The oldest of four boys, Pascal Soriot grew up in a working class area of Paris. He took the helm at AZ in 2012 after years in top jobs across the world. One of his first challenges was to fight off a takeover from Pfizer. The AZ vaccine, currently not-for-profit, was hailed as a life saver for millions. But with accusations of confusing drug trial data, dishonest dealings with the EU and safety fears, has the AstraZeneca CEO lost his shine?

Presenter: Mark Coles

Researcher: Matt Murphy

Studio manager: Graham Puddifoot

Programme co-ordinator: Janet Staples

Producer: Linda Pressly

Editor: Rosamund Jones