This week the political turmoil at Number 10 has made the headlines. One of the prime minister's aides whose star appears to be on the rise is former journalist Allegra Stratton, the government's new press secretary. She'll be fronting televised briefings shortly. Becky Milligan examines her life and her career so far.

Early results from the world's first effective coronavirus vaccine showed it could prevent more than 90% of people from getting Covid-19.

The vaccine had been developed by pharmaceutical companies Pfizer and BioNTech and was one of 11 vaccines that had reached the final stages of testing.

Mark Coles explores the lives and careers of Ugur Sahin and Ozlem Tureci - the little known Turkish-German husband-and-wife team responsible for the development of the vaccine.

First broadcast on Saturday 14th November 2020.

Producers: Sally Abrahams and Ben Carter

As Wales eases its covid restrictions, Profile explores the life and various careers of the country's First Minister. Born and brought up in rural Wales, before entering the world of Labour politics Mark Drakeford worked as a social worker and an academic. And Mark Coles discovers that those are not his only interests. Tending his allotment, playing music and body boarding in all weathers also loom large.

The business woman and Great British Bake Off judge now working with the government to improve NHS food - her independent review demanding healthier meals for hospital patients.

Born in South Africa, it was time spent in Paris which sparked Prue Leith's love of food. Transferring to London, she started a food empire in her bedsit, going on to open a catering college and a Michelin star restaurant.

She took on public roles too, becoming the first woman on the board of British Rail, charged with fixing the network's food which had become a laughing stock.

Prue built her media profile alongside roles in the arts, charity sector and education. Then after controversial team-changes in The Great British Bake Off, she's now become a bona fide celebrity, helping the hit programme reach record audiences.

Producers: Richard Fenton-Smith & Ben Crighton

The chief strategic advisor to PM Boris Johnson who thrives on getting things done and who was once regarded as Margaret Thatcher's favourite council leader.

A former alarms company executive, Edward Lister's political career began in the London Borough of Wandsworth which was at the forefront of Thatcherism at the turn of the 1980s.

A council leader for nearly two decades, he made the leap to City Hall when Boris Johnson made him his deputy - and he's been a trusted aide and fixer ever since.

Despite his position, Sir Edward has kept a low public profile, working behind the scenes resolving recent Brexit stalemates.

This week he's been the go-between in the negotiations between the government and city mayors in the North of England in the debate over the financial cost of Covid-19.

Mark Coles profiles the life of the man described as the 'grown-up' at Number 10 who thrives on solving problems.

Producers: Richard Fenton-Smith & Ben Crighton

The former bricklayer steering Liverpool through the latest coronavirus lockdown. Liverpool was the first region to face the toughest restrictions as the second wave of the pandemic takes hold. The man in charge of dealing with this new crisis is the first mayor of the city region, Steve Rotheram. Becky Milligan charts his rise, from a 16-year-old school leaver to prominent politician.

The man from Indiana who's "a heartbeat away" from the US presidency. Mark Coles tells the story of how a Catholic boy with Democratic Party leanings became a born-again evangelical and a hero of the Republican right. With President Donald Trump's recent bout with Covid-19, there has been more and more attention paid to the man next in line for the Oval Office. But there are doubts about whether a majority of the American public agree with the vice-president's strictly socially conservative views.

Billionaire Chuck Feeney said he would give away all of his money by 2020 – and he’s done it. An entrepreneur from childhood, he amassed a huge fortune in the duty-free business, before spending it on projects ranging from concert halls in Ireland to AIDS support in South Africa. For many years the money was only given out on condition of secrecy, that his name should never be mentioned in connection with the donations.

Mark Coles finds out what’s driven this unique mission - and what his family think.

Producer: Ben Crighton

Lewis Hamilton could be about to equal Michael Schumacher's incredible record of 91 Grand Prix wins - but can he achieve even more? The first black Formula 1 driver has been a champion since childhood, when he ran rings around the adults with his remote control car. Three decades on he's tipped to equal and even exceed the long standing record - but is he now determined to achieve as much off the track as on it? We hear from those who know Hamilton best, including an exclusive interview with his father, Anthony.

Presenter: Becky Milligan

The woman who could soon be "a heartbeat away" from the presidency. This week voters in some states started sending in their ballot papers for the US presidential election. If the Democrats win when results are announced in November, it's vice presidential candidate Kamala Harris who'll be second in line to the Oval Office. She would be the first black person, the first woman and the first person of Indian descent to become VP. But what is Kamala Harris really like? Why has she attracted criticism in some circles for her record as a prosecutor and a legislator, while being hailed a hero by others? And is she likely to attract voters to Joe Biden's presidential campaign, or drive them away?

Presenter: Mark Coles