Subscribe to our channel: https://www.youtube.com/@optispanIn this Q&A, Matt and Brian Kennedy cover a range of topics on caloric restriction, lifespan studies, interventions like rapamycin, and the importance of control groups in research. They critique the validity of certain longevity claims, discusses the complexities of aging mechanisms, and questions the effectiveness of supplements. The conversation also touches on dietary impacts, the role of exercise, and the significance of personalized medicine in aging research, emphasizing the need for careful interpretation of scientific data.00:00:00 - Should Matt be skeptical of the 40% life extension figure for caloric restriction?00:06:43 - Can calorie restriction be combined with other interventions like Rapamycin or Senolytics?00:11:30 - Does metformin or berberine have significant effects on longevity?00:14:51 - Is pea protein powder a good dietary choice for a complete protein?00:17:33 - What are the best ways to increase VO2 max?00:20:12 - Longevity Fads?00:22:45 - How does cold exposure affect inflammation?00:26:05 - How does NAD+ supplementation compare to NMN for longevity?00:29:11 - What role does sleep quality play in overall lifespan?00:32:00 - Can mindfulness or meditation improve biomarkers related to aging?00:35:22 - Is there evidence that probiotics can extend lifespan?00:38:45 - How does alcohol consumption affect aging and longevity?00:41:10 - What are the best supplements for improving cognitive health with age?00:45:00 - Are there specific dietary patterns proven to slow biological aging?00:48:25 - How effective is Rapamycin when started later in life?00:52:10 - Can exercise offset the negative effects of a poor diet?00:55:34 - Is there a link between gut health and lifespan?00:58:20 - What are the biggest misconceptions about anti-aging interventions?01:06:33 - Do you track fiber intake?01:07:45 - What's the common misconception about mTOR?01:09:33 - Are there ongoing studies comparing rapamycin to other mTOR inhibitors in terms of safety and effect?01:11:48 - Favorite band?01:11:52 - How can a non-scientifically trained person tell good science from bad?Producers: Tara Mei, Nicholas ArapisVideo Editor: Jacob KeliikoaDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://twitter.com/optispanpodcastTwitter: https://twitter.com/optispanTwitter: https://twitter.com/mkaeberleinLinkedin: https://www.linkedin.com/company/optispanInstagram: https://www.instagram.com/optispanpodcast/TikTok: https://www.tiktok.com/@optispanhttps://www.optispan.life/