Longevity Roadmap

Buck and Alan Viglione, MD discuss the Cardio IQ® report in detail and battle it out to see has the best numbers in this 2 part episode. This is Part 2. If you missed Part 1, check out episode 20.

• 0:01:16 - Metabolic Markers and Cardiovascular Risk
• 0:01:55 - Framingham Risk
• 0:06:08 - Hemoglobin A1C
• 0:08:00 - C-peptide
• 0:09:07 - Homocysteine and the methylation cycle
• 0:11:50 - Methyl Protect®
• 0:13:46 - Why is Vitamin D important?
• 0:21:34 - APOE Genotype
• 0:24:35 - Alzheimer's Disease Risk
• 0:28:57 - Colchicine Study

Scary news last week when Bronny James, the 18 year old son of Lebron and Savannah James collapsed during a workout at USC. It has been reported that James suffered a cardiac arrest. In September 2022 another seemingly healthy and fit USC basketball player, Vince Iwuchukwu also suffered cardiac arrest.

Thankfully USC was prepared and in both cases they were able to get these young athlete's hearts beating again. Buck discusses why and how it happens.

• 0:00:11 - Bronny James' cardiac arrest
• 0:00:53 - What is cardiac arrest?
• 0:01:23 - Arrhythmias or abnormal beating of the heart
• 0:01:48 - Myocardial Infarction or heart attack
• 0:02:42 - Hypertrophic Cardiomyopathy
• 0:04:11 - Early detection is key

Buck and Alan Viglione, MD discuss the Cardio IQ® report in detail and battle it out to see has the best numbers in this 2 part episode. Part 2 will drop as Episode 22.

• 0:01:31 - What exactly is a Cardio IQ?
• 0:03:15 - the cost of Cardio IQ
• 0:05:18 -Lipid panel, Total Cholesterol, HDL, Triglycerides, LDL Cholesterol
• 0:08:29 - HDL the so-called good cholesterol
• 0:13:55 - Lipoproteins
• 0:15:42 - LDL Particle Number
• 0:22:46 - Apolipoproteins
• 0:25:40 - Apolyte protein tag
• 0:27:48 - Apolipoprotein B or apoB
• 0:28:31 - Lipoprotein(a) or Lp(a)
• 0:31:41 - Statins: Crestor and Livalo
• 0:32:41 - How do Statins work?
• 0:33:11 - Repatha
• 0:36:58 - Inflammation and Atherogenesis
• 0:39:39 - High-sensitivity C-reactive protein (hsCRP)
• 0:40:43 - Lp-PLA2 activity
• 0:41:43 - Oxidative LDL
• 0:42:04 - Myeloperoxidase enzyme
• 0:45:07 - F2-isoprostanes as a marker of risk

In this episode Buck discusses snoring and sleep apnea and why they should be taken seriously.

• 0:01:17 - Snoring And Sleep Apnea
• 0:01:45 - Up To 20% Of The Population Has Clinically Relevant Sleep Apnea
• 0:02:52 - Central Sleep Apnea
• 0:03:12 - Obstructive Sleep Apnea
• 0:03:34 - Sleep Apnea Is The Enemy Deep Sleep
• 0:03:59 - Increased Risk Of Diseases Associated With Sleep Apnea
• 0:05:32 - Sleep Apnea Screening
• 0:05:56 - Epworth Sleepiness Scale https://epworthsleepinessscale.com/about-the-ess/
• 0:06:16 - Apnea/Hypopnea Index
• 0:06:44 - How to Treat Sleep Apnea
• 0:07:10 - CPAP Machine
• 0:07:32 - Mandibular Advancement Device
• 0:08:53 - Uvulopalatopharyngoplasty (UPPP)

Buck talks with GRAIL President Josh Ofman, MD, MSHS, about their groundbreaking Multi-cancer early detection (MCED) technology and it's promise as a significant new tool in the war on cancer.

• 0:00:00 - Advancements in Cancer Detection Technology
• 0:00:35 - GRAIL Galleri test
• 0:02:11 - About Dr. Josh Ofman
• 0:05:14 - Cancer really is a disease of the genome
• 0:12:35 - Various guidelines for early detection of certain cancers
• 0:16:45 - Cancer Detection in Blood Biology
• 0:19:03 - Cell-Free DNA
• 0:23:38 - How many cancers is the GRAIL Galleri test able to detect?
• 0:27:10 - How accurate is the GRAIL Galleri test?
• 0:31:49 - Limitations of the GRAIL Galleri test
• 0:36:18 - Why would oncologists be against this test?
• 0:40:57 - What happens after one gets a a "cancer signal detected" result?
• 0:45:13 - GRAIL Galleri test's Impact on Cancer Screening
• 0:48:42 - The cost of the GRAIL Galleri test

In this Sapio Short Buck discusses the news last week that the World Health Organization (WHO) has declared the artificial sweetener Aspartame a "a possible carcinogen". So what does this classification mean for you and how worried should you be?

• 0:00:13 - World Health Organization classified aspartame as a possible carcinogenic substance
• 0:02:03 - Group 2B - the possibly carcinogenic to humans category
• 0:03:18 - WHO concedes that the upper limit for safe daily consumption of aspartame is equivalent to drinking 9 to 14 cans of Diet Coke per day for the average 150 lb. person.
• 0:04:10 - Consider another sweetener like Splenda or Stevia

In this episode, Alan Viglione, MD joins Buck to answer some of our audience questions.

• 0:01:08 - How To Prevent The Dawn Phenomenon Or Rise Of Sugar Levels During Sleep Or Early Morning
• 0:04:44 - Hemoglobin A1C
• 0:08:00 - What Is Gluconeogenesis?
• 0:14:24 - Managing Dawn Phenomenon
• 0:18:04 - A Question About Geroprotectant Supplements
• 0:19:37 - Nicotinamide Riboside As A Precursor to NAD+
• 0:26:02 - What Is A Senolytic?
• 0:29:29 - Benefits Of Senolytics
• 0:30:27 - Promising Potential Of Quercetin
• 0:32:30 - Genova NutrEval Test
• 0:34:11 - The MTHFR Gene Mutation
• 0:41:56 - A Question About The Kirk Cousins Era With The Minnesota Vikings
• 0:44:10 - Cholesterol Management For Women
• 0:54:27 - A Question About Helpful Daily Supplements And How To Tell Which Supplement Companies Are The True Good Guys
• 0:59:12 - Vitamin D Deficiency And Supplementation
• 1:01:31 - Discussion On Vitamins, Supplements, And Sleep

In this episode Buck continues his conversation with Rob Hamilton MD from Prestige Regenerative Medicine - this time discussing Female Hormone Replacement. When to get it, why to get it, what to expect and how it plays into Longevity and making you feel optimal.

• 0:01:14 - Overview Of Some Of The Hormonal Issues That Women Go Through Throughout Their Life
• 0:03:33 - Average Age When Women Experience Menopause And Perimenopause
• 0:06:51 - Pharmaceuticals Developed To Address Menopausal Symptoms In Women: Premarin And Provera
• 0:13:47 - Benefits Of Hormone Replacement Therapy
• 0:17:12 - Understanding Perimenopause And Testosterone Decline In Women
• 0:22:55 - The Secret Female Hormone: How Testosterone Replacement Can Change Your Life By Dr. Kathy C. Maupin
• 0:23:57 - Hormone Pellet Replacement For Women
• 0:25:02 - Side Effects Of Testosterone Replacement In Women
• 0:27:09 - Benefits Of Testosterone Replacement In Women
• 0:30:57 - Acoustic Wave Therapy For Women

Buck discusses Male Hormone Replacement with Rob Hamilton, MD from Prestige Regenerative Medicine. When to get it, why to get it, what to expect and how it plays into Longevity and making you feel optimal. Human Growth Hormone is also discussed in this hour-long discussion.

• 0:00:12 - Rob Hamilton's Background
• 0:04:44 - What Happens With These Kinds Of Male Sex Hormones Over Time?
• 0:05:46 - Declining Testosterone Levels In Men Aged 35 To 40
• 0:09:23 - Testosterone Is An Anabolic Hormone
• 0:11:17 - Testosterone Is An Important Hormone To Maintain Health.
• 0:18:37 - Replacing Testosterone Even If You Feel Like There's Nothing Wrong With You
• 0:19:50 - Options For Increasing Testosterone Levels
• 0:20:28 - Tongkat Ali, Ashwagandha, And Other Supplements For Increasing Testosterone Levels
• 0:27:55 - Using Clomifene To Increase Testosterone Levels
• 0:29:20 - How Much Variability On A Day-To-Day Basis Is There In Testosterone In Men?
• 0:30:53 - Options For Testosterone Replacement
• 0:32:03 - Topical Testosterone Application And Side Effects
• 0:33:13 - Injectable Testosterone
• 0:35:03 - Titrating Testosterone Pellets For Optimal Therapy
• 0:37:33 - Risks Of Testosterone Replacement Options
• 0:44:04 - Human Growth Hormones
• 0:45:59 - The Challenges Of Prescribing Human Growth Hormones
• 0:50:28 -Testosterone Is A Necessary But Not Sufficient Component Of Good Erectile Function
• 0:51:02 - Atherosclerotic Cardiovascular Disease
• 0:52:46 - Phosphodiesterase Inhibitors
• 0:51:28 - GAINSwave Shockwave Therapy
• 0:57:05 - Erectile Function And Nerve Regeneration

In part two of a two part episode Buck talks with Dr. Michael Mantz, MD about Ketamine and Psychedlics.

• 0:00:29 - What Is Psilocybin?
• 0:01:42 - The Serotonergic Effects Of Psilocybin
• 0:04:08 - Exploring The Effects Of Microdosing Psilocybin
• 0:09:16 - Microdosing And Euphoria
• 0:12:03 - Exploring Psychedelic Microdosing
• 0:15:31 - The Fadiman Protocol
• 0:17:10 - The Stamets Protocol
• 0:19:59 - Microdosing Ketamine And Serotonergic Function