Psychedelics are usually known for many things: making people see cool fractal patterns, shaping 60s music culture, healing trauma. Neuroscientists use them to study the brain, ravers love to dance on them, shamans take them to communicate with spirits (or so they say).

But psychedelics also help against one of the world's most painful conditions — cluster headaches. Cluster headaches usually strike on one side of the head, typically around the eye and temple, and last between 15 minutes and 3 hours, often generating intense and disabling pain. They tend to cluster in an 8-10 week period every year, during which patients get multiple attacks per day — hence the name. About 1 in every 2000 people at any given point suffers from this condition.

One psychedelic in particular, DMT, aborts a cluster headache near-instantly — when vaporised, it enters the bloodstream in seconds. DMT also works in “sub-psychonautic” doses — doses that cause little-to-no perceptual distortions. Other psychedelics, like LSD and psilocybin, are also effective, but they have to be taken orally and so they work on a scale of 30+ minutes.

This post is about the condition, using psychedelics to treat it, and ClusterFree — a new [...]

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Outline:

(01:49) Cluster headaches are really fucking bad

(03:07) Two quotes by patients (from Rossi et al, 2018)

(04:40) The problem with measuring pain

(06:20) The McGill Pain Questionnaire

(07:39) The 0-10 Numeric Rating Scale

(09:14) The heavy tails of pain (and pleasure)

(10:58) An intuition for Weber's law for pain

(13:04) Why adequately quantifying pain matters

(15:06) Treating cluster headaches

(16:04) Psychedelics are the most effective treatment

(18:51) Why psychedelics help with cluster headaches

(22:39) ClusterFree

(25:03) You can help solve this medico-legal crisis

(25:18) Sign a global letter

(26:11) Donate

(27:06) Hell must be destroyed

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First published:
February 7th, 2026

Source:
https://www.lesswrong.com/posts/dnJauoyRTWXgN9wxb/near-instantly-aborting-the-worst-pain-imaginable-with

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When economists think and write about the post-AGI world, they often rely on the implicit assumption that parameters may change, but fundamentally, structurally, not much happens. And if it does, it's maybe one or two empirical facts, but nothing too fundamental.

This mostly worked for all sorts of other technologies, where technologists would predict society to be radically transformed e.g. by everyone having most of humanity's knowledge available for free all the time, or everyone having an ability to instantly communicate with almost anyone else. [1]

But it will not work for AGI, and as a result, most of the econ modelling of the post-AGI world is irrelevant or actively misleading [2], making people who rely on it more confused than if they just thought “this is hard to think about so I don’t know”.

Econ reasoning from high level perspective

Econ reasoning is trying to do something like projecting the extremely high dimensional reality into something like 10 real numbers and a few differential equations. All the hard cognitive work is in the projection. Solving a bunch of differential equations impresses the general audience, and historically may have worked as some sort of proof of [...]



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Outline:

(00:57) Econ reasoning from high level perspective

(02:51) Econ reasoning applied to post-AGI situations

The original text contained 10 footnotes which were omitted from this narration.

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First published:
February 4th, 2026

Source:
https://www.lesswrong.com/posts/fL7g3fuMQLssbHd6Y/post-agi-economics-as-if-nothing-ever-happens

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The recent book “If Anyone Builds It Everyone Dies” (September 2025) by Eliezer Yudkowsky and Nate Soares argues that creating superintelligent AI in the near future would almost certainly cause human extinction:

If any company or group, anywhere on the planet, builds an artificial superintelligence using anything remotely like current techniques, based on anything remotely like the present understanding of AI, then everyone, everywhere on Earth, will die.

The goal of this post is to summarize and evaluate the book's key arguments and the main counterarguments critics have made against them.

Although several other book reviews have already been written I found many of them unsatisfying because a lot of them are written by journalists who have the goal of writing an entertaining piece and only lightly cover the core arguments, or don’t seem understand them properly, and instead resort to weak arguments like straw-manning, ad hominem attacks or criticizing the style of the book.

So my goal is to write a book review that has the following properties:

• Written by someone who has read a substantial amount of AI alignment and LessWrong content and won’t make AI alignment beginner mistakes or misunderstandings (e.g. not knowing about the [...]

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Outline:

(07:43) Background arguments to the key claim

(09:21) The key claim: ASI alignment is extremely difficult to solve

(12:52) 1. Human values are a very specific, fragile, and tiny space of all possible goals

(15:25) 2. Current methods used to train goals into AIs are imprecise and unreliable

(16:42) The inner alignment problem

(17:25) Inner alignment introduction

(19:03) Inner misalignment evolution analogy

(21:03) Real examples of inner misalignment

(22:23) Inner misalignment explanation

(25:05) ASI misalignment example

(27:40) 3. The ASI alignment problem is hard because it has the properties of hard engineering challenges

(28:10) Space probes

(29:09) Nuclear reactors

(30:18) Computer security

(30:35) Counterarguments to the book

(30:46) Arguments that the books arguments are unfalsifiable

(33:19) Arguments against the evolution analogy

(37:38) Arguments against counting arguments

(40:16) Arguments based on the aligned behavior of modern LLMs

(43:16) Arguments against engineering analogies to AI alignment

(45:05) Three counterarguments to the books three core arguments

(46:43) Conclusion

(49:23) Appendix

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First published:
January 24th, 2026

Source:
https://www.lesswrong.com/posts/qFzWTTxW37mqnE6CA/iabied-book-review-core-arguments-and-counterarguments

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Author's note: this is somewhat more rushed than ideal, but I think getting this out sooner is pretty important. Ideally, it would be a bit less snarky.

Anthropic[1] recently published a new piece of research: The Hot Mess of AI: How Does Misalignment Scale with Model Intelligence and Task Complexity? (arXiv, Twitter thread).

I have some complaints about both the paper and the accompanying blog post.

tl;dr

• The paper's abstract says that "in several settings, larger, more capable models are more incoherent than smaller models", but in most settings they are more coherent. This emphasis is even more exaggerated in the blog post and Twitter thread. I think this is pretty misleading.
• The paper's technical definition of "incoherence" is uninteresting[2] and the framing of the paper, blog post, and Twitter thread equivocate with the more normal English-language definition of the term, which is extremely misleading.
• Section 5 of the paper (and to a larger extent the blog post and Twitter) attempt to draw conclusions about future alignment difficulties that are unjustified by the experiment results, and would be unjustified even if the experiment results pointed in the other direction.
• The blog post is substantially LLM-written. I think this [...]

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Outline:

(00:39) tl;dr

(01:42) Paper

(06:25) Blog

The original text contained 3 footnotes which were omitted from this narration.

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First published:
February 4th, 2026

Source:
https://www.lesswrong.com/posts/ceEgAEXcL7cC2Ddiy/anthropic-s-hot-mess-paper-overstates-its-case-and-the-blog

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tl;dr: You can pledge to join a big protest to ban AGI research at ifanyonebuildsit.com/march, which only triggers if 100,000 people sign up.

The If Anyone Builds It website includes a March page, wherein you can pledge to march in Washington DC, demanding an international treaty to stop AGI research if 100,000 people in total also pledge.

I designed the March page (although am not otherwise involved with March decisionmaking), and want to pitch people on signing up for the "March Kickstarter."

It's not obvious that small protests do anything, or are worth the effort. But, I think 100,000 people marching in DC would be quite valuable because it showcases "AI x-risk is not a fringe concern. If you speak out about it, you are not being a lonely dissident, you are representing a substantial mass of people."

The current version of the March page is designed around the principle that "conditional kickstarters are cheap." MIRI might later decide to push hard on the March, and maybe then someone will bid for people to come who are on the fence.

For now, I mostly wanted to say: if you're the sort of person who would fairly obviously come to [...]

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Outline:

(01:54) Probably expect a design/slogan reroll

(03:10) FAQ

(03:13) Whats the goal of the Dont Build It march?

(03:24) Why?

(03:55) Why do you think that?

(04:22) Why does the pledge only take effect if 100,000 people pledge to march?

(04:56) What do you mean by international treaty?

(06:00) How much notice will there be for the actual march?

(06:14) What if I dont want to commit to marching in D.C. yet?

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First published:
February 2nd, 2026

Source:
https://www.lesswrong.com/posts/HnwDWxRPzRrBfJSBD/conditional-kickstarter-for-the-don-t-build-it-march

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A low-effort guide I dashed off in less than an hour, because I got riled up.

1. Try not to hire a team. Try pretty hard at this.
   1. Try to find a more efficient way to solve your problem that requires less labor – a smaller-footprint solution.
   2. Try to hire contractors to do specific parts that they’re really good at, and who have a well-defined interface. Your relationship to these contractors will mostly be transactional and temporary.
   3. If you must, try hiring just one person, a very smart, capable, and trustworthy generalist, who finds and supports the contractors, so all you have to do is manage the problem-and-solution part of the interface with the contractors. You will need to spend quite a bit of time making sure this lieutenant understands what you’re doing and why, so be very choosy not just about their capabilities but about how well you work together, how easily you can make yourself understood, etc.
2. If that fails, hire the smallest team that you can. Small is good because:
   1. Managing more people is more work.
      1. The relationship between number of people and management overhead is roughly O(n) but unevenly distributed; some people [...]

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First published:
January 29th, 2026

Source:
https://www.lesswrong.com/posts/cojSyfxfqfm4kpCbk/how-to-hire-a-team

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The Possessed Machines is one of the most important AI microsites. It was published anonymously by an ex- lab employee, and does not seem to have spread very far, likely at least partly due to this anonymity (e.g. there is no LessWrong discussion at the time I'm posting this). This post is my attempt to fix that.

I do not agree with everything in the piece, but I think cultural critiques of the "AGI uniparty" are vastly undersupplied and incredibly important in modeling & fixing the current trajectory.

The piece is a long but worthwhile analysis of some of the cultural and psychological failures of the AGI industry. The frame is Dostoevsky's Demons (alternatively translated The Possessed), a novel about ruin in a small provincial town. The author argues it's best read as a detailed description of earnest people causing a catastrophe by following tracks laid down by the surrounding culture that have gotten corrupted:

What I know is that Dostoevsky, looking at his own time, saw something true about how intelligent societies destroy themselves. He saw that the destruction comes from the best as well as the worst, from the idealists as well as the cynics, from the [...]

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First published:
January 25th, 2026

Source:
https://www.lesswrong.com/posts/ppBHrfY4bA6J7pkpS/the-possessed-machines-summary

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Papal election of 1492 For over a decade, Ada Palmer, a history professor at University of Chicago (and a science-fiction writer!), struggled to teach Machiavelli. “I kept changing my approach, trying new things: which texts, what combinations, expanding how many class sessions he got…” The problem, she explains, is that “Machiavelli doesn’t unpack his contemporary examples, he assumes that you lived through it and know, so sometimes he just says things like: Some princes don’t have to work to maintain their power, like the Duke of Ferrara, period end of chapter. He doesn’t explain, so modern readers can’t get it.”

Palmer's solution was to make her students live through the run-up to the Italian Wars themselves. Her current method involves a three-week simulation of the 1492 papal election, a massive undertaking with sixty students playing historical figures, each receiving over twenty pages of unique character material, supported by twenty chroniclers and seventy volunteers. After this almost month-long pedagogical marathon, a week of analysis, and reading Machiavelli's letters, students finally encounter The Prince. By then they know the context intimately. When Machiavelli mentions the Duke of Ferrara maintaining power effortlessly, Palmer's students react viscerally. They remember Alfonso and Ippolito d’Este as [...]

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First published:
January 25th, 2026

Source:
https://www.lesswrong.com/posts/doADJmyy6Yhp47SJ2/ada-palmer-inventing-the-renaissance

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This is a partial follow-up to AISLE discovered three new OpenSSL vulnerabilities from October 2025.

TL;DR: OpenSSL is among the most scrutinized and audited cryptographic libraries on the planet, underpinning encryption for most of the internet. They just announced 12 new zero-day vulnerabilities (meaning previously unknown to maintainers at time of disclosure). We at AISLE discovered all 12 using our AI system. This is a historically unusual count and the first real-world demonstration of AI-based cybersecurity at this scale. Meanwhile, curl just cancelled its bug bounty program due to a flood of AI-generated spam, even as we reported 5 genuine CVEs to them. AI is simultaneously collapsing the median ("slop") and raising the ceiling (real zero-days in critical infrastructure).

Background

We at AISLE have been building an automated AI system for deep cybersecurity discovery and remediation, sometimes operating in bug bounties under the pseudonym Giant Anteater. Our goal was to turn what used to be an elite, artisanal hacker craft into a repeatable industrial process. We do this to secure the software infrastructure of human civilization before strong AI systems become ubiquitous. Prosaically, we want to make sure we don't get hacked into oblivion the moment they come online.

[...]

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Outline:

(01:05) Background

(02:56) Fall 2025: Our first OpenSSL results

(05:59) January 2026: 12 out of 12 new vulnerabilities

(07:28) HIGH severity (1):

(08:01) MODERATE severity (1):

(08:24) LOW severity (10):

(13:10) Broader impact: curl

(17:06) The era of AI cybersecurity is here for good

(18:40) Future outlook

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First published:
January 27th, 2026

Source:
https://www.lesswrong.com/posts/7aJwgbMEiKq5egQbd/ai-found-12-of-12-openssl-zero-days-while-curl-cancelled-its

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Dario Amodei, CEO of Anthropic, has written a new essay on his thoughts on AI risk of various shapes. It seems worth reading, even if just for understanding what Anthropic is likely to do in the future.

Confronting and Overcoming the Risks of Powerful AI

There is a scene in the movie version of Carl Sagan's book Contact where the main character, an astronomer who has detected the first radio signal from an alien civilization, is being considered for the role of humanity's representative to meet the aliens. The international panel interviewing her asks, “If you could ask [the aliens] just one question, what would it be?” Her reply is: “I’d ask them, ‘How did you do it? How did you evolve, how did you survive this technological adolescence without destroying yourself?” When I think about where humanity is now with AI—about what we’re on the cusp of—my mind keeps going back to that scene, because the question is so apt for our current situation, and I wish we had the aliens’ answer to guide us. I believe we are entering a rite of passage, both turbulent and inevitable, which will test who we are as a species. Humanity [...]

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Outline:

(00:24) Confronting and Overcoming the Risks of Powerful AI

(15:19) 1. I'm sorry, Dave

(15:23) Autonomy risks

(28:53) Defenses

(41:17) 2. A surprising and terrible empowerment

(41:22) Misuse for destruction

(54:50) Defenses

(01:00:25) 3. The odious apparatus

(01:00:30) Misuse for seizing power

(01:13:08) Defenses

(01:19:48) 4. Player piano

(01:19:51) Economic disruption

(01:21:18) Labor market disruption

(01:33:43) Defenses

(01:37:43) Economic concentration of power

(01:40:49) Defenses

(01:43:13) 5. Black seas of infinity

(01:43:17) Indirect effects

(01:47:29) Humanity's test

(01:53:58) Footnotes

The original text contained 92 footnotes which were omitted from this narration.

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First published:
January 26th, 2026

Source:
https://www.lesswrong.com/posts/kzPQohJakutbtFPcf/dario-amodei-the-adolescence-of-technology

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