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By Dr. Michael Hyland, DPT, CEEAA
4.4
3232 ratings
The podcast currently has 146 episodes available.
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Most Parkinson's treatments focus on replacing dopamine—but what if a medication could target some of the underlying disease processes instead? In this episode, we take a closer look at Fasudil, an experimental therapy that is generating interest in the Parkinson's research community. Originally developed for a completely different neurological condition, Fasudil is now being studied for its potential effects on neuroinflammation, alpha-synuclein accumulation, cellular repair mechanisms, and other pathways involved in Parkinson's disease. We'll discuss: What Fasudil is and how it works The role of ROCK inhibition in Parkinson's research Potential effects on inflammation and alpha-synuclein What animal studies have shown so far The current status of human clinical trials What people with Parkinson's should know right now While Fasudil is not currently an approved treatment for Parkinson's disease, it represents an exciting example of how researchers are looking beyond dopamine to develop future therapies that may one day slow disease progression. Help to support this channel and our efforts to educate the world about Parkinson's Disease and get access to personalized content: https://www.youtube.com/channel/UC0g3abv8hkaqZbGD8y1dfYQ/join https://www.patreon.com/pdeducation Please be sure to give support to our channel sponsors: Comfort Linen: https://comfortlinen.com/PARKINSONSDISEASEEDUCATION (15% off entire order when applying the code PARKINSONSDISEASEEDUCATION at checkout) Kizik Shoes: https://kizik.sjv.io/pdeducation Cure Hydration: https://lvnta.com/lv_XG06Rho8SSlXEq3qlV If you have products that you would like for me to review on the channel please send them here: Parkinson's Disease Education P.O. Box 1678 Broken Arrow, OK 74013 Medical Disclaimer All information, content, and material of this video is for informational purposes only and not intended to serve as a substitute for the consultation, diagnosis, and/or medical treatment of a qualified physician or healthcare provider. Affiliate disclaimer: Keep in mind that links used for recommended products may earn me a commission when you make purchases. However, this does not impact what products I recommend. If I recommend a specific product it is because it has been vetted by myself or based on personal use

Welcome to the 20,000 Subscriber Special! The sponsor of today's episode is Contour Design and the tremor-friendly RollerMouse Red. Be sure to use the code PDEDUCATION at checkout to receive a discount: https://lvnta.com/lv_ipnUBU2K33mzi8eRd4 In this episode (watch on YouTube), I share 20 of the most important things I've learned from working with people living with Parkinson's Disease as a physical therapist. Some are clinical observations. Some are misconceptions that need to be challenged. Others are lessons about resilience, humanity, and the incredible strength of the Parkinson's community. We talk about: • Why Parkinson's is far more than a movement disorder • The hidden world of non-motor symptoms • Tremors, freezing, festination, dystonia, and dyskinesia • Why stress and emotion can worsen physical symptoms • The complicated relationship between medication and symptom management • The neuroprotective role of exercise and physical therapy • Why Parkinson's remains misunderstood — even within healthcare • And why the people living with Parkinson's continue to inspire me every single day This episode is not meant to replace medical advice, diagnosis, or treatment. It is a conversation shaped by years of clinical experience, evidence-based rehabilitation, and most importantly, the people who trusted me to be part of their journey. Whether you are living with Parkinson's, caring for someone who is, or simply trying to understand the disease better, I hope this episode helps you feel more informed, more seen, and more hopeful. For members-first content, early access, and to help to support this channel sign up for memberships here: https://www.youtube.com/channel/UC0g3abv8hkaqZbGD8y1dfYQ/join https://www.patreon.com/pdeducation Please be sure to give support to our channel sponsors: Comfort Linen: https://comfortlinen.com/PARKINSONSDISEASEEDUCATION(15% off entire order when applying the code PARKINSONSDISEASEEDUCATION at checkout) Kizik Shoes: https://kizik.sjv.io/pdeducation Cure Hydration: https://lvnta.com/lv_XG06Rho8SSlXEq3qlV If you have products that you would like for me to review on the channel please send them here: Parkinson's Disease Education P.O. Box 1678 Broken Arrow, OK 74013 Medical Disclaimer: All information, content, and material of this video is for informational purposes only and not intended to serve as a substitute for the consultation, diagnosis, and/or medical treatment of a qualified physician or healthcare provider. Affiliate disclaimer: Keep in mind that links used for recommended products may earn me a commission when you make purchases. However, this does not impact what products I recommend. If I recommend a specific product it is because it has been vetted by myself or based on personal use #parkinsonsawareness #parkinsonsdisease #parkinsons #physicaltherapy #neurology #lsvtbig #neurorehabilitation

Knowing what to do is only part of the challenge in Parkinson's disease. The harder part? Staying consistent. In this final episode (watch on YouTube) of our Parkinson's Communication Roadmap series, we focus on practical ways to make speech, voice, and communication exercises part of everyday life—without feeling overwhelmed. We cover: • How to stay consistent with voice and speech practice • Building therapy into daily routines • Habit stacking and "mini therapeutic moments" (See Atomic Habits by James Clear 👉 https://amzn.to/4dZhJDV) • Functional carryover strategies that work in real life • Using music and singing as therapy • Parkinson's choirs and music-based activities • Motivation, accountability, and sustainable routines We also discuss how programs like Get LOUD! Stay LOUD! help people stay engaged through guided practice, community support, and short, manageable daily exercises. This episode is all about shifting from: 👉 "I should do my exercises" to 👉 "This is simply part of how I live." Because long-term success in Parkinson's communication doesn't come from perfection—it comes from consistency. 👥 Featuring collaboration with Sarah Awde, M.Cl.Sc. Speech Language Pathology (Get LOUD! Stay LOUD!) Sign up for Get LOUD Stay LOUD using the link. Try FREE for 30 days, and use code HYLAND50 to get 50% off your first paid month 👉 http://getloudstayloud.mn.co/users/onboarding/plans?via=michael Not sure which classes are the best fit for you? Take the class finder survey here: https://form.jotform.com/253162339857364 📌 Subscribe for more Parkinson's education, therapy strategies, and practical tools for everyday life. For members-first content, early access, and to help to support this channel sign up for memberships here: https://www.youtube.com/channel/UC0g3abv8hkaqZbGD8y1dfYQ/join https://www.patreon.com/pdeducation Please be sure to give support to our channel sponsors: Comfort Linen: https://comfortlinen.com/PARKINSONSDISEASEEDUCATION (15% off entire order when applying the code PARKINSONSDISEASEEDUCATION at checkout) Kizik Shoes: https://kizik.sjv.io/pdeducation Cure Hydration: https://lvnta.com/lv_XG06Rho8SSlXEq3qlV If you have products that you would like for me to review on the channel please send them here: Parkinson's Disease Education P.O. Box 1678 Broken Arrow, OK 74013 Medical Disclaimer: All information, content, and material of this video is for informational purposes only and not intended to serve as a substitute for the consultation, diagnosis, and/or medical treatment of a qualified physician or healthcare provider. Affiliate disclaimer: Keep in mind that links used for recommended products may earn me a commission when you make purchases. However, this does not impact what products I recommend. If I recommend a specific product it is because it has been vetted by myself or based on personal use #parkinson #parkinsonsawareness #parkinsonsdisease #parkinsons #voicetherapy #habitstacking #speechtherapy

Fibroblast Growth Factor-1 (FGF-1) is being discussed as a potential regenerative therapy for Parkinson's disease. Some claim it may protect or even restore dopamine-producing neurons. But what does the science actually say? In this episode, we break down: • What FGF-1 is and how it works • Why growth factors are being explored in Parkinson's disease • How FGF-1 compares to decades of research on Glial cell line-derived neurotrophic factor (GDNF) • What animal studies show — and what human trials do not yet show • The risks, unknowns, and delivery challenges • How to think critically about regenerative claims Parkinson's disease urgently needs disease-modifying therapies. Growth factors are biologically plausible and scientifically interesting — but promising is not the same as proven. This video is an evidence-based look at where FGF-1 stands today. If you're living with Parkinson's, caring for someone who is, or simply trying to understand the science behind emerging therapies, this episode is for you. This episode is for educational purposes only and does not constitute medical advice. Head here to learn more about the FGF-1 work being done at Zhittya Genesis Medicine: https://www.pd-studies.org/ Help to support this channel and our efforts to educate the world about Parkinson's Disease and get access to personalized content: https://www.youtube.com/channel/UC0g3abv8hkaqZbGD8y1dfYQ/join https://www.patreon.com/pdeducation Please be sure to give support to our channel sponsors: Comfort Linen: https://comfortlinen.com/PARKINSONSDISEASEEDUCATION(15% off entire order when applying the code PARKINSONSDISEASEEDUCATION at checkout) Kizik Shoes: https://kizik.sjv.io/pdeducation Cure Hydration: https://lvnta.com/lv_XG06Rho8SSlXEq3qlV If you have products that you would like for me to review on the channel please send them here: Parkinson's Disease Education P.O. Box 1678 Broken Arrow, OK 74013 Medical Disclaimer: All information, content, and material of this video is for informational purposes only and not intended to serve as a substitute for the consultation, diagnosis, and/or medical treatment of a qualified physician or healthcare provider. Affiliate disclaimer: Keep in mind that links used for recommended products may earn me a commission when you make purchases. However, this does not impact what products I recommend. If I recommend a specific product it is because it has been vetted by myself or based on personal use #parkinsonsawareness #FGF1#Neuroprotection #ParkinsonsResearch #DiseaseModifyingTherapy #MovementDisorders

MRI-guided Focused Ultrasound (FUS) is an FDA-approved treatment option for certain motor symptoms of Parkinson's Disease — particularly medication-refractory tremor and levodopa-induced dyskinesia. But what exactly does it do? And just as importantly — what does it not do? In this episode, I break down: • How MRI-guided Focused Ultrasound works • What part of the brain is targeted • Who may be an appropriate candidate • How it compares to Deep Brain Stimulation (DBS) • The risks, limitations, and realistic expectations Focused ultrasound is not a cure for Parkinson's. It does not slow disease progression. But for carefully selected patients, it can meaningfully reduce specific motor symptoms. As always, this episode is for educational purposes only and is not individual medical advice. Treatment decisions should be made with your neurologist and care team. If you find this helpful, consider subscribing for more evidence-based discussions on Parkinson's treatment options. Help to support this channel and out efforts to educate the world about Parkinson's Disease and get access to personalized content: https://www.youtube.com/channel/UC0g3abv8hkaqZbGD8y1dfYQ/join https://www.patreon.com/pdeducation Please be sure to give support to our channel sponsors: Comfort Linen: https://comfortlinen.com/PARKINSONSDISEASEEDUCATION (15% off entire order when applying the code PARKINSONSDISEASEEDUCATION at checkout) Kizik Shoes: https://kizik.sjv.io/pdeducation Cure Hydration: https://lvnta.com/lv_XG06Rho8SSlXEq3qlV If you have products that you would like for me to review on the channel please send them here: Parkinson's Disease Education P.O. Box 1678 Broken Arrow, OK 74013 Medical Disclaimer All information, content, and material of this video is for informational purposes only and not intended to serve as a substitute for the consultation, diagnosis, and/or medical treatment of a qualified physician or healthcare provider. Affiliate disclaimer: Keep in mind that links used for recommended products may earn me a commission when you make purchases. However, this does not impact what products I recommend. If I recommend a specific product it is because it has been vetted by myself or based on personal use. #parkinson #parkinsonsawareness #parkinsonsdisease #parkinsons #focusedultrasound #fus
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