JAMA Statistical Editor Roger Lewis, MD, PhD, discusses Use of Run-in Periods in Randomized Trials with Jane M. Armitage, MBBS.

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• Short- and Long-term Effects of a Mobile Phone App in Conjunction With Brief In-Person Counseling on Physical Activity Among Physically Inactive Women: The mPED Randomized Clinical Trial

JAMA Statistical Editor Roger Lewis, MD, discusses Regression Discontinuity Design with Matthew L. Maciejewski, PhD.

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• Using Instrumental Variables to Address Bias From Unobserved Confounders

JAMA Statistical Editor Roger Lewis, MD, discusses Case-Control Studies: Using "Real-world" Evidence to Assess Association, With Dr Irony.

Roger J. Lewis, MD, PhD, discusses Equipoise in Research—Integrating Ethics and Science in Human Research with Alex John London, PhD

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Equipoise in Research—Integrating Ethics and Science in Human Research

Roger J. Lewis, MD, PhD, discusses Bayesian Analysis: Using Prior Information to Interpret the Results of Clinical Trials with Melanie Quintana, PhD

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• Effect of Therapeutic Hypothermia Initiated After 6 Hours of Age on Death or Disability Among Newborns With Hypoxic-Ischemic Encephalopathy: A Randomized Clinical Trial
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Cost-effectiveness analysis defines trade-offs between costs, harms, and benefits of alternative treatments and combines them into a single metric, the incremental cost-effectiveness ratio (ICER), that can inform decisions about which interventions to recommend when limited resources are available. Gillian Sanders-Schmidler, PhD, professor of population health sciences and medicine at Duke University, explains the method in terms clinicians can understand.

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• Cost-effectiveness Analysis for Clinicians

JAMA Deputy Editor Edward Livingston, MD, discusses "Multiple Comparison Procedures" with Dr. Jing Cao, PhD

Logistic regression is one of the most commonly used statistical analytic tools in the medical literature. William Meurer, MD, from the University of Michigan, and Juliana Tolles, MD, from UCLA, discuss a JAMA Guide to Statistics and Methods article they wrote entitled "Logistic Regression Diagnostics: Understanding How Well a Model Predicts Outcomes."

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Logistic Regression

Roger J. Lewis, MD, PhD, discusses Randomization in Clinical Trials from the JAMA Guide to Statistics and Methods

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Randomization in Clinical Trials

Cluster randomized trials are performed when an intervention must be delivered to a group of patients like when testing new nursing protocols on award or different means for cleaning beds on a ward. One type of cluster trials is called a stepped-wedge where every cluster in the study ultimately undergoes the intervention. How this works it is explained by Susan Ellenberg, PhD, from the Department of Biostatistics, Epidemiology, and Informatics at the University of Pennsylvania School of Medicine.

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The Stepped-Wedge Clinical Trial