA, ISSWSH, SMRU, AUA, and SWIU.

She holds degrees in brain sciences, medical sciences, mental health, and healthcare management, and completed her M.D. at Wayne State, urology residency at Case Western, and fellowship at San Diego Sexual Medicine.

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Why are so many women still faking orgasms—and blaming themselves for sex that doesn’t feel good?

I can't even begin to tell you how many women come into my office thinking they’re broken—because sex isn’t working for them the way it “should.” They’re doing all the right things, checking all the boxes, and still feeling disconnected, dry, resentful, or just straight-up bored in the bedroom. But here's the thing: it's not their fault, and they’re definitely not alone.

In this episode, I’m talking with Maria, a total powerhouse in sexual medicine and menopause care. We go deep into the systemic blind spots in medical training, the cultural shame around female pleasure, and how most of us were never even taught how to understand our own bodies. From the bedroom gap to vibrator prescriptions, we’re covering it all—honestly, unfiltered, and with the kind of compassion that’s long overdue.

Maria shares how her own clinical journey shifted when she realized how many women were being misdiagnosed or dismissed—especially when it came to menopause and sexual health. She’s on a mission to close the gendered healthcare gap, and she’s not waiting around for the system to catch up. We also dig into the everyday stuff: how screens are killing sex, why novelty matters, and how to actually start advocating for the sex life you want.

This is one of those conversations that’ll make you laugh, nod, and maybe even rethink your nightstand drawer. And yes, we talk about lubes, vibrators, and why your bedroom deserves better vibes (and better lighting).

• The origin of The Bedroom Gap and how it's damaging women's relationships
• Why Maria believes medical education is failing women—especially in menopause
• The orgasm gap, mercy sex, and how women are taught to prioritize male pleasure
• The cultural baggage that still surrounds self-pleasure and masturbation
• How to reframe your relationship with lube, sex toys, and your own body

If you loved this episode, don’t forget to like, subscribe, and leave a comment wherever you’re listening. To keep growing the show we would love it if you would leave a review on Apple Podcasts It helps more women find these real, necessary conversations—and that means we all win.

Dr. Maria Sophocles bio:

Maria has been a practicing gynecologist for 29 years and is an internationally respected expert in menopause and female sexual function.

She is the founder of Women's Healthcare of Princeton, a progressive gynecology practice serving over 30,000 women in the U.S. To meet the needs of international and remote U.S. patients, in 2024  she launched The Thinking Woman, a virtual consultation practice.

She completed a BA in English with honors and distinction from Duke University, attended medical School at Jefferson Medical College and completed her residency at Johns Hopkins Hospital’s Greater Baltimore Medical Center. 

She is board certified in ob/gyn, a certified menopause practitioner, and has been named a fellow to national societies (ISSVD and ISSWSH) for her contributions to gynecology.

As one of the first U.S. clinicians to recognize the need for a non-estrogen option to treat vaginal atrophy, in 2015 she pioneered the use of Co2 Laser  in the U.S.; she has taught clinicians this technology on five continents.

A passionate advocate for reproductive freedom and contraceptive access, she fought for seven years alongside Senator Shirley Turner to achieve passage of New Jersey Bill S275, a part of the historic Freedom of Reproductive Choice Act which became law in 2023.

Appalled by the pervasiveness of the gendered healthcare gap, she is developing a Women’s Health clinic in rural Kenya.

Her TED talk “What Happens to Sex in Midlife” has garnered nearly a million views and her forthcoming book, The Bedroom Gap will be released in late 2025. 

She is currently at work on a documentary about Sex, Menopause and Gender Equality called HOT!. She is married with four children. 

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Maria's Ted Talk

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What if your pain, irritation, or sexual discomfort was being dismissed because no one ever taught your doctor how to look for the real cause?

There’s a reason vulvar conditions like lichen sclerosus are often missed or misdiagnosed—and it’s not because they’re rare. It's because most doctors aren't trained to recognize the signs. In this episode, I’m joined by Dr. Jill Krapf, a dedicated gynecologist and vulvar skin expert, to unpack the truth about vulvar dermatoses, why it takes so long to get diagnosed, and what can be done when scarring, pain, and sexual dysfunction start taking over your life.

We don’t just skim the surface—we go deep into the subtle (and not-so-subtle) symptoms, the stories of people who were told nothing was wrong when something clearly was, and what really works when managing chronic vulvar skin conditions. Jill also shares insights about how women of color are even more likely to be overlooked and misdiagnosed because of gaps in training and representation in medical education.

If you’ve ever been told “it’s just in your head,” or if you’ve silently dealt with vulvar discomfort, pain with sex, or itching that won’t go away—this episode is a must. There is real hope and effective care available. You just need to know where to look—and what to ask.

💡 Highlights:

• Why vulvar conditions are so often missed in both OB-GYN and dermatology settings
• The different types of lichen (and why not all itching is the same)
• Scarring, fissures, and sexual pain: when to ask about surgical options
• How patients of color face even more barriers to diagnosis and care
• What to know about emerging treatments like JAK inhibitors and lasers

Dr. Krapf’s Bio:

Dr. Jill Krapf is a board-certified Obstetrician Gynecologist specializing in female sexual pain disorders and Director of the Center for Vulvovaginal Disorders Florida in Tampa, Florida, USA. She is active in research and has published chapters and peer-reviewed articles on vulvodynia and vulvar lichen sclerosus.

She is Associate Editor for the medical journal Sexual Medicine, as well as for the textbook Female Sexual Pain Disorders, 2 nd Edition. She is a Fellow of the International Society for the Study of Vulvovaginal Disease (ISSVD) and a Fellow and Board Member of the International Society for the Study of Women’s Sexual Health (ISSWSH), serving on the Education Committee and the Social Media Committee. Dr. Krapf is a co-author on the trade book “When Sex Hurts: Understanding and Healing Pelvic Pain.” She shares educational content on social media @jillkrapfmd.

If this episode helped you feel seen or gave you language to advocate for your health, don’t keep it to yourself. Like, comment, and share this episode with someone who needs it. And don’t forget to subscribe for more unfiltered conversations on women’s health.

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