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In this episode, we discuss three findings that have made the rounds in the geroscience and healthspan spaces in recent months. They relate to three universally-relevant topics: pregnancy, exercise, and diet.

The first study suggested that women who have been pregnant at least once age faster than women who had never been pregnant, controlling for social, environmental, and genetic variation and measuring aging rate via six epigenetic clocks.

The second study found a connection between workout timing and cardiovascular disease, microvascular disease, and all-cause mortality risk in adults with obesity. Evening workouts appeared to lead to the greatest morbidity and mortality benefits.

The third study, which researchers presented at a recent American Heart Association meeting, demonstrated a positive relationship between time-restricted eating—that is, eating all daily meals in a short time window rather than throughout the day—and risk of dying from heart disease.

It's been an interesting time for geroscience-related findings. Matt and Nick chat about the three studies, discussing their potential limitations, possible mechanisms underlying the observed longevity effects, and further work that would provide greater depth to our understanding of healthspan and longevity.

Producers: Tara Mei, Nicholas Arapis

Video Editor: Jacob Keliikoa

DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.

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Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.

On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!