Before NFTs were a category and crypto was an industry, two artists released 10,000 characters into the world with no roadmap, no pitch, and no expectations. What started as an art experiment in code ended up flourishing into a movement about ownership and identity. In this episode of Possible, Reid sits down with Matt Hall and John Watkinson, co-founders of Larva Labs and creators of CryptoPunks, to trace how a small creative experiment became one of the most influential cultural phenomenons of the internet era. They reflect on what it means for art to live on-chain, why decentralization was a design choice rather than a slogan, and how digital identity became one of the most valuable real estates online. From museums and blockchains to profile pictures, permanence, the conversation explores how letting go of narrative control can allow culture and community to write the story themselves.

This episode is our third and final installment of a special, three-part Reid Riffs miniseries focused on what it actually means to become AI-native. In this episode, Parth shares how founders can rethink work by breaking problems into modular pieces, orchestrating AI agents in parallel, and collapsing timelines that once required entire teams days of iteration. Using real-world examples like coding agents that tackle week-long engineering challenges to reimagining how content can be localized across languages and regional markets, the conversation explores how AI enables small teams to operate with outsized leverage. Along the way, Reid and Parth discuss what separates real AI traction from “AI theater,” how founding teams are evolving, and why the most powerful AI often works best when it fades into the background, quietly amplifying human creativity and ambition.

For more info on the podcast and transcripts of all the episodes, visit https://www.possible.fm/podcast/

This episode is our second installment of a special, three-part Reid Riffs miniseries focused on what it actually means to become AI-native. Instead of a news or headline-driven conversation, Reid sits down one-on-one with AI engineer and strategist, Parth Patil, for a deeper exploration of how AI is changing the way people and organizations work. In this second episode, they discuss why most enterprises are still talking about AI without truly integrating it (“AI theater”), and how the real shift begins inside everyday workflows rather than strategy decks. Together, they explore how language models and agents can reduce friction in communication and coordination, reinvent meetings, and turn unstructured information into actionable insight (with examples). They also examine how AI-powered analysis, automation, and parallelized agents are accelerating decision-making, reshaping roles, and moving work from execution toward orchestration. Parth and Reid both highlight how an open mindset and experimentation are required to collaborate effectively with these systems as AI evolves from a productivity tool into a foundational layer for thinking and leadership.

Subscribe below to catch the third episode for startup founders and their early teams building AI-native companies. 

For more info on the podcast and transcripts of all the episodes, visit https://www.possible.fm/podcast/ 

This is the first of a special, three-part Reid Riffs miniseries. Instead of a news-and-headline driven conversation, Reid sits down one-on-one with Parth Patil, an AI engineer and strategist, for a deeper exploration of what it actually means to become AI-native. In this first episode of the series, Parth and Reid discuss how individuals can better leverage LLMs, agents, and creative tools daily. They trace the shift from seeing AI as a productivity boost to understanding it as a meta-tool, as well as unpack techniques like role-based prompting, meta-prompting, and voice as a high-bandwidth thinking interface. Along the way, they discuss the humility required to collaborate with these systems, the move from a single copilot to orchestrating fleets of specialized agents, and how these tools are already reshaping workflows.

Subscribe below to catch the second episode on how large companies can integrate AI, as well as the third episode for startup founders and their early teams building AI-native companies. 

For more info on the podcast and transcripts of all the episodes, visit https://www.possible.fm/podcast/ 

01:07 – When ChatGPT became an “everything tool”

On this episode of Possible, Reid Hoffman and Aria Finger sit down with Amjad Masad, founder and CEO of Replit, to explore how AI is fundamentally changing who gets to build software and what that means for work, creativity, and human agency. Masad traces his journey from growing up in Jordan teaching himself to code and connects it to his love of video games which helped inspire him to build a platform that turns natural language into working software. The conversation spans everything from why gaming mindsets make better builders, to how CEOs are rediscovering hands-on creation, to why “vibe coding” is the next form of literacy and why computational thinking is more important than syntax mastery. The conversation also digs into the future of AI agents, long-running autonomous workflows, and what it means to design environments for machines rather than humans. They also confront harder questions about jobs, fear, regulation, and society’s responsibility during a cognitive industrial revolution. The episode ultimately reframes AI not as a replacement for human creativity, but as a force that can return people to a more entrepreneurial, expressive, and meaningful way of life. 

For more info on the podcast and transcripts of all the episodes, visit https://www.possible.fm/podcast/

01:45 – Introductions and Amjad’s background

02:07 – Growing up in Jordan, video games, and learning to build

06:19 – How gaming culture shaped Replit’s product philosophy

09:55 – Designing Replit around safety, reversibility, and exploration

13:24 – Defining vibe coding and where the term came from

15:55 – The new literacy: computational thinking and soft skills

22:09 – Getting past the blank page and learning by making

25:06 – Entrepreneurs, solopreneurs, and who Replit empowers

30:48 – Designing environments for AI agents and durable businesses

35:55 – Open source, abstraction, and “cathedrals built from bazaars”

38:25 – The future of corporate work and creative ownership

48:29 – Fear, skepticism, and cultural responsibility around AI

54:13 – Jobs, disruption, and becoming AI-native in a changing economy

01:11:12 – Rapid Fire Questions

This is a bonus episode from the Conversations of Coleman podcast, featuring Reid Hoffman as the guest. Here are the show notes from that episode:

My guest today is entrepreneur and LinkedIn co-founder Reid Hoffman. He’s now facing something most tech business people never imagine: being personally targeted by a sitting president’s Department of Justice. Reid and I talk through the rise of politically motivated prosecutions, the erosion of trust in institutions, and how social media and AI have accelerated our collective slide into suspicion. We get into deepfakes, vaccine skepticism, the inequality debate, and whether billionaires should exist at all. Reid also walks me through what it’s like to wait for an indictment he believes is purely retaliatory. This is a conversation about democratic guardrails, not partisan talking points—and about what happens when political power becomes personal.

A big thanks to The Free Press and Conversations with Coleman podcast, available at theFP.com. 

This is a holiday special re-airing of our excellent episode with Stephen Colbert.

What could we gain—and what might we lose—when technology begins to approximate the contours of human connection and presence? In this episode, Reid and Aria chat with comedian, actor, and political commentator Stephen Colbert. Best known for hosting The Colbert Report and The Late Show, Stephen combines a razor sharp satire with a sincere curiosity about the world. Together, Reid, Aria, and Stephen discuss the art of live performance, the many lessons one can learn from J.R.R. Tolkien, and the nature of creativity, humor, and imagination in the age of AI. The result is a meditation on discovery, empathy, and the bonds that make connection more than performance — but a shared act of being human.

In this special episode of Reid Riffs, Reid and Aria are joined by Pulitzer Prize–winning author, oncologist, and Manas AI cofounder Siddhartha Mukherjee for a few questions about cancer, AI, and the second edition of The Emperor of All Maladies. Reflecting back on the 15 years since its initial publication, Reid, Aria and Sid discuss how cancer prevention, early detection, and immunotherapy have fundamentally shifted while the disease continues to be a defining challenge of modern medicine. The conversation charts how AI can become a true engine of drug discovery and how Manas was built to be an AI-native biopharmaceutical company focused on developing entirely new medicines. The episode then broadens out to tackle the current cultural moment in Silicon Valley, questioning whether the Valley is entering a new Renaissance driven by more meaningful work, clearer values, and a renewed theory of human progress. The episode closes by grappling with AI’s growing persuasive power in politics and public discourse, and the responsibility to design systems that elevate truth, agency, and humanity rather than distort them.

In this episode of Reid Riffs, Reid and Aria explain why "compute" is the new oil powering the cognitive industrial revolution. They argue that the United States must urgently expand domestic data centers and energy infrastructure to remain globally competitive. The conversation explores how rapid data center construction is transforming blue-collar labor markets, driving significant wage growth for electricians, HVAC technicians, and skilled trades while dispelling misinformation about data centers' impact on rising electricity costs. Reid warns that China's aggressive energy expansion is also widening the global competitiveness gap, underscoring the need for stable, long-term U.S. energy policy spanning nuclear, natural gas, solar, and wind. Reid and Aria also discuss how America's next era of prosperity hinges on how decisively it builds the physical backbone of AI and why keeping AI infrastructure on U.S. soil is critical for jobs, intellectual property, and national security.

In this special live episode of Possible, Reid and Aria sit down with Wispr Flow founder and CEO Tanay Kothari to explore a post-keyboard future where voice becomes the primary way humans interact with computers. From building one of the world’s first voice assistants as a child to creating a product now used the world over (with, as of publish, 70% user retention after one year and daily users at over half of the Fortune 500), Tanay shares how Wispr Flow removes the cognitive friction of typing and restores natural communication to our digital world. The conversation touches on increasing accessibility to AI, emotional tone in digital communication, and why speaking to computers may ultimately be more human than typing ever was. And shortly into the conversation, Tanay puts his tech to the test in a live demo that pits a 110-words-per-minute typist against Wispr Flow in a dramatic battle of speed and accuracy. This episode showcases what is possible in a future where technology fades into the background and nudges people to become more present in the real world.

A big thanks to Sean Mendy and the Westbound Equity Partners, and David Stiepleman and the Sixth Street Partners for hosting the conversation. And a shout to Isabella Sikaffy and the Florabella Studios team, Marshall Potter and the Push Record team, and Marcus Chua and the Wispr Flow team.