Welcome to Menopause Research Review! Now that menopause has hit the mainstream, we’re swimming in a steady stream of studies, which is great and can also be overwhelming. So for 2025, we’re introducing a regular segment called Menopause Research Review where we break down key research as it comes out with resident reproductive endocrinologist and menopause performance specialist Dr. Carla DiGirolamo. This week we kick it off with a study published in Menopause: The range and variation in serum estradiol concentration in perimenopausal and postmenopausal women treated with transdermal estradiol in a real-world setting: a cross-sectional study. We dive into hormone testing, what it tells us (and what it doesn’t) as well as what it means (or not) to have therapeutic levels.

Carla DiGirolamo, MD, PhD, is a Double Board Certified Reproductive Endocrinologist and Obstetrician/Gynecologist specializing in infertility and menopausal medicine. She is also a Crossfit Level 1 trainer, Certified Nutrition Coach, and member of CrossFit Health. She is a MedFit Care provider and provides weekly workouts and medical updates at her Substack Athletic Aging. She is an Endocrine Consultant for Wild Health. Most recently, she has launched her own private practice specializing in helping active and high-performing women reach their performance potential from puberty through menopause. Dr. DiGirolamo is now seeing patients for virtual consultations for menopausal care and performance optimization. Visit her website www.drcarlad.com to learn more about her services and schedule an appointment.

Resources

The range and variation in serum estradiol concentration in perimenopausal and postmenopausal women treated with transdermal estradiol in a real-world setting: a cross-sectional study, Menopause 

Hormone replacement therapy (oestradiol-only preparations): can the laboratory recommend a concentration of plasma oestradiol to protect against osteoporosis?, The Association of Clinical Biochemists 

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