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Hamilton Morris discussing his documentary series on psychoactive drugs, their science, cultural impacts, and misconceptions.

Topics Discussed:

• Origins of Hamilton's Pharmacopeia: Started as a column and web series to provide honest, science-based discussions on drugs, countering 1990s media stigma.
• Drug education and media bias: Traditional scare tactics fail; honest information fosters better relationships with substances, as seen in parallels with abstinence education.
• Methamphetamine misconceptions: Often stigmatized due to class differences, not pharmacology; similar to amphetamine, with FDA-approved uses for ADHD and obesity.
• Xenon gas as an anesthetic: A noble gas inducing euphoria via NMDA antagonism; harvested from air, it's expensive but potentially ideal for medical use.
• Ketamine and dissociatives: NMDA antagonists like ketamine offer rapid antidepressant effects; experiences are dose-dependent, from alcohol-like to visionary out-of-body states.
• Ibogaine in Bwiti rituals: Used for addiction treatment in Gabon; induces logical self-reflection, challenging Western views on psychedelics and spirituality.
• Drug regulation ideals: Advocate for freedom with quality controls, like food regulations; decriminalization alone lacks purity safeguards.
• Future projects: Shifting to chemistry research on psychedelics; highlights challenges in documentary production and value of synthesis education.

*Not medical advice

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Nick talks to Peter Addy, PhD about the atypical, dissociative psychedelic, salvia. Peter is a psychotherapist and spent several years at the Yale, studying human experiences with atypical psychedelics such as Salvia divinorum. 

Nick and Peter talked about salvia, including how it works and how it differs from other psychedelics, as well as dissociative and dysphoric effects, and how his research has informed his psychotherapy practice. 

*Not medical advice.

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Nick talks to Hamilton Morris, creator of the show, "Hamilton's Pharmacopeia," about the third and final season. They discuss: the last season of his show, including the content itself and what it took to actually make it; a variety of drugs and their effects, ranging from stimulants like methamphetamine, dissociatives (e.g. ketamine), psychedelics & to various forms of DMT, ibogaine and xenon gas.

*Not medical advice.

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Jonathan Page, PhD is a botanist and entrepreneur with deep expertise in Cannabis. Nick and Jon talked about all things Cannabis science including the botany and natural history of Cannabis, the chemistry and biology of Cannabis and its psychoactive effects, and whether or not different types of Cannabis can cause different effects. Jon also shared amazing stories about transitioning from scientific research to starting, building, and selling a cannabis company, and his thoughts on what’s next for the cannabis industry. 

*Not medical advice.

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Bryan Roth, MD, PhD discusses his career studying how psychedelics and other psychoactive drugs affect the brain, the massive $27 million research effort he is leading to understand psychedelics and develop novel drugs for psychiatric disease, and the practice of zen meditation.

*Not medical advice.

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Sean B. Carroll, PhD is an award-winning biologist, author, and filmmaker. Nick and Sean discuss everything from Sean's unique career trajectory and writing process, to dinosaurs and snake venom, to COVID19, the evolution of viruses, and why comedians and scientists are kindred spirits. 

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Dr. Nichols is a professor of pharmacology at Louisiana State University. He has been studying the molecular, genetic, and behavioral effects of psychedelics for nearly 25 years and is considered one of the world’s top experts on the biological effects of psychedelics in the brain and body.

Nick spoke to Charles for almost two hours, covering a wide range of topics related to how psychedelics work. They discuss everything from how psychedelics impact the serotonin system in the brain, the similarities and differences between drugs like psilocybin and ketamine, how microdosing specific psychedelics can lead to potent anti-inflammatory effects, and much more.

*Not medical advice.

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Brian is the author of the New York Times-bestselling book, "The Immortality Key: The Secret History of the Religion With No Name." Brian is fluent in Ancient Greek, Latin, and Sanskrit, and spent over a decade putting together an incredible story about the intentional use of psychoactive plants in the ancient world, including scientific evidence for the ritual use of spiked beers and wines. 

Nick and Brian cover topics related to his book, including the use of psilocybin mushrooms in the present to treat end of life anxiety, how “Mystery Schools” in the ancient Greco-Roman world, such as Eleusis, may have utilized psychedelic beverages, the evidence for the potential widespread use of psychoactive plants in ritual settings in ancient times, and how this may have influenced early Christianity, and how psychedelic drugs may induce brain states similar to those produced in near-death experiences.

*This content is never meant to serve as medical advice.

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