Cost-effectiveness analysis defines trade-offs between costs, harms, and benefits of alternative treatments and combines them into a single metric, the incremental cost-effectiveness ratio (ICER), that can inform decisions about which interventions to recommend when limited resources are available. Gillian Sanders-Schmidler, PhD, professor of population health sciences and medicine at Duke University, explains the method in terms clinicians can understand.

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• Cost-effectiveness Analysis for Clinicians

JAMA Deputy Editor Edward Livingston, MD, discusses "Multiple Comparison Procedures" with Dr. Jing Cao, PhD

Logistic regression is one of the most commonly used statistical analytic tools in the medical literature. William Meurer, MD, from the University of Michigan, and Juliana Tolles, MD, from UCLA, discuss a JAMA Guide to Statistics and Methods article they wrote entitled "Logistic Regression Diagnostics: Understanding How Well a Model Predicts Outcomes."

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Logistic Regression

Roger J. Lewis, MD, PhD, discusses Randomization in Clinical Trials from the JAMA Guide to Statistics and Methods

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Randomization in Clinical Trials

Cluster randomized trials are performed when an intervention must be delivered to a group of patients like when testing new nursing protocols on award or different means for cleaning beds on a ward. One type of cluster trials is called a stepped-wedge where every cluster in the study ultimately undergoes the intervention. How this works it is explained by Susan Ellenberg, PhD, from the Department of Biostatistics, Epidemiology, and Informatics at the University of Pennsylvania School of Medicine.

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The Stepped-Wedge Clinical Trial

JAMA Deputy Editor Edward Livingston, MD, discusses Minimal Clinically Important Difference: Defining What Really Matters to Patients with Anna E. McGlothlin, PhD

One of the most common causes for problems we see in manuscripts at JAMA is an inappropriately calculated study sample size. This seemingly mysterious process is explained by Lynne Stokes, PhD, professor of Statistical Science at Southern Methodist University in Dallas, Texas.

JAMA Deputy Editor Edward Livingston, MD, discusses Pragmatic Trials: Practical Answers to "Real-world" Questions with Harold C. Sox, MD, of PCORI

JAMA Deputy Editor Edward Livingston, MD, discusses "Cluster Randomized Trials: Evaluating Treatments Applied to Groups" with William J. Meurer, MD, MS

Ed Livingston, MD, FACS, AGAF, discusses Noninferiority Trials: Is a New Treatment Almost as Effective as Another? with Amy Kaji, MD, PhD