In this episode, we review ascending aorta dilation and ascending aorta aneurysm, including the key syndromes associated. What is cystic medial degeneration? Which diseases cause dilation of the aortic root versus dilation of the ascending aorta? In which diseases is ascending aorta dilation defined by diameter (cm) versus body surface area-indexed diameter (cm/m^2) versus aortic root cross sectional area to height ratio (cm^2/m)? In which diseases is the cutoff for surgical intervention ≥5.5cm, ≥5.0cm, ≥4.5cm, and ≥4.0cm? What is the definition of rapid growth in 1 year and in 2 years? Among the sinotubular junction, sinuses of Valsalva, aorto-ventricular junction, aortic annulus, and left ventricular outflow tract, which lengths should be measured leading edge to leading edge, and which should be measured inner edge to inner edge on echocardiography? Which should be measured in end-diastole and which should be measured in mid-systole? In what situation is echo sufficient for monitoring ascending aorta dilation instead of CT/MRI? How often should you perform serial imaging for monitoring of ascending aorta dilation that has not yet met the cutoff for surgical intervention? What does medical management consist of? What are manifestations of Marfan's syndrome other than aortic root dilation, and how are they similar or different than the manifestations of Ehlers-Danlos' syndrome? What does bifid uvula suggest? Which syndrome presents with foot pain, multiple food allergies, and bifid uvula? Tune in for answers to these questions.