Neurology® Podcast

1) Mid-life milk consumption and substantia nigra neuron density at death2) What's Trending: Interview with Dr. Ray Dorsey about new Neurology site, which will be called Innovations in Care Delivery3) Topic of the month: Neurology Today story about should there be a moratorium on human germline editingThis podcast for the Neurology Journal begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the print issue of Neurology. In the second segment Dr. Binit Shah interviews Dr. Robert Abbott about his paper on mid-life milk consumption and substantia nigra neuro density at death. Dr. Robert Gross is interviewing Dr. Ray Dorsey for our "What's Trending" feature of the week about being the section editor and curator of our new Neurology site, which will be called Innovations in Care Delivery. In the next part of the podcast Dr. Ted Burns interviews Dr. Thomas Bird about a Neurology Today story on the topic of should there be a moratorium on human germline editing. DISCLOSURES: Dr. Abbott serves as an editorial board member of Keio Journal of Medicine Journal of Epidemiology, and receives non-profit research support from Pacific Health Research and Education Institute.Dr. Gross is supported for educational endeavors from the University of Rochester Medical Center's Clinical and Translational Science Award from the NIH; since his appointment as Editor-in-Chief in 2009, he has ceased participation in industry-sponsored clinical trials and speakers' bureaus and receives an honorarium from AAN as Editor-in-Chief of Neurology.Dr. Dorsey serves on the scientific advisory board of Shire Pharmaceuticals, Huntington's Disease Society of America and NINDS; serves as Editor for HD Insights; serves as an editorial board member of the Journal of Huntington's Disease; serves as Section Editor and Curator for Innovations in Care Delivery mini-site Neurology; received travel funding and honoraria from the American Academy of Neurology; has a patent application related to telemedicine; includes telemedicine in his clinical practice as a movement disorder neurologist (20% effort); has received compensation for expert testimony; is a consultant for 23andME, Amgen, Avid radiopharmaceuticals, Clintrex, Lundbeck Inc, MC10, Inc., Shire Pharmaceuticals, MedAvante, Transpanency Life Sciences and NINDS; receives research support from AMC Health, Avid Radiopharmaceuticals, Biogen Idec, Great Lakes Neurotechnologies, Lundbeck Inc, Medtronic, Inc., Prana Biotechnology, Agency for Health Care Research and Quality; NINDS, National Science Foundation, Patient-Centered Outcomes Research Institute; Davis Phinney Foundation, Michael J. Fox Foundation, Sage Bionetworks.Dr. Ted Burns serves as Podcast Editor for Neurology; and has received research support for consulting activities with UCB, CSL Behring, Walgreens and Alexion Pharmaceuticals, Inc.Dr. Bird serves as an editorial board member of GeneReviews.org; has a patent for Genetic testing technology for CMT1C and SCA14 and receives research support from the Department of Veterans' Affairs, Merit Research Grant.

1) Orthostatic tremor: Clinical, electrophysiologic and treatment findings in 184 patients2) What's Trending: Interview with Dr. Gretchen Birbeck about Global Neurology site, which will be called Without Borders3) Topic of the month: Neurology Today story about the SPRINT trial and lowering of blood pressure and strokeThis podcast for the Neurology Journal begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the print issue of Neurology. In the second segment Dr. Jeff Ratliff interviews Dr. Anhar Hassan about her paper on the clinical, electrophysiologic and treatment findings in 184 patients with orthostatic tremor. Dr. Robert Gross is interviewing Dr. Gretchen Birbeck for our "What's Trending" feature of the week about being the section editor and curator of our Global Neurology site, which will be called Without Borders. Dr. Ted Burns interviews Dr. James Grotta about a Neurology Today story on the topic of the SPRINT trial and lowering of blood pressure and stroke. DISCLOSURES: Dr. Gross is supported for educational endeavors from the University of Rochester Medical Center's Clinical and Translational Science Award from the NIH; since his appointment as Editor-in-Chief in 2009, he has ceased participation in industry-sponsored clinical trials and speakers' bureaus and receives an honorarium from AAN as Editor-in-Chief of Neurology.Dr. Birbeck serves as Section Editor and Curator for Without Borders mini-site Neurology; receives research support from the NIH and Dana Foundation Neuroimaging Grant.Dr. Ted Burns serves as Podcast Editor for Neurology; and has received research support for consulting activities with UCB, CSL Behring, Walgreens and Alexion Pharmaceuticals, Inc.Dr. Grotta serves as an editorial board member for International Journal of Stroke, serves as Consulting editor for Stroke; serves on the steering committee for a clinical trial, Lundbeck Inc.; is a consultant for Specialists on Call, Frazer ambulance and Haemonetics Corporation; has a patent for a composition and method for treatment of cerebral ischemia; receives royalties from the publication of the books Acute Stroke Care and Stroke: Pathology, Diagnosis, and Management; receives research support from Genentech, Inc., Haemonetics Corporation, Coviden, Halle Family/Discount Tire Fund, Alexander Foundation and Mobile Stroke Unit Fund (various donors).

1) Overdiagnosis of idiopathic intracranial hypertension2) e-Pearl topic: Neurologic manifestations of Hemolytic Uremic syndrome3) Topic of the month: Endovascular Stroke Therapy This podcast for the Neurology Journal begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the print issue of Neurology. In the second segment Dr. Jennifer Bickel interviews Dr. Valerie Biousse about her paper on overdiagnosis of idiopathic intracranial hypertension. Dr. Adam Numis is reading our e-Pearl of the week about neurologic manifestations of Hemolytic Uremic syndrome. In the next part of the podcast Dr. Prachi Mehndiratta interviews Dr. James F. Meschia about the topic of what's on the horizon in endovascular stroke therapy. DISCLOSURES: Dr. Biousse serves as an editorial board member of American Journal of Ophthalmology and Journal of Neuro-ophthalmology; is a consultant for GenSight; receives royalties from the publication of the books Walsh and Hoyt's Clinical Neuro-Ophthalmology, Neuro-Ophthalmology Illustrated and from Up-to-Date; and receives research support for Research to Prevent Blindness.Dr. Numis serves on the editorial team for the Neurology Resident and Fellow Section.Dr. Meschia serves as an editorial board member of Mayo Clinic Proceedings, Stroke and the European Journal of Neurology; receives research support from the NINDS for efforts devoted to the SiGN study.

1) Predictors for atrial fibrillation detection after cryptogenic stroke: Results from CRYSTAL AF2) e-Pearl topic: Treatment of pediatric onset neuromyelitis optica3) Topic of the month: Endovascular Stroke Therapy This podcast for the Neurology Journal begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the print issue of Neurology. In the second segment Dr. Bryan Eckerle interviews Dr. Vincent Thijs about his paper on predictors for atrial fibrillation detection after cryptogenic stroke. Dr. Adam Numis is reading our e-Pearl of the week about treatment of pediatric onset neuromyelitis optica. In the next part of the podcast Dr. Prachi Mehndiratta interviews Dr. Lee H. Schwamm about the topic of implications for stroke systems of care in endovascular stroke therapy. DISCLOSURES: Dr. Thijs serves as an Associate Editor for Acta Neurologica Belgica; serves as an editorial board member of Stroke and European Journal of Emergency Medicine; serves on the scientific advisory board for Sygnis Ax200 steering committee, Boehringer Ingelheim Belgium advisory board, Boehringer Ingelheim international advisory board, Medtronic steering committee of the REACT-AF trial; is a consultant for Boehringer Ingelheim, Pfizer Inc, Bayer Schering Pharma, AstraZeneca. Medtronic, Inc.; serves on the speakers bureau of Pfizer Inc, Boehringer Ingelheim and Medtronic, Inc.; received funding for travel or speaker honoraria from Medtronic, Inc.; Boehringer Ingelheim, Pfizer Inc, and Bayer Schering Pharma; receives research support from SYGNIS AG, Medtronic, Inc., Pfizer Inc, AstraZeneca, Boehringer Ingelheim and VIB Flanders Research Fund (FWO).Dr. Numis serves on the editorial team for the Neurology Resident and Fellow Section.Dr. Schwamm serves on the scientific advisory board for CoAxia, Lundbeck Inc. DIAS 4 steering Committee, LifeImage and Medtronic, Inc.; serves as an editorial board member for Neurocritical Care, Stroke and Frontiers in TeleNeurology; receives royalties from the publication of the book Acute Ischemic Stroke: Imaging and Intervention, 2nd Edition; is a consultant for Lundbeck Inc. DIAS 4 steering Committee, LifeImage, Medtronic, Inc., and Massachusetts Department of Public Health; has a patent for Imaging system for obtaining quantitative perfusion indices. US Patent 6,542,769. 2003 Apr 1, The General Hospital Corporation assignee, Inventors: Schwamm LH and Sorensen AG; is the principal investigator of an investigator-initiated study of extended-window intravenous thrombolysis funded by the National Institutes of Neurological Disorders and Stroke (clinicaltrials.gov/show/NCT01282242) for which Genentech provides alteplase free of charge to Massachusetts General Hospital as well as supplemental per-patient payments to participating sites; is the chair of the AHA/ASA GWTG stroke clinical work group.

1) Neurology® Clinical Practice: Anti-GAD syndrome with concomitant cerebellar ataxia, stiff-person syndrome, and limbic encephalitis2) What's Trending: Current exciting projects at the AAN3) Topic of the month: Endovascular Stroke Therapy This podcast for the Neurology Journal begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the print issue of Neurology. In the second segment Dr. Alex Menze interviews Dr. Sara Schaefer about her Neurology: Clinical Practice paper on anti-GAD syndrome with concomitant cerebellar ataxia, stiff-person syndrome, and limbic encephalitis. Dr. Ted Burns is interviewing Cathy Rydell for our "What's Trending" feature of the week about current exciting projects happening at the AAN. In the next part of the podcast Dr. Prachi Mehndiratta interviews Dr. Max Wintermark about the topic of imaging modalities used as selection criteria in endovascular stroke therapy. DISCLOSURES: Dr. Ted Burns serves as Podcast Editor for Neurology®; and has received research support for consulting activities with UCB, CSL Behring, Walgreens and Alexion Pharmaceuticals, Inc.Catherine M. Rydell is Executive Director & Chief Executive Officer, American Academy of Neurology.Dr. Wintermark serves as an editorial board member of American Journal of Neuroradiology and American Journal of Roentgenology; serves on the scientific advisory board for the GE-NFL board.NO CME WILL BE OFFERED THIS WEEK.

Physician Burnout; a primer for neurologists

1) Pregnancy outcomes in aquaporin-4 positive neuromyelitis optica2) What's Trending: Safety and tolerability of resveratrol for Alzheimer disease3) Topic of the month: Endovascular Stroke Therapy This podcast for the Neurology Journal begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the print issue of Neurology. In the second segment Dr. Melanie Ward interviews Dr. Maria Isabel S. Leite about her paper on pregnancy outcomes in aquaporin-4 positive neuromyelitis optica. Dr. Ted Burns is interviewing Dr. R. Scott Turner for our "What's Trending" feature of the week about his paper on a randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease. In the next part of the podcast Dr. Prachi Mehndiratta interviews Dr. Pooja Khatri about the topic of broad overview of the new clinical trials in endovascular stroke therapy. DISCLOSURES: Dr. Leite serves as an editorial board member for Neuromuscular Disorders; has received travel grant and speaking honoraria from Biogen Idec and travel grant from Novartis; is supported by NHS National Specialized Commissioning Group for Neuromyelitis Optica, UK and by NIHR Oxford Biomedical Research Centre.Dr. Ted Burns serves as Podcast Editor for Neurology®; and has received research support for consulting activities with UCB, CSL Behring, Walgreens and Alexion Pharmaceuticals, Inc.Dr. Turner serves on the data safety and monitoring board for the National Institute on Aging; serves as an editorial board Member for Frontiers in Neuroscience and Neuropsychology and Cognition; receives research support from the National Institute on Aging.Dr. Khatri provided expert witnessing for stroke cases over last two years; receives research support from Penumbra, Inc, Genentech, Inc. and the NIH.

1) Neurology® Neuroimmunology & Neuroinflammation Journal: Basal ganglia T1-hyperintensity in LGI1-autoantibody faciobrachial dystonic seizures and 2) Topic of the month: Neurology Today: Recent Publications. This podcast for the Neurology Journal begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the print issue of Neurology. In the second segment Dr. Jeff Waugh interviews Dr. Eoin Flanagan about his Neurology: Neuroimmunology & Neuroinflammation paper on basal ganglia T1-hyperintensity in LGI1-autoantibody faciobrachial dystonic seizures. Dr. Adam Numis is reading our e-Pearl of the week about genetic testing in facioscapulohumeral dystrophy. In the next part of the podcast Dr. Ted Burns interviews Dr. Steve Ringel about a Neurology Today story on the topic of immunotherapy for autoimmune cerebellar ataxia. The participants had nothing to disclose except Drs. Numis, Burns and Ringel.Dr. Numis serves on the editorial team for the Neurology® Resident and Fellow Section. Dr. Ted Burns serves as Podcast Editor for Neurology®; and has received research support for consulting activities with UCB, CSL Behring, Walgreens and Alexion Pharmaceuticals, Inc.Dr. Ringel serves as editor of Neurology Today.NO CME WILL BE OFFERED THIS WEEK.

1) Response to shunting and predictors of response in idiopathic normal pressure hydrocephalus and 2) Topic of the month: Neurology Today: Recent Publications. This podcast for the Neurology Journal begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the print issue of Neurology. In the second segment Dr. Farrah Mateen interviews Dr. John Halperin about the AAN guideline on response to shunting and predictors of response in idiopathic normal pressure hydrocephalus. Dr. Ted Burns is interviewing Dr. Qadeer Arshad for our "What's Trending" feature of the week about his paper on electrocortical therapy for motion sickness. In the next part of the podcast Dr. Ted Burns interviews Dr. Lorenz Studer about a Neurology Today story on the topic of stem cell therapy in Parkinson disease.The participants had nothing to disclose except Drs. Mateen, Halperin, Burns and Studer. Dr. Mateen received research support from the Canadian Institute of Health Research.Dr. Halperin serves as an editorial board member of The Neurologist, ACP PIER, Current Neurology & Neuroscience Reports; serves on the evidence-based medicine group for Neurology®; receives speakers' honoraria from the American Academy of Neurology, Flemish Neurological Society, University of Maryland, Winthrop University Hospital and Inova Health System; receives royalties from the publication of the book Lyme disease-An evidence-based approach and from Up-to-Date; gave expert testimony in medical malpractice cases defending physicians related to Lyme disease; received research support from Centers for Disease Control & Prevention, Lyme disease vs. MS.Dr. Ted Burns serves as Podcast Editor for Neurology®; and has received research support for consulting activities with UCB, CSL Behring, Walgreens and Alexion Pharmaceuticals, Inc.Dr. Studer serves on the scientific advisory board for Allen Brain Institute and Neurona Irc.; received travel of compensation Allen Brain Institute and Neurona Irc.; is a consultant for Allen BrainInstitute and Neurona Irc.; is a consultant for Allen Brain Institute and Neurona Irc.; has a patent for dopaminergic neuron.

1) Endovascular versus medical management of acute ischemic stroke and 2) Topic of the month: Neurology Today: Recent Publications. This podcast for the Neurology Journal begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the print issue of Neurology. In the second segment Dr. Kevin Barrett interviews Dr. Brad Worrall about his paper on endovascular versus medical management of acute ischemic stroke. Dr. Ted Burns is interviewing Dr. Daniel Kaufer for our "What's Trending" feature of the week about the AAN Behavioral Neurology Section Workgroup paper on improving clinical cognitive testing. In the next part of the podcast Dr. Ted Burns interviews Dr. Steve Ringel about a Neurology Today story on the topic of defective nuclear transport and endogenous retrovirus in ALS. The participants had nothing to disclose except Drs. Barrett, Worrall, Burns, Kaufer and Ringel.Dr. Kevin Barrett serves as an Associate Editor of Neurohospitalist; serves as an editorial board member of Neurology; and receives research support from the NIH.Dr. Worrall serves as Associate Editor for Neurology®; receives royalties as Chapter Author for Merritt's Neurology editions 10, 11, and 12; and receives research support from the NIH.Dr. Ted Burns serves as Podcast Editor for Neurology®; and has received research support for consulting activities with UCB, CSL Behring, Walgreens and Alexion Pharmaceuticals, Inc.Dr. Kaufer is a consultant for Janssen Research and Development; receives research support from TauRx Therapeutics Ltd, Navidea Biopharmaceuticals, Inc., Guardian Angel Thrift Fund, National Football League Players Association and the NIH.Dr. Ringel serves as editor of Neurology Today.