Real Life Pharmacology - Pharmacology Education for Health Care Professionals

By Eric Christianson, PharmD; Pharmacology Expert and Clinical PharmacistMedicine Health & Fitness Education

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Real Life Pharmacology - Pharmacology Education for Health Care Professionals episodes

October 17, 2019 Erythromycin Pharmacology
Erythromycin uniquely has some potential benefit in the setting of gastroparesis. Azithromycin you will likely not see used for this indication.

Erythromycin binds the 50s subunit and ultimately prevents protein synthesis which is necessary for bacteria to grow and replicate.

QTc prolongation is a risk with all macrolide antibiotics (erythromycin included).

By inhibiting CYP3A4, erythromycin can be responsible for numerous drug interactions.
13 min
October 10, 2019 Naloxone Pharmacology
Naloxone is a life saving drug that can help manage an opioid overdose situation.
Naloxone blocks opioids receptors so opioid agonists cannot bind there.
One of the biggest risks with opioid overdose includes respiratory depression. Naloxone can help reduce the risk of this if administered in a timely manner.
IV naloxone will have the quickest physiological onset of action, but nasal naloxone may be the best opportunity in the community to get this drug on board quickly.
Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

15 min
October 10, 2019 Naloxone Pharmacology
Naloxone is a life saving drug that can help manage an opioid overdose situation.

Naloxone blocks opioids receptors so opioid agonists cannot bind there.

One of the biggest risks with opioid overdose includes respiratory depression. Naloxone can help reduce the risk of this if administered in a timely manner.

IV naloxone will have the quickest physiological onset of action, but nasal naloxone may be the best opportunity in the community to get this drug on board quickly.
15 min
October 03, 2019 Prochlorperazine Pharmacology
Prochlorperazine has several potential mechanisms of action. It can block dopamine and alpha receptors as well as have anticholinergic effects.
Prochlorperazine is classified as an antipsychotic and antiemetic. It is very seldom used as an antipsychotic in clinical practice and more used for its antiemetic effects.
Because of the anticholinergic activity of prochlorperazine, there is potential for dry mouth, dry eyes, urinary retention, constipation, and other anticholinergic effects.
Prochlorperazine does have the potential to have some alpha blocking activity. Keep an eye out for hypotension in patients who may be at risk.
Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

13 min
October 03, 2019 Prochlorperazine Pharmacology
Prochlorperazine has several potential mechanisms of action. It can block dopamine and alpha receptors as well as have anticholinergic effects.

Prochlorperazine is classified as an antipsychotic and antiemetic. It is very seldom used as an antipsychotic in clinical practice and more used for its antiemetic effects.

Because of the anticholinergic activity of prochlorperazine, there is potential for dry mouth, dry eyes, urinary retention, constipation, and other anticholinergic effects.

Prochlorperazine does have the potential to have some alpha blocking activity. Keep an eye out for hypotension in patients who may be at risk.
13 min
September 26, 2019 Buspirone Pharmacology
Buspirone is an anti-anxiety medication that has the potential of having some serotonin agonist activity.
Buspirone has a very high first-pass metabolism. This means that the body breaks much of the medication down prior to it getting into the systemic circulation.
Buspirone is broken down by CYP3A4, so concomitant use with inhibitors or inducers can alter its concentrations
Buspirone should not be used as needed as this medication takes a while to start to show benefit.
Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

13 min
September 26, 2019 Buspirone Pharmacology
Buspirone is an anti-anxiety medication that has the potential of having some serotonin agonist activity.

Buspirone has a very high first-pass metabolism. This means that the body breaks much of the medication down prior to it getting into the systemic circulation.

Buspirone is broken down by CYP3A4, so concomitant use with inhibitors or inducers can alter its concentrations

Buspirone should not be used as needed as this medication takes a while to start to show benefit.
13 min
September 19, 2019 Ondansetron Pharmacology
Ondansetron (Zofran) is a medication used for nausea and vomiting. In this episode, I lay out the pharmacology, adverse effects, drug interactions and more!
Ondansetron has been reported to increase the risk of serotonin syndrome. I discuss this further on the podcast.
Ondansetron can exacerbate QTc prolongation. Keep an eye out for patients who may have risk factors or be on other medications that can contribute to this. I discuss this further on this podcast.
Ondansetron is often used for chemotherapy induced nausea and vomiting. I discuss this and other indications on the podcast.
Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

13 min
September 19, 2019 Ondansetron Pharmacology
Ondansetron (Zofran) is a medication used for nausea and vomiting. In this episode, I lay out the pharmacology, adverse effects, drug interactions and more!

Ondansetron has been reported to increase the risk of serotonin syndrome. I discuss this further on the podcast.

Ondansetron can exacerbate QTc prolongation. Keep an eye out for patients who may have risk factors or be on other medications that can contribute to this. I discuss this further on this podcast.

Ondansetron is often used for chemotherapy induced nausea and vomiting. I discuss this and other indications on the podcast.
13 min
September 12, 2019 Acyclovir Pharmacology
On this episode “Acyclovir Pharmacology” I discuss the mechanism of action, important monitoring parameters, and drug interactions with acyclovir.
I discuss why acyclovir has to be dosed so many times per day.
Acyclovir can inhibit CYP1A2 which can impact a few drugs. I discuss a couple of those examples on this podcast episode.
GI effects are one of the more common side effects of acyclovir.
Rarely, neuropathy and nephropathy can be part of the adverse effect profile of acyclovir. I discuss this further on this episode.
Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

18 min